Moringa oleifera leaves ethanolic extract influences DNA damage signaling pathways to protect liver tissue from cobalt -triggered apoptosis in rats

Khalil, Samah R.; Bohi, Khlood M. El; Khater, Safaa I.; El‐fattah, Amir H. Abd; Mahmoud, Fagr A.; Farag, Mayada R.

doi:10.1016/j.ecoenv.2020.110716

Cited by 17 publications

(3 citation statements)

References 59 publications

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“…For example, CoCl 2 -induced HIF1α expression correlated with apoptosis and may be related to the PI3K/Akt pathway [53]. Other researchers revealed that apoptosis associated with oxidative stress and DNA damage [54][55][56][57], may involve P53. Rana et al [58] found that P53 in breast cancer cells is HIF1α-dependent and overexpression of HIF1α-dependent BAX ultimately leads to apoptosis.…”

Section: Apoptosismentioning

confidence: 97%

The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro

Gao

et al. 2021

Front Biosci (Landmark Ed)

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Section: Apoptosismentioning

confidence: 97%

The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro

Gao

et al. 2021

Front Biosci (Landmark Ed)

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“…The leaves and fruits of 'Moringa Oleifera' are rich in calcium and phosphorus. Calcium and phosphorus are the main constituents of bones [4]. That means to keep the bones healthy and strong, the fruits and leaves of the 'Moringa Oleifera' tree can be eaten.…”

Section: Medicinal Properties Of Moringa Oleifera Leavesmentioning

confidence: 99%

Evaluation of Antioxidant Property of Moringa Oleifera Leaves and its Effectiveness Against Rheumatoid Arthritis

Kapil¹,

Deka

Lahkar

et al. 2021

JPRI

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The present study is performed with the purpose of evaluating the antioxidant nature of Moringa Oleifera leaves and the effectiveness of the leaf extract against the disease called Rheumatoid Arthritis. The disease is very chronic and it is a common disease. So the study is focused on the medicinal properties of Moringa Oleifera leaves, chemical composition of Moringa Oleifera leaves and seeds, the antioxidant nature of moringa leaves and its extracts, the effectiveness of moringa leaf extract against the Rheumatoid Arthritis disease, reason behind the effectiveness of moringa leaves and discussion and analysis of the result generated.

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“…In addition, it has been reported that the cobalt (II)-chloride (CoCL 2 ) component causes a decrease in antioxidants and an increase in nuclear factor kappa-B (NF-κB), a proinflammatory cytokine, in heart and kidney tissues ( Oyagbemi et al, 2020 ). Co can also induce oxidative damage in the liver by increasing oxidant production and decreasing the antioxidant capacity ( Khalil et al, 2020 ). The cause of this Co-related toxicity is thought to be its bioaccumulation in the heart, kidney, liver, and pancreas ( Harbak, and Bennekou, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of cinnamon extract against cobalt-induced multiple organ damage in rats

Isik,

Suleyman,

Mammadov

et al. 2024

Front. Pharmacol.

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BackgroundThe role of oxidative stress and inflammation in cobalt (Co) toxicity has been the focus of previous studies. Cinnamon and its main components have been reported to have protective effects in various tissues with antioxidant and anti-inflammatory effects.AimsIn this study, the protective effect of cinnamon extract (CE) against possible Co-induced heart, kidney, and liver damage in rats was investigated biochemically.MethodsEighteen albino Wistar-type male rats were categorized into three groups (n = 6 per group): control (CG), CoCL2-administered (CoCL2), and CE + CoCL2-administered (CE + Co) groups. The CE + CoCL2 group was administered CE (100 mg/kg), and the CoCL2 and CG groups were administered distilled water orally by gavage. One hour after the administration, Co (150 mg/kg) was administered orally to the CE + CoCL2 and CoCL2 groups. This procedure was repeated once daily for 7 days. Then, biochemical markers were studied in the excised heart, kidney, and liver tissues.ResultsCoCL2 increased oxidants and proinflammatory cytokines and decreased antioxidants in heart, kidney, and liver tissues. Heart, kidney, and liver tissue were affected by Co damage. CE treatment suppressed the CoCL2-induced increase in oxidants and proinflammatory cytokines and decrease in antioxidants in heart, kidney, and liver tissues. CE treatment has been shown to attenuate cardiac damage by reducing serum troponin I (TpI) and creatine kinase-MB (CK-MB), renal damage by reducing creatinine and blood urea nitrogen (BUN), and liver damage by reducing alanine aminotransferase (ALT) and aspartate aminotransferase (AST).ConclusionCo induced the production of oxidants and proinflammatory parameters and antioxidant depletion in heart, kidney, and liver tissues of rats. Our experimental results show that CE protects heart, kidney, and liver tissues against oxidative and inflammatory changes induced by CoCLl2.

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Moringa oleifera leaves ethanolic extract influences DNA damage signaling pathways to protect liver tissue from cobalt -triggered apoptosis in rats

Cited by 17 publications

References 59 publications

The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro

The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro

Evaluation of Antioxidant Property of Moringa Oleifera Leaves and its Effectiveness Against Rheumatoid Arthritis

Protective effect of cinnamon extract against cobalt-induced multiple organ damage in rats

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