Morphine depresses the transmission of noxious messages in the spino(trigemino)-ponto-amygdaloid pathway

Huang, Guo-Fen; Besson, Jean‐Marie; Bernard, Jean‐François

doi:10.1016/0014-2999(93)90562-v

Cited by 27 publications

(17 citation statements)

References 34 publications

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“…Recently, μ opioid and EP3 prostaglandin receptors were also found extensively in these “nociceptive” axodendritic system (Chamberlin et al, 1999; Engblom et al, 2000; Minami et al, 1994). Thus, the anti‐/pro‐nociceptive action of morphine and prostanoid inflammatory agents could be explained, at least in part, by a direct action upon the spino‐PB synaptic transmission (Huang et al, 1993; Matsumoto et al, 1996; Minami et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Dendritic domains of nociceptive‐responsive parabrachial neurons match terminal fields of lamina I neurons in the rat

Bourgeais

Gauriau

Monconduit

et al. 2003

J of Comparative Neurology

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This study investigates, in the anesthetized rat, the dendritic extent of parabrachial (PB) neurons whose nociceptive response to noxious stimuli has been previously recorded with an extracellular micropipette. The PB neurons were then injected with biocytin through the recording micropipette, via a juxtacellular technique. The dendritic arborization of individual PB neurons was carefully compared with the projections of medullary (trigeminal) and spinal lamina I neurons. The latter projections were labeled in separate animals that received injections of Phaseolus vulgaris-leucoagglutinin restricted to the superficial layers of spinal or medullary dorsal horn. We report here that: 1) PB neurons excited chiefly by noxious stimulation of the face have their dendritic tree located primarily within the field of lamina I trigeminal projections, i.e., in the caudal portion of PB area, around the external medial and the caudal part of the external lateral subnuclei; and 2) PB neurons excited chiefly by noxious stimulation of the paw or the tail have their dendritic tree located primarily within the field of lamina I spinal projections, i.e., in PB mid-extent, around the borderline between the external lateral and both the lateral crescent and the superior lateral subnuclei. Our results suggest the presence of an extensive excitatory axodendritic link between lamina I projections and PB nociceptive neurons around the lateral crescent and the external medial subnuclei. These findings strengthen the possibility of involvement of a subgroup of PB neurons in nociceptive processes.

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Section: Discussionmentioning

confidence: 99%

Dendritic domains of nociceptive‐responsive parabrachial neurons match terminal fields of lamina I neurons in the rat

Bourgeais

Gauriau

Monconduit

et al. 2003

J of Comparative Neurology

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“…The CeA is the major amygdaloid nucleus receiving nociceptive information, especially through the spinopontoamygdaloid pathway (Bernard and Besson, 1990;Bester et al, 2000). This ascending nociceptive pathway is inhibited by opioids (Huang et al, 1993b). Although ␦ and opioid receptors are also located in the CeA (Paden et al, 1987), their roles in opioid analgesia have not been studied previously.…”

Section: Downloaded Frommentioning

confidence: 99%

Effect of the μ Opioid on Excitatory and Inhibitory Synaptic Inputs to Periaqueductal Gray-Projecting Neurons in the Amygdala

Finnegan

Chen

Pan

2004

J Pharmacol Exp Ther

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Opioids are potent analgesics, but the sites of their action and cellular mechanisms are not fully understood. The central nucleus of the amygdala (CeA) is important for opioid analgesia through the projection to the periaquaductal gray (PAG). In this study, we examined the effects of opioid receptor stimulation on inhibitory and excitatory synaptic inputs to PAG-projecting CeA neurons retrogradely labeled with a fluorescent tracer injected into the ventrolateral PAG of rats. Whole-cell voltageclamp recordings were performed on labeled CeA neurons in brain slices. The specific opioid receptor agonist, [D-Ala 2 ,NMe-Phe 4 ,Gly 5 -ol]-enkephalin (DAMGO, 1 M), significantly reduced the frequency of miniature inhibitory postsynaptic currents (mIPSCs) without altering the amplitude and decay constant of mIPSCs in 47.6% (10 of 21) of cells tested. DAMGO also significantly decreased the peak amplitude of evoked IPSCs in 69% (9 of 13) of cells examined. However, DAMGO did not significantly alter the frequency of miniature excitatory postsynaptic currents (EPSCs) and the amplitude of evoked EPSCs in 69% (9 of 13) and 83% (10 of 12) of labeled cells, respectively. The IPSCs were blocked by the GABA A receptor antagonist bicuculline, whereas the EPSCs were largely abolished by the non-N-methyl-D-aspartate antagonist 6-cyano-7-nitroquinoxaline-2,3-dione. The immunoreactivity of opioid receptors was colocalized with synaptophysin, a presynaptic marker, in close appositions to labeled CeA neurons. These results suggest that activation of opioid receptors on presynaptic terminals primarily attenuates GABAergic synaptic inputs to PAG-projecting neurons in the CeA.

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“…Indeed, numerous nociceptive specific neurons projecting either to the amygdala or to the hypothalamus were recorded in and around this ''nociceptive'' PB region, the responses of which were depressed by i.v. morphine in a dose-dependent and naloxone-reversible manner Besson, 1988, 1990;Huang et al, 1993;Bernard et al, 1994;Bester et al, 1995b). Furthermore, noxious stimuli evoke the expression of c-Fos protein in a portion of this latter ''nociceptive'' PB area (Bellavance and Beitz, 1996;Hermanson and Blomqvist, 1996;Bester et al 1997b;Buritova et al 1998) that receives a dense projection from nociceptive neurons located in the superficial spinal laminae (Burton et al, 1979;Wiberg and Blomqvist, 1984;Cechetto et al, 1985;Hylden et al, 1985Hylden et al, , 1986aPanneton and Burton, 1985;Light et al, 1987;Bernard et al, 1989Bernard et al, , 1995bBlomqvist et al, 1989;Slugg and Light, 1994;Craig, 1995;Feil and Herbert, 1995;Bester et al, 1995a).…”

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confidence: 94%

Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: A PHA-L study in the rat

et al. 1999

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Morphine depresses the transmission of noxious messages in the spino(trigemino)-ponto-amygdaloid pathway

Cited by 27 publications

References 34 publications

Dendritic domains of nociceptive‐responsive parabrachial neurons match terminal fields of lamina I neurons in the rat

Dendritic domains of nociceptive‐responsive parabrachial neurons match terminal fields of lamina I neurons in the rat

Effect of the μ Opioid on Excitatory and Inhibitory Synaptic Inputs to Periaqueductal Gray-Projecting Neurons in the Amygdala

Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: A PHA-L study in the rat

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