Morfometria do miocárdio humano em indivíduos senis

Cardoso, José Antonio; Toscano, Ana Elisa; Tashiro, Tetsuo; Carvalho, Cláudio Antonio Ferraz de; Moraes, Sílvia Regina Arruda de

doi:10.1590/s0066-782x2006000500008

Cited by 3 publications

(1 citation statement)

References 23 publications

(19 reference statements)

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“…Similar results 18,19 were observed in ovariectomized and trained rats, and in metabolic syndrome animals 15 subject only to physical training. The hypertrophy of the heart muscle is an attempt to heart adaptation to the overload work 11,20,21 . Increased AST can, in a way, offer improved contractile function of the heart tissue and is an important mechanism in compensatory response to exercise.…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

Brianezi

Marques

Cardoso

et al. 2017

Rev Bras Med Esporte

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Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.

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Section: Discussionmentioning

confidence: 99%

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

Brianezi

Marques

Cardoso

et al. 2017

Rev Bras Med Esporte

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Engineering Cardiac Tissues from Pluripotent Stem Cells for Drug Screening and Studies of Cell Maturation

Miklas

Nunes

Radišić

2013

Israel Journal of Chemistry

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Using cardiomyocytes derived from human pluripotent stem cells (hPSC‐CMs), it is now possible to develop models of human cardiac diseases and to screen novel pharmaceutical agents on human cardiac cells and tissues. However, since hPSC‐CMs display an immature phenotype, significant focus has turned to cardiac tissue engineering to deliver a means to mature these cells. In this review we discuss the maturation state of currently available hPSC‐CMs and provide an overview of the processes involved in cardiomyocyte maturation. We then explore the differences between pathological and physiological hypertrophy and discuss how tissue engineering techniques that rely on the combined use of biomaterials and bioreactors can be utilized to enhance and study the hypertrophic response.

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Physical exercise alters hepatic morphology of low-density lipoprotein receptor knockout ovariectomized mice

et al. 2018

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To explore the effects of physical exercise on the liver of animals in menopause, we analyzed the histomorphometric parameters of the hepatic tissue in ovariectomized and dyslipidemic female mice. The animals were distributed in six groups (n = 5): sedentary control (SC), sedentary ovariectomized control (SOC), trained ovariectomized control (TOC), sedentary LDL knockout (LDL-S), sedentary ovariectomized LDL knockout (LDL-SO), and trained ovariectomized LDL knockout (LDL-TO). At the end of the experiment, the liver and the visceral adipose tissue (VAT) of animals were removed for morphometric and stereological studies. In the LDL-S and LDL-SO animals, both sedentary, results showed reduction in the area (µm) and major and minor diameters (µm) of hepatocytes and reduction in the portions of large hepatocytes, and increase in the percentage of Kupffer cells. The trained group showed a tendency of increase in the area and diameter and in the percentage of hepatocytes, as well significant reduction in the percentage of Kupffer cells and interstitial tissue. We suggested that training can prevent cell and tissue damage caused by the process of increase in hepatic fat, lipoperoxidation, and tissue inflammation in animals with privation of estrogen and dyslipidemia, apparently reflecting a better metabolic response of the hepatic tissue in organisms undergoing training.

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Morfometria do miocárdio humano em indivíduos senis

Cited by 3 publications

References 23 publications

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

Engineering Cardiac Tissues from Pluripotent Stem Cells for Drug Screening and Studies of Cell Maturation

Physical exercise alters hepatic morphology of low-density lipoprotein receptor knockout ovariectomized mice

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