Morning increase in the time of onset of sustained ventricular tachycardia

Twidale, Nicholas; Taylor, Susan; Heddle, Bill; Ayres, B.; Tonkin, Andrew

doi:10.1016/0002-9149(89)90881-3

Cited by 79 publications

(20 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was in keeping with the known morning increased incidence of ventricular tachycardia and sudden death in heart failure. 13 14 We note that our patients with CSR had poorer ventricular function, which may ordinarily be expected to lead to more arrhythmia. This obviously did not apply in our study because, by definition, all patients were already at a high risk of arrhythmia.…”

Section: Discussionmentioning

confidence: 84%

Collateral circulation in aortic coarctation shown by 64 channel multislice computed tomography angiography

Leschka¹

2005

Heart

View full text Add to dashboard Cite

Objective: To determine whether ventricular arrhythmia related to nocturnal hypoxaemia during CheyneStokes respiration (CSR) explains the observation that CSR is an independent marker of death in heart failure. Design: Prospective, observational study. Patients: 101 patients at high risk of clinical serious ventricular arrhythmia fitted with an implantable cardioverter-defibrillator (ICD). Measurements: Patients were studied at baseline for CSR during sleep. Arrhythmia requiring device discharge was used as a surrogate marker for possible sudden cardiac death. Results: 101 patients (42 with CSR) were followed up for a total of 620 months. Twenty six patients experienced 432 ICD discharge episodes. Twenty four (6%), 210 (49%), 125 (29%), and 73 (17%) episodes occurred across the time quartiles 0000-0559, 0600-1159, 1200-1759, and 1800-2359, respectively. Kaplan-Meier analysis showed a relative risk of 1 (95% confidence interval 0.5 to 2.2, p = 1) for device discharge in the CSR group. The average (SED) numbers of nocturnal ICD discharges per patient per month of follow up were 0.01 (0.01) and 0.04 (0.02) for patients with and without CSR, respectively (p = 0.6). Conclusion: These findings refute the proposition that CSR is related to heart failure death through nocturnal serious ventricular arrhythmia.

show abstract

Section: Discussionmentioning

confidence: 84%

Collateral circulation in aortic coarctation shown by 64 channel multislice computed tomography angiography

Leschka¹

2005

Heart

View full text Add to dashboard Cite

show abstract

“…For example, sudden cardiac death exhibits an increased frequency in the morning [45]. The majority of VT episodes in patients with dilated cardiomyopathy occurred during morning [46], with an increase in the onset of sustained VT at that time [47]. PVCs also increase in the morning [48], [49].…”

Section: Discussionmentioning

confidence: 99%

Morning Surge of Ventricular Arrhythmias in a New Arrhythmogenic Canine Model of Chronic Heart Failure Is Associated with Attenuation of Time-Of-Day Dependence of Heart Rate and Autonomic Adaptation, and Reduced Cardiac Chaos

et al. 2014

View full text Add to dashboard Cite

Patients with chronic heart failure (CHF) exhibit a morning surge in ventricular arrhythmias, but the underlying cause remains unknown. The aim of this study was to determine if heart rate dynamics, autonomic input (assessed by heart rate variability (HRV)) and nonlinear dynamics as well as their abnormal time-of-day-dependent oscillations in a newly developed arrhythmogenic canine heart failure model are associated with a morning surge in ventricular arrhythmias. CHF was induced in dogs by aortic insufficiency & aortic constriction, and assessed by echocardiography. Holter monitoring was performed to study time-of-day-dependent variation in ventricular arrhythmias (PVCs, VT), traditional HRV measures, and nonlinear dynamics (including detrended fluctuations analysis α1 and α2 (DFAα1 & DFAα2), correlation dimension (CD), and Shannon entropy (SE)) at baseline, as well as 240 days (240d) and 720 days (720d) following CHF induction. LV fractional shortening was decreased at both 240d and 720d. Both PVCs and VT increased with CHF duration and showed a morning rise (2.5-fold & 1.8-fold increase at 6 AM-noon vs midnight-6 AM) during CHF. The morning rise in HR at baseline was significantly attenuated by 52% with development of CHF (at both 240d & 720d). Morning rise in the ratio of low frequency to high frequency (LF/HF) HRV at baseline was markedly attenuated with CHF. DFAα1, DFAα2, CD and SE all decreased with CHF by 31, 17, 34 and 7%, respectively. Time-of-day-dependent variations in LF/HF, CD, DFA α1 and SE, observed at baseline, were lost during CHF. Thus in this new arrhythmogenic canine CHF model, attenuated morning HR rise, blunted autonomic oscillation, decreased cardiac chaos and complexity of heart rate, as well as aberrant time-of-day-dependent variations in many of these parameters were associated with a morning surge of ventricular arrhythmias.

show abstract

“…1), with the highest incidence occur ring between approximately 6 AM and noon (Cannon et al, 1997; Cohen et al, 1997; D’Avila et al, 1995; Elliott, 1998; Goldberg et al, 1990; Levine et al, 1992; Marler et al, 1989; Muller et al, 1985, 1987; Twidale et al, 1989; Willich et al, 1987, 1992). The above studies may under-report the occurrence of adverse cardiovascular events during nighttime due to people normally sleeping at this time.…”

Section: The Internal Clock and The Timing Of Adverse Cardiovascular mentioning

confidence: 99%

“…The above studies may under-report the occurrence of adverse cardiovascular events during nighttime due to people normally sleeping at this time. However, this possible reporting bias does not apply to the morning peak in arrhythmias because the precise timing of the events was recorded by electrocardiographic recordings (e.g., see Twidale et al, 1989). Furthermore, data obtained from implanted cardioverter-defibrillators—which also record the precise timing of the events—show that the defibrillation threshold (i.e., the amount of energy required) needed for successful defibrillation is greatest in the morning (Venditti et al, 1996).…”

Section: The Internal Clock and The Timing Of Adverse Cardiovascular mentioning

confidence: 99%

The impact of the circadian timing system on cardiovascular and metabolic function

Morris

Yang

Scheer

2012

Progress in Brain Research

165

101

View full text Add to dashboard Cite

Epidemiological studies show that adverse cardiovascular events peak in the morning (i.e., between 6 AM and noon) and that shift work is associated with cardiovascular disease, obesity, and diabetes. The endogenous circadian timing system modulates certain cardiovascular risk markers to be highest (e.g., cortisol, nonlinear dynamic heart rate control, and platelet activation) or to respond most unfavorably to stressors such as exercise (e.g., epinephrine, norepinephrine, and vagal cardiac modulation) at an internal body time corresponding to the time of day when adverse cardiovascular events most likely occur. This indicates that the circadian timing system and its interaction with external cardiovascular stressors (e.g., physical activity) could contribute to the morning peak in adverse cardiovascular events. Moreover, circadian misalignment and simulated night work have adverse effects on cardiovascular and metabolic function. This suggests that misalignment between the behavioral cycle and the circadian timing system in shift workers contributes to that population’s increased risk for cardiometabolic disease.

show abstract

Morning increase in the time of onset of sustained ventricular tachycardia

Cited by 79 publications

References 9 publications

Collateral circulation in aortic coarctation shown by 64 channel multislice computed tomography angiography

Collateral circulation in aortic coarctation shown by 64 channel multislice computed tomography angiography

Morning Surge of Ventricular Arrhythmias in a New Arrhythmogenic Canine Model of Chronic Heart Failure Is Associated with Attenuation of Time-Of-Day Dependence of Heart Rate and Autonomic Adaptation, and Reduced Cardiac Chaos

The impact of the circadian timing system on cardiovascular and metabolic function

Contact Info

Product

Resources

About