Morita.Baylis.Hillman Route to 8,9,9a,10-Tetrahydrobenzo[b][1,8]naphthyridine-6(7H)-ones and 3,4,4a,5-Tetrahydrodibenzo[b,g][1,8]naphthyridine-1(2H)-ones

Ahn, Soo Whan; Jang, Seung Soon; Kim, Yong Hyun; Lee, Kee‐Jung

doi:10.5012/bkcs.2011.32.8.3145

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…Due to their biological and synthetic importance, the development of effective routes to synthesize naphthyridines continues to be an active area of research for synthetic organic chemists [11]. A survey of the literature shows that the major synthetic approaches used to prepare the naphthyridine system involved condensation of 2-aminopyridine derivatives with carbonyl compounds containing an activated methylene group [12,13,14,15,16,17,18,19] or with β -ketoesters [20].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Synthesis of Novel Pyrazolo[3,4-g][1,8]naphthyridin-5-amine with Potential Antifungal and Antitumor Activity

et al. 2015

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Abstract:The microwave assisted reaction between heterocyclic o-aminonitriles 1 and cyclic ketones 2 catalyzed by zinc chloride led to new series of pyrazolo [3,4-b] [1,8]naphthyridin-5-amines 3 in good yields. This procedure provides several advantages such as being environmentally friendly, high yields, simple work-up procedure, broad scope of applicability and the protocol provides an alternative for the synthesis of pyrazolonaphthyridines. The whole series showed antifungal activities against Candida albicans and Cryptococcus neoformans standardized strains, being compounds with a 4-p-tolyl substituent of the naphthyridin scheleton (3a, 3d and 3g), the most active ones mainly against C. albicans, which appear to be related to their comparative hydrophobicity. Among them, 3d, containing a cyclohexyl fused ring, showed the best activity. The anti-Candida activity was corroborated by testing the three most active compounds against clinical isolates of albicans and non-albicans Candida strains. These compounds were also screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines. Compounds 3a and 3e showed remarkable OPEN ACCESSMolecules 2015, 20 8500 antitumor activity against cancer cell lines, with the most important GI50 values ranging from 0.62 to 2.18 μM.

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