Morning Serum Cortisol as a Predictor for the HPA Axis Recovery in Cushing’s Disease

Cui, Qiaoli; Liu, D.; Xiang, Boni; Sun, Quanya; Fan, Long; He, Min; Wang, Y.; Zhang, Xiaoming; Ye, H.

doi:10.1155/2021/4586229

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…HPA axis was evaluated with 8:00 a.m. cortisol level obtained before that day's glucocorticoid intake, followed by an ACTH stimulation test starting when the level was 2 ~ 10µg/dL (55 ~ 276 nmol/L). The recovery of HPA axis was de ned as 8:00 a.m. serum cortisol was more than 10µg/dL (276nmol/L) or stimulated level was approximately 18µg/dL (500 nmol/L) or greater 3,11 .…”

Section: Biochemical Remission Of CD Included Immediately Postoperati...mentioning

confidence: 99%

The recovery time of hypothalamic-pituitary-adrenal axis after curative surgery in Cushing’s disease and its predictor

Zhang

Cui

Liu

et al. 2022

Preprint

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Objective Patients with Cushing’s disease (CD) experienced transient central adrenal insufficiency (CAI) after successful surgery. However, the reported recovery time of hypothalamic-pituitary-adrenal (HPA) axis varied and the risk factors which could affect recovery time of HPA axis had not been extensively studied. This study aimed to analyze the duration of CAI and explore the risk factors affecting HPA axis recovery in post-operative CD patients with biochemical remission. Design and methods Medical records of diagnosis with CD in Huashan Hospital were reviewed between 2014 and 2020. 140 patients with biochemical remission and regular follow-up after surgery were enrolled in this retrospective cohort study according to the criteria. Demographic details, clinical and biochemical information at baseline and each follow-up (within 2 years) were collected and analyzed. Results Overall, 103 patients (73.6%) recovered from transient CAI within 2 years follow-up and the median recovery time was 12 months [95% confidence intervals (CI): 10–14]. The age and midnight ACTH at baseline were significantly lower, while the TT3 and FT3 levels were significantly higher in patients with recovered HPA compared to patients with CAI at 2-year follow-up(p < 0.05). In persistent CAI group, more patients underwent partial hypophysectomy. TT3 at diagnosis was an independent predictor of the recovery of HPA axis, even after adjusting for gender, age, duration, surgical history, maximum tumor diameter, surgical strategy, and postoperative nadir serum cortisol level (p = 0.04, OR: 6.03, 95% CI: 1.085, 22.508). Among patients with unrecovered HPA axis at 2-year follow-up, 23 CAI patients (62%) were accompanied by multiple pituitary axis dysfunction besides HPA axis, including hypothyroidism, hypogonadism, or central diabetes insipidus. Conclusion HPA axis recovered in 73.6% of CD patients within 2 years after successful surgery, and the median recovery time was 12 months. TT3 level at diagnosis was an independent predictor of postoperative recovery of HPA axis in CD patients. Moreover, patients coexisted with other hypopituitarism at 2-year follow-up had a high probability of unrecovered HPA axis.

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Section: Biochemical Remission Of CD Included Immediately Postoperati...mentioning

confidence: 99%

The recovery time of hypothalamic-pituitary-adrenal axis after curative surgery in Cushing’s disease and its predictor

Zhang

Cui

Liu

et al. 2022

Preprint

View full text Add to dashboard Cite

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The recovery time of hypothalamic-pituitary-adrenal axis after curative surgery in Cushing’s disease and its related factor

et al. 2023

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Is There a Relationship between Salivary Cortisol and Temporomandibular Disorder: A Systematic Review

AlSahman,

AlBagieh,

AlSahman

2024

Diagnostics

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Background: This systematic review examines and evaluates the relationship between salivary cortisol levels and temporomandibular disorder (TMD) in young adult patients. Method: Six databases—PubMed, Scopus, Web of Science, Google Scholar, ProQuest, and Cochrane Library—were utilized to screen eligible studies. A systematic search was performed based on PECO questions and eligibility criteria. The research question for this review was “Do salivary cortisol levels correlate with TMD in individuals aged 18–40?” The risk of bias for quality assessment was determined by the Cochrane tool. PRISMA guidelines were followed while performing this review. Result: A total of fourteen studies were included in this review. Of these, eleven were observational studies (four cross-sectional and seven case–control), and three were randomized control trials. Eleven of the included studies presented a low to moderate risk in the qualitative synthesis. The total sample size of the included studies was 751 participants. The included studies suggest higher salivary cortisol levels in TMD patients than in healthy individuals. Conclusions: The findings of this review indicate higher salivary cortisol levels in adult patients with TMD than in healthy controls. Thus, supportive psychological treatment and clinical modalities should be provided to patients with TMD. Moreover, higher-quality studies with low heterogeneity are required to support this finding.

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Morning Serum Cortisol as a Predictor for the HPA Axis Recovery in Cushing’s Disease

Cited by 3 publications

References 35 publications

The recovery time of hypothalamic-pituitary-adrenal axis after curative surgery in Cushing’s disease and its predictor

The recovery time of hypothalamic-pituitary-adrenal axis after curative surgery in Cushing’s disease and its predictor

The recovery time of hypothalamic-pituitary-adrenal axis after curative surgery in Cushing’s disease and its related factor

Is There a Relationship between Salivary Cortisol and Temporomandibular Disorder: A Systematic Review

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