Moringa oleifera, a species with potential analgesic and anti-inflammatory activities

Martínez-González, Claudia Lizbeth; Martı́nez, Luis M.; Martínez-Ortiz, Efraín; González-Trujano, María Eva; Déciga-Campos, Myrna; Ventura-Martı́nez, Rosa; Díaz-Reval, Irene

doi:10.1016/j.biopha.2016.12.107

Cited by 50 publications

(33 citation statements)

References 26 publications

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“…Our data on extracts E1 and E2, obtained by hexane and diethylether, show that beside moringin, other non-polar or low-polar compounds can contribute to the activity on TRPA1; this data is in agreement with the previously reported identification of analgesic effects also in non-polar extracts [24].…”

Section: Discussionsupporting

confidence: 93%

“…The use of moringa and its extracts for medicinal purposes is well established; in particular, recent evidences for its analgesic activity has been reported. Pharmacological evaluation of non-polar and/or polar extracts was explored through several experimental nociception models as formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats [24]. The authors found that both polar and non-polar extracts produced significant inhibition of nociceptive behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Potential analgesic activities, in vivo anti-arthritic and evidences of broad spectrum of anti-nociceptor effects were described in the literature. [24,25].…”

Section: Moringa Oleifera Lam a Multi-purpose Treementioning

confidence: 99%

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Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Borgonovo

Petrocellis²,

Moriello³

et al. 2020

Molecules

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Moringa oleifera Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate (moringin) has been widely studied for its bioactivity as hypoglycemic, antimicrobial, anticancer and in particular for its involvement in nociception and neurogenic pain. Moringa extracts and pure moringin were submitted to in vitro assays with the somatosensory TRPA1 ion channel, proving that moringin is a potent and effective agonist of this receptor involved in nociceptive function and pain states. Moringin do not activate or activates very weakly the vanilloids somatosensory channels TRPV1,2,3 and 4, and the melastatin cooling receptor TRPM8. The comparison of moringin’s activity with other known agonists of natural origin is also discussed.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Borgonovo

Petrocellis²,

Moriello³

et al. 2020

Molecules

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“…Both polar and non-polar extracts of M. oleifera leaves were effective in both phases of formalin test. Due to the presence of central and peripheral actions of non-polar active compounds, the hexane extract was more effective than the ethanolic extract (29).…”

Section: Discussionmentioning

confidence: 95%

Antinociceptive Action of Moringa peregrina is Mediated by Interaction with α2-Adrenergic Receptor

et al. 2020

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Background: Moringa peregrina (M. peregrina) is an edible, drought-resistant tree that is native to semi-arid countries. It is used as a painkiller in folk medicine. Aims: To study the antinociceptive effects of the leaf extract of M. peregrina in mice. Study Design: Animal experimentation. Methods: We employed thermal (hot plate and tail-immersion tests) and chemical (writhing and formalin tests) pain models in male BALB/c mice (eight animals per group) to investigate the mechanisms involved in the antinociceptive actions of M. peregrina. Additionally, we identified the chemical constituents present in the extract of M. peregrina by using liquid chromatography-mass spectrometry analysis, and predicted the possible active constituents that interact with the receptor based on molecular docking simulations. Results: In the writhing test, 200 mg/kg of M. peregrina extract restricted abdominal cramps by up to 55.97% (p<0.001). Further, it reduced the time of paw-licking in the early and late phases of formalin test by up to 56.8% and 65.5%, respectively, as compared to the percentage inhibitions of 50.5% and 48.4% produced by 30 mg/kg diclofenac sodium in the early and late phases, respectively (p<0.05). This effect was abrogated by yohimbine (1 mg/kg, intraperitoneally), but not by methysergide (5 mg/kg, intraperitoneally), in the late phase only, which indicates that the action of M. peregrina in formalin test is not mediated by 5-HT2 serotonin receptors, but rather via α 2adrenergic receptors. In the hot plate test, but not on tail-immersion test, the high dose (400 mg/kg) of the extract increased the latency time after 30 minutes of its administration. Yohimbine antagonized the action of M. peregrina in the hot plate test. Based on LC-MS analysis, the major constituents found in M. peregrina methanolic extract were chrysoeriol 7-O-diglucoside, lupeol acetate, quercetin, and rutin. Depending on the molecular docking results, the activity of M. peregrina extract could be due to the binding of chrysoeriol 7-O-diglucoside, quercetin, and rutin to the α 2-adrenergic receptor. Conclusion: Interaction with the α 2-adrenergic receptor serves as a possible mechanism of the M. peregrina analgesic effect.

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“…M. oleifera is commonly known as Drumstick and contains many active compounds such as alkaloids, flavonoids, saponins, tannins, and triterpenoids [7]. Extracts from this plant have several pharmacological effects such as anthelminthic [8-10], anti-inflammatory, antimicrobial, and antioxidant [11]. …”

Section: Introductionmentioning

confidence: 99%

Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

Hegazı¹,

Megeed²,

Hassan³

et al. 2018

Vet World

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Background:Fasciolosis is an important zoonotic disease affecting the productive performance of farm animals in Egypt.Aim:The aim of the present study was comparing the ovicidal effect of different extracts as an alcoholic (Methanolic and Ethanolic) and aqueous Moringa oleifera leaf extracts on Fasciola gigantica non-embryonated and developed eggs.Materials and Methods:Tested concentrations of extracts ranged from 12.5 to 800 mg/ml. Nitroxynil was used as reference drug with a dose of 100 mg/ml.Results:M. oleifera alcoholic and aqueous extracts showed a concentration-dependent ovicidal effect on F. gigantica non-embryonated and developed eggs. Based on LC50 values, water extract showed the highest ovicidal activity since it registered the lowest values of 2.6 mg/ml on non-embryonated eggs. Non-embryonated eggs were more susceptible to aqueous extract than developed eggs. On the other hand, the developed eggs were more susceptible to ethanolic extract than non-embryonated eggs even the lowest LC50 (12.38 mg/ml).Conclusion:M. oleifera leaf extracts especially aqueous extract could be a promising step in the field of controlling fascioliasis. Further, in vivo studies are needed to enlighten the therapeutic potential of M. oleifera extracts in treating F. gigantica infection.

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Moringa oleifera, a species with potential analgesic and anti-inflammatory activities

Cited by 50 publications

References 26 publications

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Antinociceptive Action of Moringa peregrina is Mediated by Interaction with α2-Adrenergic Receptor

Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

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