Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats

Moon, Sohyeon; Kang, Sang Hun; Shin, Hee-yeon; Yayeh, Taddesse; Sur, Bongjun; Oh, Seikwan

doi:10.1007/s11064-019-02720-9

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Our lab has developed a unique three-day paradigm as a clinically relevant animal model to study the effects of multiple bouts of opioid withdrawal in mice [5][6][7] . This paradigm makes use of a moderate dose of a general opioid receptor agonist and common clinical analgesic, morphine, over a shorter duration than other paradigms 8,9 . Naloxone, a competitive opioid receptor antagonist, used clinically to reverse opioid overdose, is administered to quickly precipitate withdrawal.…”

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Examining opioid withdrawal scoring and adaptation of global scoring systems to male and female C57BL/6J mice

Bravo

Bluitt

McElligott

2021

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Opioid Use Disorder (OUD) is a chronic and relapsing psychiatric condition which is currently the leading cause of accidental death in the US. Symptoms of acute opioid withdrawal resemble a flu-like illness which is accompanied by a dysphoric state. Psychological comorbidities such as anxiety, depression, and disordered sleep can persist for months or years, well into the abstinence period. These symptoms are thought to drive further opioid intake in order to alleviate this unpleasant internal state. Many differences in OUD have been documented between male and female patients, with females at higher risk for relapse and overdose. This study sets out to characterize sex differences in symptoms and behavioral adaptations in mice during early withdrawal. Using our moderate dose, three day precipitated withdrawal paradigm, we discovered significant effects of sex, time, and drug treatment on early withdrawal behaviors, locomotor activity, and gut motility in C57BL/6J mice. Here I will discuss previous methods of condensing behavioral phenotypes into one global withdrawal score, and propose a new methodology. This method increases the ability to detect nuanced effects and allows for more accurate translation across strain, sex, paradigm, and experimental context. Classification of opioid withdrawal-induced behavioral adaptations will allow for improved behavioral analysis of pharmacological manipulations, and investigations of brain circuitry involved in opioid withdrawal, as well as future screening of compounds with potential therapeutic benefit for the treatment of OUD.

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confidence: 99%

Examining opioid withdrawal scoring and adaptation of global scoring systems to male and female C57BL/6J mice

Bravo

Bluitt

McElligott

2021

Preprint

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“…Estudos atuais demonstram que o TMCA pode ser considerado um potencial agente terapêutico reduzindo a dependência e tolerância à morfina, além de diminuir o número de saltos induzidos por naloxona, reduzir as pontuações na preferência de lugar condicionado e atenuar os padrões comportamentais associados ao uso prolongado de morfina em camundongos (Moon et al, 2019). Este estudo também revela a redução na expressão das proteínas fosforiladas na subunidade 1 do receptor de NMDA (pNR1), NR1 e na cinase regulada por sinal extracelular (pERK) no córtex frontal de camundongos, além de reduzir a expressão de 𝚫FosB no núcleo accumbens.…”

Section: Atividade Farmacológica Do Tmcaunclassified

Ácido 3,4,5-Trimetoxicinâmico e seu Potencial Terapêutico: Uma Revisão / 3,4,5-Trimethoxycinnamic Acid and Its Therapeutic Potential: A Review

Santos¹,

Gonzaga²,

Sousa³

et al. 2021

BJDV

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As plantas medicinais tem se constituído como uma das principais fontes na obtenção de novos fármacos e no desenvolvimento de medicamentos. A fitoterapia é praticada na Medicina Tradicional Chinesa há séculos e plantas como a Polygala tenuifolia Wild são amplamente usadas no tratamento da insônia, ansiedade, inquietação e desorientação. Um dos principais metabólitos ativos presentes em raízes desta planta é o ácido 3,4,5 trimetoxicinâmico (TMCA). Portanto, o objetivo do presente estudo foi buscar na literatura científica os principais métodos desenvolvidos para identificação e quantificação do TMCA em misturas, o perfil farmacocinético, a biodisponibilidade e as atividades farmacológicas do TMCA. Uma revisão sistemática foi realizada, na qual

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“…3,4,5-Trimethoxycinnamic acid (C 12 H 14 O 5 , TMCA; CAS 90-50-6; molar mass 238.24 g mol –1 ; Figure ) is one of the active components of traditional Chinese medicine Yuanzhi. − Previous literature reports have found that TMCA and its derivatives have important medical effects and are widely used in sleep disorders, depression, toxicity reduction, and other aspects, with good bioavailability. , Meanwhile, TMCA could generate antiseizure effects by combining with the GABAA (gamma-aminobutyric acid type A) receptor complex, which was utilized to exploit therapeutic agents for anxiety depression and therapeutic agents against morphine dependence . In addition, some derivatives synthesized with TMCA , showed good anticonvulsant activity and sedative effect, which was used for the development of anticonvulsant drugs and sedatives .…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Meanwhile, TMCA could generate antiseizure effects by combining with the GABAA (gamma-aminobutyric acid type A) receptor complex, 6 which was utilized to exploit therapeutic agents for anxiety depression 2 and therapeutic agents against morphine dependence. 7 In addition, some derivatives synthesized with TMCA 8,9 showed good anticonvulsant activity and sedative effect, which was used for the development of anticonvulsant drugs and sedatives. 10 In recent years, TMCA was also widely used as a representative bioactive component marker in the enrichment of sunscreen products.…”

mentioning

confidence: 99%

Measurement and Analysis of Solvent Behavior and Thermodynamic Properties of 3,4,5-Trimethoxycinnamic Acid in Industrial Common Solvents with Different Temperatures (T = 278.15–323.15 K)

et al. 2022

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Herein, the solubility and thermodynamic characterization solubility of 3,4,5-trimethoxycinnamic acid (TMCA) were studied by a static equilibrium method combined with high-performance liquid chromatography (HPLC), which provided a significant reference for crystallization and industrial separation of TMCA. First, the solubility data of TMCA was measured in 11 industrial common solvents and 4 binary mixed solvents at different temperatures (278.15–323.15 K) under atmospheric pressure. The results showed that the solubility of TMCA in the test solvents was positively correlated with temperature. In binary solvents, the increase in the mole fraction of the cosolvent also facilitated the dissolution of TMCA. Then, the monosolvent solubility data obtained in the experiment were fitted by the Buchowski–Ksiazaczak λh model and modified Apelblat model. The binary mixed solvent solubility data obtained in the experiment were fitted by the CNIBS/R–K model, Jouyban–Acree model, and SUN model. Meanwhile, the KAT-LSER model was also used to explore the effect of the solvation of TMCA. Furthermore, as can be seen from differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses, the purity of the sample is without crystal transformation before and after dissolution, indicating that the physical and chemical properties of the TMCA sample are stable in the experimental process, and the experimental data have good accuracy and reliability.

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Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats

Cited by 6 publications

References 29 publications

Examining opioid withdrawal scoring and adaptation of global scoring systems to male and female C57BL/6J mice

Examining opioid withdrawal scoring and adaptation of global scoring systems to male and female C57BL/6J mice

Ácido 3,4,5-Trimetoxicinâmico e seu Potencial Terapêutico: Uma Revisão / 3,4,5-Trimethoxycinnamic Acid and Its Therapeutic Potential: A Review

Measurement and Analysis of Solvent Behavior and Thermodynamic Properties of 3,4,5-Trimethoxycinnamic Acid in Industrial Common Solvents with Different Temperatures (T = 278.15–323.15 K)

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