Moringa oleifera leaf powder alters the pharmacokinetics of amodiaquine in healthy human volunteers

Olawoye, Olanrewaju Samuel; Adeagbo, Babatunde Ayodeji; Bolaji, Oluseye O.

doi:10.1111/jcpt.12725

Cited by 15 publications

(14 citation statements)

References 26 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, it has been shown that a pharmacokinetic interaction exists between the antimalarial drug amodiaquine and Moringa oleifera Lam., a commonly used medicinal plant with multiple health benefits, when given together or following a long period of ingestion of Moringa oleifera Lam. In the presence of Moringa oleifera Lam., the peak plasma concentration of amodiaquine decreased by up to 40%, as well as its area under the plasma concentration-time curve which decreased by approximately 11%, leading to a significantly delayed absorption of amodiaquine (Olawoye et al, 2018). Overall, establishing herbal toxicity can be difficult.…”

Section: Challenges Associated With the Herbal Medicine Practicementioning

confidence: 99%

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

Hajj

Holst

2020

Front. Pharmacol.

View full text Add to dashboard Cite

Herbal medicine use has grown considerably worldwide among pregnant women, and is particularly widespread in sub-Saharan Africa. However, herbal medicines used across sub-Saharan Africa are associated with important research gaps and a lack of regulatory framework. This is particularly problematic, as herbal medicine use during pregnancy raises several concerns attributed to the herbal ingredient itself, conventional drug-herbal medicine interactions, and contamination or adulteration of herbal remedies. Moreover, several local herbal remedies used by sub-Saharan African pregnant women have never been botanically identified. In this review, an overview of the practice of herbal medicine, including the regulations, challenges and overall safety, is provided. Then, we discuss the prevalence of herbal medicine use during pregnancy across different sub-Saharan African countries, as well as the indications, adverse outcomes, and effectiveness of the most commonly used herbal medicines during pregnancy in that region.

show abstract

Section: Challenges Associated With the Herbal Medicine Practicementioning

confidence: 99%

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

Hajj

Holst

2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…The crude preparation of the plant leaves in aqueous form also demonstrated antimalarial activities by suppressing P. berghei ANKA infection in mice (137). Very recently, Olawoye et al (138) studied the actions of M. oleifera powdered leaves on amodiaquine (AQ) pharmacokinetics in healthy twenty human volunteers and established a positive interaction between AQ and M. oleifera suggesting a possible combinatorial therapy for malaria. The methanolic seed extract of M. oleifera also exhibited significant insecticidal activities, which could be exploited for integrated pest management to control the Anopheles mosquito (139).…”

Section: Anti-malaria Activitiesmentioning

confidence: 99%

A systematic review of pharmacological activities and safety ofMoringa oleifera

Popoola
¹
,

Aworunse
²
,

Oyesola
³

et al. 2020

J Herbmed Pharmacol

10
2
3
0

View full text Add to dashboard Cite

In the last few decades, Moringa oleifera, a multipurpose medicinal plant (MMP) has received increased research attention and commercial interest for its nutritional, therapeutic and pharmacological properties. Rigorous approaches including biological assays, animal and clinical trials are required towards safe usage as herbal therapy. We conducted a systematic review of the known pharmacological activities, toxicity, and safety of M. oleifera, usually used locally in the treatment and prevention of myriads of illnesses. Five major bibliographic databases (SCOPUS, Web of Science, Science Direct, PubMed, and Mendeley) were searched for studies reported on pharmacological activities, toxicity, and safety assessment of M. oleifera in the last 29 years (1990 – 2019). Studies on animals and humans involving aqueous leaf extracts and different preparations from M. oleifera seed and bark were also considered. All articles retained, and data collected were evaluated based on the period of the article, country where such studies were conducted and the document type. Our search results identified and analyzed 165 articles while 63 studies were eventually retained. Diverse pharmacological activities including neuroprotective, antimicrobial, antiasthmatic, anti-malaria, cardioprotective, antidiabetic, antiobesity, hepatoprotective and cytotoxic effects, amongst others, were recorded. Toxicity studies in animal models and few human studies showed that M. oleifera is safe with no adverse effect reported. The importance of the plant is highlighted in the search for new bioactive compounds to explore its therapeutic potentials towards drug discovery and development in the pharmaceutical and allied industries.

