Morfometria de Plantios de Dipteryx odorata Aubl Willd (Cumaru) no Oeste do Pará

Silva, Jéssica Aline Godinho da; Pauletto, Daniela; Silva, Ádria Fernandes da; Carvalho, Cezarina do Socorro de Souza; Nascimento, Hailla Gisely Gomes do

doi:10.34062/afs.v7i3.9263

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The species Dipteryx odorata Aubl Willd known as cumaru, is widely used in folk medicine. Belonging to the Fabaceae family, the plant is called by different names, depending on the region, such as cumaru do Amazonas, cumbari sarrapia, cumaru purple, cumaru-ferro, cumaru da Folha Grande, cumaru true, cumari and internationally it is known as Tonka [5,6,7]. The species attracts great interest due to the uses attributed to it in popular medicine.…”

Section: Introductionmentioning

confidence: 99%

In Silico Study of Organic Compounds from Dipteryx odorata with SARS-COV-2 Targets by Molecular Docking and ADME-TOX Analysis

Souza,

Sousa

et al. 2024

JAMMR

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Introduction: The new coronavirus SARS-CoV-2, identified in December 2019 as the cause of COVID-19, has triggered an outbreak of potentially fatal atypical pneumonia. The constant search for new molecules or strategies to combat this disease continues. Thus, the objective of this work was to evaluate, using in silico methods, the compounds present in Dipteryx odorata as inhibitors of crucial targets of SARS-COV-2. Methodology: The methodology included the selection of plant compounds from the Pubchem database and obtaining the structures of SARS-COV-2 proteins (6vxx, 6lu7, 1R42) from the Protein Data Bank (PDB). The molecular docking analysis was performed using the Autodock Tools 1.5.6 and Autodock Vina programs, LigPlus to obtain amino acids, and Chimera v.13.1 to generate 3D images. The absorption, distribution, metabolism, excretion and toxicity (ADME-TOX) properties of the most promising compounds were evaluated with the pkCSM tool. Results: In total, 672 molecular dockings were carried out, tested with 168 ligands, resulting in 17 compounds with binding energies lower than -7.9 kcal.mol-¹. A highlight was the exceptional interaction of the vouacapenic acid compound with the Spike protein, recording an energy of -9.9 kcal.mol-¹. The study revealed that compounds such as vouacapenic acid, taraxasterol and luteolin showed notable interactions with the Spike protein, in addition to positive results in the ADMET-TOX profile. Conclusion: These findings indicate the potential of these compounds and point to the need for in vivo and in vitro studies to validate their antiviral efficacy as therapeutic agents against SARS-COV-2.

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Section: Introductionmentioning

confidence: 99%

In Silico Study of Organic Compounds from Dipteryx odorata with SARS-COV-2 Targets by Molecular Docking and ADME-TOX Analysis

Souza,

Sousa

et al. 2024

JAMMR

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Dendrometric Relationships and Biomass in Commercial Plantations of Dipteryx spp. in the Eastern Amazon

de Sousa Lopes,

Pauletto,

Gomes

et al. 2023

Forests

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The objective of this study is to characterize and compare the relationships between dendrometric variables in Dipteryx spp. stands in the Western Amazon by fitting linear regression equations for total height (ht) and crown diameter (dc). Six forest stands were evaluated in three municipalities. The variables collected included diameter at 1.3 m height (dbh), ht, and dc. Simple and multiple linear regression equations were fitted to characterize the relationships between ht and dc. The aboveground biomass and carbon stock of the stands were estimated. Most dendrometric variables were positively correlated (97.5%). The general equations presented an R2adj. greater than 0.7, and all coefficients were significant. Equations with non-significant coefficients were common in settlement adjustments (45%). The error for these equations varied between 1.1 and 23.6 m. The trees averaged 22 t ha−1 of aboveground biomass in the stands. There was a variation in carbon sequestration potential among stands, ranging from 5.12 to 88.91 t CO2 ha−1. Single-input equations using dbh as an independent variable are recommended for estimating dc and ht for individual Dipteryx spp. stands. Stands in the Western Amazon play a significant role in carbon sequestration and accumulation. Trees can sequester an average of 4.8 tons of CO2 per year.

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Morfometria de Plantios de Dipteryx odorata Aubl Willd (Cumaru) no Oeste do Pará

Cited by 2 publications

References 15 publications

In Silico Study of Organic Compounds from Dipteryx odorata with SARS-COV-2 Targets by Molecular Docking and ADME-TOX Analysis

In Silico Study of Organic Compounds from Dipteryx odorata with SARS-COV-2 Targets by Molecular Docking and ADME-TOX Analysis

Dendrometric Relationships and Biomass in Commercial Plantations of Dipteryx spp. in the Eastern Amazon

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