Morin exhibits leukemic cellular apoptosis through caspase pathway

Pereira, Willian; Oliveira, Tânia Toledo de; Kanashiro, Milton; Filardi, Marcelo Augusto; Costa, Marcelo Rocha da; Costa, Liovando Marciano da

doi:10.1080/14786419.2020.1795656

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Previously, morin has been studied for its antioxidant, anti-inflammatory, and antidiabetic properties, as well as its activity to induce apoptosis in U937 cells [ 27 , 28 ] and arrest cell cycle and induce apoptosis in HL-60 cells [ 29 ]. Resveratrol, on the other hand, has been shown to have various pharmacological effects, including antioxidant, anti-aging, anti-obesity, anti-diabetes, cardioprotection, and neuroprotection properties [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Biological activities of extracts and compounds from Thai Kae-Lae (Maclura cochinchinensis (Lour.) Corner)

Rueankham

Panyajai

Saiai

et al. 2023

BMC Complement Med Ther

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Background and aims The purpose of this study was to investigate the biological properties of Kae-Lae (Maclura cochinchinensis (Lour.) Corner), a traditional medicinal plant used in Ayurvedic recipes in Thailand. To achieve this objective, heartwood samples were collected from 12 sources across Thailand. Fractional extracts (n-hexane, ethyl acetate, and ethanol) and the dominant compounds (morin, resveratrol, and quercetin) were examined for their abilities on cytotoxicity, antioxidant, anti-inflammation, and antileukaemic activity (Wilms’ tumour 1 protein was used as a well-known biomarker for leukaemic cell proliferation). Methods The study used MTT to assess cytotoxicity in leukaemic cells (K562, EoL-1, and KG-1a). Antioxidant activities were evaluated using ABTS, DPPH, and FRAP assays. The anti-inflammatory activity was investigated by detecting IL-2, TNF-α, and NO using appropriate detection kits. Wilms’ tumour 1 protein expression was measured by Western blotting to determine the anti-leukaemic activity. The inhibition of cell migration was also analyzed to confirm anticancer progression. Results Among the tested extract fraction, ethyl acetate No. 001 displayed strong cytotoxicity specifically in EoL-1 cells, while n-hexane No. 008 demonstrated this effect in three cell lines. Resveratrol, on the other hand, displayed cytotoxicity in all the tested cells. Additionally, the three major compounds, morin, resveratrol, and quercetin, exhibited significant antioxidant and anti-inflammatory properties. In particular, resveratrol demonstrated a noteworthy decreased Wilms’ tumour 1 protein expression and a reduction in cell proliferation across all cells. Moreover, ethyl acetate No. 001, morin, and resveratrol effectively inhibited MCF-7 cell migration. None of these compounds showed any impact on red blood cell haemolysis. Conclusion Based on these findings, it can be concluded that Kae-Lae has promising chemotherapeutic potential against leukaemic cells, with fractional extracts (ethyl acetate and n-hexane) and resveratrol exhibiting the most potent cytotoxic, antioxidant, anti-inflammatory, and anti-cell migration activities.

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Section: Introductionmentioning

confidence: 99%