show abstract

“…This recommendation is especially useful when considering the use of moringa leaves as an ingredient in fortifying foods of infants whose bodies are at crucial stages of development. A study by Olawoye et al (2018) also revealed that there was a pharmacokinetic interaction between amodiaquine, a popular drug for the treatment of malaria, and MLP when given together or following a long period of ingestion of MLP (Olawoye et al, 2018). This finding is particularly important, as it indicates that the presence of MLP may alter the amount of amodiaquine absorbed, thus resulting in either subtherapeutic or toxic serum levels (Olawoye et al, 2018).…”

Section: The Way Forwardmentioning
confidence: 99%

“…A study by Olawoye et al (2018) also revealed that there was a pharmacokinetic interaction between amodiaquine, a popular drug for the treatment of malaria, and MLP when given together or following a long period of ingestion of MLP (Olawoye et al, 2018). This finding is particularly important, as it indicates that the presence of MLP may alter the amount of amodiaquine absorbed, thus resulting in either subtherapeutic or toxic serum levels (Olawoye et al, 2018). Given that MLP is being considered for use in infant and young child populations in low-resource settings where malaria is likely to be endemic, there is a high possibility of simultaneous administration of MLP with anti-malarials with little known ramifications, if infants NFS 49,3 are fed with complementary foods fortified with MLP.…”

Section: The Way Forwardmentioning
confidence: 99%

Sensory attributes and acceptability of complementary foods fortified with Moringa oleifera leaf powder
Boateng
¹
,
Nortey
²
,
Ohemeng
³

et al. 2019
NFS
26
3
23
0
View full text Add to dashboard Cite

Purpose Inadequacies in several micronutrients in complementary foods, notably iron, zinc, calcium, vitamin A, vitamin B6 and riboflavin have been reported. Moringa oleifera leaf powder (MLP), prepared from dried moringa leaves is nutrient-rich and has been explored for the treatment of micronutrient deficiencies among children in developing countries. This increasing interest in the use of moringa oleifera leaves to improve complementary foods notwithstanding, the unique sensory characteristics of the leaf powder potentially holds implications for the acceptability of local diets that are fortified with it. The purpose of this paper is to investigate the levels of MLP fortification that are most acceptable for feeding infants and young children. Design/methodology/approach The authors performed a review of the literature, with the aim of investigating the sensory attributes and acceptable levels of fortification of complementary food blends fortified with different levels of MLP. Findings The minimum amount of MLP to be added to a complementary food blend to observe significant improvements in its nutritional value was estimated to be about 10 per cent. However, at this 10 per cent fortification level also, sensory attributes of the products begin to become less desirable. Practical implications For the success of nutrition interventions that involve the use of MLP to improve the nutritional quality of complementary foods, there is a need to consider the acceptability of the sensory attributes of the formulated blends in the target group. Safety of MLP as an ingredient in infant foods must also be investigated. Originality/value The authors of this paper make recommendations for the use of MLP to fortify complementary foods to ensure its success as a food fortificant in nutrition interventions. The researchers are not aware of any published study that focuses on this subject.

show abstract

Moringa oleifera leaf powder alters the pharmacokinetics of amodiaquine in healthy human volunteers

Abstract: The study established pharmacokinetic interaction between AQ and MO when given together or following a long period of ingestion of MO. This may have clinical implications for malaria therapy.

Cited by 15 publications

References 26 publications

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

A systematic review of pharmacological activities and safety ofMoringa oleifera

Sensory attributes and acceptability of complementary foods fortified with Moringa oleifera leaf powder

Contact Info

Product

Resources

About