Moringa gum and its modified form as a potential green polymer used in biomedical field

Badwaik, Hemant Ramachandra; Hoque, Ashique Al; Kumari, Leena; Sakure, Kalyani; Baghel, Madhuri; Giri, Tapan Kumar

doi:10.1016/j.carbpol.2020.116893

Cited by 31 publications

(6 citation statements)

References 51 publications

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“…[12] Having protein content of about 6.7 % and 19-30 %, respectively for the fresh and dry leaves, [15] as well as 17 amino acids, of which eight are essential and eleven are non-essential, M. oleifera leaves has thus been considered a reputable source of high quality plant proteins. [16,17] The huge diversity and abundance of bioactive and nutrient composition of M. oleifera leaves is responsible for the reported health benefits and associated nutritional appeal.…”

Section: Introductionmentioning

confidence: 99%

“…Although the specific nutrient composition of M. oleifera leaves may vary depending on the geographical location where the plant was cultivated, soil type, climatic conditions, as well as harvesting period, what is consistent is the fact that irrespective of the afore‐mentioned influences, the leaves are often low in fats but highly abundant in proteins, carbohydrates and vitamins [12] . Having protein content of about 6.7 % and 19–30 %, respectively for the fresh and dry leaves, [15] as well as 17 amino acids, of which eight are essential and eleven are non‐essential, M. oleifera leaves has thus been considered a reputable source of high quality plant proteins [16,17] . The huge diversity and abundance of bioactive and nutrient composition of M. oleifera leaves is responsible for the reported health benefits and associated nutritional appeal.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Fermentation on the Phytochemical Content and Biological Properties of Moringa oleifera Lam. Shoot Teas

Ezekiel Adekoya,

Chika Eze,

Ezechukwu Okpara

et al. 2024

Chemistry & Biodiversity

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This work examined the variation in chemical and biological properties of Moringa oleifera Lam. shoot (MOS) teas prepared under different degrees of fermentation, viz: non‐fermented, semi‐fermented and fermented. The chemical composition was ascertained via FTIR, GC‐MS, total phenolic and total flavonoid content. Also determined were the biological properties, including antioxidant, antimicrobial and alpha‐amylase inhibitory activities. The data confirmed that MOS teas were rich in phenolic and flavonoid compounds, with fermented MOS tea displaying the highest phenolic and flavonoid contents. With respect to antioxidant property, all tea extracts exhibited good radical scavenging activities against DPPH˙, ABTS˙+ and NO˙, and the radical scavenging capacity was in the order of non‐fermented > semi‐fermented > fermented MOS teas. The same trend was also observed for the antimicrobial activities against Staphylococcus aureus and Staphylococcus epidermidis. In contrast, the fermented MOS tea exhibited better α‐amylase inhibitory activity compared to the non‐fermented and semi‐fermented MOS teas.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Fermentation on the Phytochemical Content and Biological Properties of Moringa oleifera Lam. Shoot Teas

Ezekiel Adekoya,

Chika Eze,

Ezechukwu Okpara

et al. 2024

Chemistry & Biodiversity

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“…An exudate from the bark of Moringa oleifera Lam. (family: Moringaceae) tree, called moringa exudate gum (MEG), contains huge amounts of polysaccharide [23,24]. Acid hydrolysis of MEG produces residues like L-galactose, L-arabinose, L-rhamnose and Lgluconic acid.…”

Section: Introductionmentioning

confidence: 99%

“…Acid hydrolysis of MEG produces residues like L-galactose, L-arabinose, L-rhamnose and Lgluconic acid. MEG has been used as a disintegrant, binding agent, and drug release retardant in several pharmaceutical formulations [23]. MEG possesses a lot of medicinal applications in the treatment of dysentery, intestinal cancer, and asthma [25,26].…”

Section: Introductionmentioning

confidence: 99%

Thiolated Moringa Exudate Gum as Improved Bio-Mucoadhesive Agent in the Formulations of Dental Paste and Gel

Bandyopadhyay

Nayak

2023

Int J App Pharm

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Objective: The objectives of the current study were to synthesize thiolated moringa exudate gum (TMEG) via thiolation of moringa exudate gum (MEG) and to evaluate TMEG as an improved bio-mucoadhesive agent in semi-solid formulations like dental paste and gel. MEG-and TMEG-based mucoadhesive dental pastes of aceclofenac and mucoadhesive gels of metronidazole were prepared and changes in bio-mucoadhesion capability were studied. Methods: In the current study, extracted MEG was modified to synthesize TMEG via thiolation (by utilizing thioglycolic acid in an acidic milieu) to study improvement in bio-mucoadhesive capability. MEG-and TMEG-based mucoadhesive dental pastes of 1% w/w aceclofenac and mucoadhesive gels of 1% w/w metronidazole were prepared with MEG and TMEG (as mucoadhesive excipient) in order to evaluate a comparative view of improvement in bio-mucoadhesion. Results: The yield percentage of TMEG was found to be 44.62% and the thiol group in TMEG was found 4.17 mmol of thiol group/g of MEG. FTIR analysis results indicated the thiolation of MEG in the synthesized TMEG. Both types of semi-solid formulations (mucoadhesive dental pastes of 1% w/w aceclofenac and mucoadhesive gels of 1% w/w metronidazole) prepared using TMEG as mucoadhesive excipient exhibited excellent improved ex vivo bio-mucoadhesion and a sustained pattern of drug-releasing over a prolonged period. Conclusion: The synthesized TMEG can be used as an improved mucoadhesive agent in the designing of bio-mucoadhesive semi-solid formulations for prolonged drug delivery.

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“…It is most typically used to improve the water solubility, viscosity, swellability, and bioactivity of polysaccharides. It provides structural diversity and a degree of crystallinity, enhances surface irregularity, imparts an anionic property, and even adds new bioactivities [ 26 , 27 ]. The low cost of chemical reagents, ease of processing, and nontoxicity of the products are the key advantages of this reaction [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

Baghel¹,

Sakure²,

Giri

et al. 2023

Pharmaceuticals

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Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured synthetics because of their intrinsic physicochemical characteristics. Studies showed that the carboxymethylation of polysaccharides considerably increases the aqueous solubility and bioactivities of inherent polysaccharides and offers structural diversity, but it also has some limitations that can be resolved by derivatization or the grafting of carboxymethylated gums. The swelling ratio, flocculation capacity, viscosity, partition coefficient, metal absorption properties, and thermosensitivity of natural polysaccharides have been improved as a result of these changes. In order to create better and functionally enhanced polysaccharides, researchers have modified the structures and properties of carboxymethylated gums. This review summarizes the various ways of modifying carboxymethylated gums, explores the impact that molecular modifications have on their physicochemical characteristics and bioactivities, and sheds light on various applications for the derivatives of carboxymethylated polysaccharides.

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Moringa gum and its modified form as a potential green polymer used in biomedical field

Cited by 31 publications

References 51 publications

Impact of Fermentation on the Phytochemical Content and Biological Properties of Moringa oleifera Lam. Shoot Teas

Impact of Fermentation on the Phytochemical Content and Biological Properties of Moringa oleifera Lam. Shoot Teas

Thiolated Moringa Exudate Gum as Improved Bio-Mucoadhesive Agent in the Formulations of Dental Paste and Gel

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

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