Moringa oleifera leaf extract induces osteogenic-like differentiation of human osteosarcoma SaOS2 cells

Khan, Mohammad Idreesh; Siddiqui, Sahabjada; Barkat, Md. Abul; Alhodieb, Fahad Saad; Ashfaq, Fauzia; Barkat, Harshita Abul; Alanezi, Abdulkareem A.; Arshad, Md

doi:10.1016/j.jtcme.2022.08.006

Cited by 6 publications

(2 citation statements)

References 45 publications

(52 reference statements)

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“…Such adverse effects significantly detract from the success rates of these treatments, underscoring an urgent need for alternative therapeutic strategies that can ameliorate these complications and offer hope to those afflicted by osteosarcoma or osteoporosis. [2] Natural treatment is always welcomed, basing on this concept, we selected hispidin for this study. This compound is a yellow phenolic compound, synthesized by different species of Inonotus and Phellinus Genera (Hymenochaetaceae family).…”

Section: Introductionmentioning

confidence: 99%

“…The conventional treatment modalities for osteosarcoma, namely chemotherapy and radiotherapy are fraught with a plethora of side effects including nausea, vomiting, diarrhea, dermatitis, electrolyte imbalances, and severe skin reactions. Such adverse effects significantly detract from the success rates of these treatments, underscoring an urgent need for alternative therapeutic strategies that can ameliorate these complications and offer hope to those afflicted by osteosarcoma or osteoporosis [2] …”

Section: Introductionmentioning

confidence: 99%

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Exploring the Anti‐Cancer Potential of Hispidin: A Comprehensive in Silico and in Vitro Study on Human Osteosarcoma Saos2 Cells

Benarous,

Serseg,

Mermer

et al. 2024

Chemistry & Biodiversity

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Hispidin was initially discovered in basidiomycete Inonotus hispidus (Bull.) P. Karst and this extraordinary compound possesses immense potency and can be extracted from the wild mushroom through specialized bioreactor cultivation techniques. In our study, we isolated it from Inonotus hispidus (Bull.) P. Karst., with a yield of 3.6%. We identified and characterized hispidin through the implementation of spectroscopic techniques such as FTIR, NMR, and MS. Additionally, we utilized Thermogravimetric Analysis for thermal characterization of the compound. Computational studies based on DFT were performed to investigate the molecular structure, electronic properties, and chemical reactivity of hispidin. PASS analysis for hispidin demonstrated that 19 of them are anti‐neoplastic activities. The Pharmacology prediction of hispidin confirm that it is not toxic, non‐carcinogenesis with a good human intestinal absorption. The effect of hispidin on the viability of bone cancer cells was evaluated by MTT assay. The results showed that hispidin significantly reduced SaoS2 cell viability in a dose‐dependent manner. Molecular docking was carried out using five targets related to bone cancer to determine the interactions between hispidin and the studied proteins. The results demonstrate that hispidin is a good inhibitor for the five targets. Dynamic simulation shows a good stability of the complex hispidin‐protein.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Anti‐Cancer Potential of Hispidin: A Comprehensive in Silico and in Vitro Study on Human Osteosarcoma Saos2 Cells

Benarous,

Serseg,

Mermer

et al. 2024

Chemistry & Biodiversity

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Environmental, industrial, and health benefits of Moringa oleifera

Mahaveerchand,

Abdul Salam

2024

Phytochem Rev

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The rise of air, water, and soil pollution poses a significant threat to global health, leading to widespread disease and premature mortality. Soil health is vital, ensuring the production of safe food, but it is compromised by pollutants such as heavy metals, pesticides, plastics, and excessive fertilization, resulting in the depletion of beneficial microorganisms and subsequently groundwater contamination. Water bodies are polluted due to contamination from industrial effluents, domestic wastewater, agricultural runoff, and oil spillage, further intensifying environmental pollution. On the other hand, atmospheric pollution, characterized by high emissions of gases, volatile compounds, greenhouse gases, not only impacts the climate but also poses serious risks to human health, leading to respiratory diseases, cardiovascular issues, and increased cancer risks. Thus, the strategic utilization of traditional plants emerges as a potent tool for environmental restoration and improving human health. The plants possess natural filtering capabilities, absorbing pollutants from air, soil, and water, thus mitigating their adverse effects. Through phytoremediation, plants can be actively used to extract and remove contaminants, contributing to detoxification and improving water and soil quality. Additionally, plants offer various health benefits. Moringa oleifera or the drumstick plant belonging to the Moringaceae family is one such indigenous plant with wide applications, that can be grown in extreme arid conditions. Since ancient times, this plant has been used for treating skin infections, anaemia, and blood impurities. This plant thrives in diverse climates addressing over 300 different aliments. Rich in phytochemicals and bioactive compounds, M. oleifera serve as a superfood, offering high nutritional values and exhibiting potential for drug development with fewer side effects. Extensive research has elucidated the diverse properties and applications of M. oleifera, however, in-depth research is needed to identify bioactive molecules, phytochemicals, and protein compounds involved, which will aid in understanding of the mechanisms of action of the plant's diverse functions. Although studies have reported several of individual M. oleifera attributes, there is no comprehensive study available addressing its diverse applications. This review covers the findings of past three decades and provides a detailed outline of M. oleifera plant and its various parts, its applications in environmental, industrial, food and health aspects documented to date.

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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review

Tayeb,

Kusuma,

Osman

et al. 2024

Journal of Integrative Medicine

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Moringa oleifera leaf extract induces osteogenic-like differentiation of human osteosarcoma SaOS2 cells

Cited by 6 publications

References 45 publications

Exploring the Anti‐Cancer Potential of Hispidin: A Comprehensive in Silico and in Vitro Study on Human Osteosarcoma Saos2 Cells

Exploring the Anti‐Cancer Potential of Hispidin: A Comprehensive in Silico and in Vitro Study on Human Osteosarcoma Saos2 Cells

Environmental, industrial, and health benefits of Moringa oleifera

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review

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