More unaffected first-degree relatives of essential tremor cases have mild cognitive deficits than age-matched controls

Meyers, James H.; Hickman, Ruby; Cristal, Ashley D.; Factor-Litvak, Pam; Cosentino, Stephanie; Louis, Elan D.

doi:10.1016/j.parkreldis.2018.10.030

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…At the same time, the abnormal auditory MMN-evoked response reflects impaired working memory, attentional switch as well as automatic pre-attentive discrimination of acoustic changes. These results are passing with the work of Meyers and colleagues, 2019 [16] as well as Novellino and colleagues, 2020 [17] who demonstrated greater cognitive decline not only among ET patients but also their 1st degree relatives. They also identified hippocampal microstructural damage correlated with the ET-associated cognitive impairment and make it as a risk for dementia.…”

Section: Discussionmentioning

confidence: 60%

Essential tremor: what is beyond the oscillatory monosymptomatic illness?

Elhassanien

Rashed

Bahnasy

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background Essential tremor (ET) is now considered as a slowly progressive neurodegenerative disorder with a variety of motor and non-motor manifestations. The objectives of this work were to study the existence of cognitive, mood, olfactory, and balance dysfunctions in ET patients and their relation to tremor severity as well as patients’ activity of daily livings. Methods This study was performed on 36 ET patients and 24 healthy controls subjects (HCS) submitted to The Essential Tremor Rating Assessment Scale (TETRAS), advanced activity of daily living scale (AADLs), Montreal cognitive assessment scale (MoCA), Montgomery–Åsberg Depression Rating Scale (MADRS), auditory mismatch negativity (MMN), Sniffin’ Sticks test (SST), computerized dynamic posturography (CDP), and brain MRI diffusion tensor tractography (DTT). Results ET patients showed significant decrease in AADLs, MoCA, SST (threshold, identification, and discrimination subscales) as well as visual and vestibular ratios of CDP compared to HCS. Auditory MMN showed significant reduction in the amplitude and prolongation of latencies while corticospinal tracts, thalamo-cortical connectivity, and middle cerebellar peduncles DTT revealed reduced fractional anisotropy in ET patients with normal tracts densities. Conclusion ET patients exhibit a wide variety of non-motor manifestations including cognitive impairment, depressive symptoms, hyposmia, and increased risk of falls with consecutive reduced activity of daily living beyond the deleterious effects of the kinetic tremor.

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Section: Discussionmentioning

confidence: 60%

Essential tremor: what is beyond the oscillatory monosymptomatic illness?

Elhassanien

Rashed

Bahnasy

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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“…The included studies relied on a diversity of neuropsychological assessments ( Table 1 ). Ten studies used the MMSE ( 10 , 13 , 15 , 16 , 18 , 21 – 24 , 26 ), two studies used the MoCA ( 25 , 27 ), one used the Hamilton Anxiety Scale (HAMA) and the BDI ( 18 ), one used the HDRS and the HARS ( 20 ), one used the Turkish versions of the HDRS and the Turkish versions of the HARS ( 9 ), six used the clinical assessment ( 11 , 17 – 19 , 23 ), and two used the Diagnostic and Statistical Manual of Mental disorders (DSM) ( 11 , 14 ). These generalized screening instruments assessed global cognitive function, depression, and anxiety.…”

Section: Resultsmentioning

confidence: 99%

Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis

Shang

Chen

et al. 2022

Front. Neurol.

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BackgroundThe dementia and affective disorders are common non-motor features in patients with essential tremor (ET). However, the relationship of ET with cognitive impairments and affective disorders remains controversial. This meta-analysis aimed to analyze the association of ET with dementia and affective disorders.MethodsOriginal studies published from January 1999 to October 2019 were systematically searched from the database of Medline (OvidSP), EMBASE (OvidSP), and the Cochrane Central Register of Controlled Trials. Pooled standard mean difference (SMD, random effect model), odds ratios (ORs), relative risk (RR), and 95% CI were calculated.ResultsCompared with the Non-ET group, patients with ET had significantly lower Mini-Mental State Examination (MMSE) score (SMD, −1.16; 95% CI, −1.75 to −0.58; p = 0.0001) and had significantly higher depressive and anxiety symptoms scale score (SMD, 0.55; 95% CI, 0.22–0.87; p = 0.0009). The OR for dementia and affective disorders in individuals with ET compared with individuals without ET was 2.49 (95% CI, 2.17–2.85, p < 0.00001). While there was no significant difference in Montreal Cognitive Assessment (MoCA) score between ET and Non-ET groups (SMD, −0.52; 95% CI, −0.16 to 0.13; p = 0.23), there was a significant difference in the risk of mortality between ET and Non-ET groups (RR = 4.69, 95% CI, 2.18–10.07).ConclusionThe non-motor symptoms should not be neglected among patients with ET. However, the causal relationship between ET and dementia, depression, and anxiety is unclear.

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“…RULET is a cross-sectional, observational study of environmental factors associated with ET (2000 -present) [15]. ET cases underwent a videotaped neurological examination.…”

Section: Ruletmentioning

confidence: 99%

The Conundrum of Dystonia in Essential Tremor Patients: How does One Classify these Cases?

Bain

Defazio

et al. 2022

Tremor and Other Hyperkinetic Movements

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Background:The relationship between essential tremor (ET) and dystonia has been long debated and the boundaries between these disorders remain unclear. Here, we highlight the diagnostic uncertainty that can arise when observing dystonic postures in patients who have received ET diagnoses.Methods: An international panel of seven movement disorders neurologists from five countries reviewed the clinical history and videotaped neurological examinations of five individuals diagnosed with ET who also had various features of dystonia on neurological examination. Experts were instructed to assign diagnoses and provide their rationale for diagnostic assignments. Results:The five cases each exhibited a variety of abnormal postures. These were observed by all experts, and interpreted as dystonic postures by six experts. According to six of seven experts, all five cases had ET. One expert classified all cases as dystonic tremor rather than ET. One case had cervical dystonia, and five of seven experts assigned dual diagnoses of ET and dystonia in that case. The assignment of dystonia diagnoses was variable among the other four cases, with two to three experts assigning this diagnosis in each case, underscoring differences in diagnostic interpretation of dystonic postures on examination. Conclusions:This study draws attention to some of the differences between experts in assigning diagnoses of ET or dystonia to individuals with ET and abnormal postures. The goal here was not necessarily to build consensus, but to raise issues, highlight areas of uncertainty, and identify areas of common vs. differentiated thought. Several questions for additional research were also raised.

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More unaffected first-degree relatives of essential tremor cases have mild cognitive deficits than age-matched controls

Cited by 5 publications

References 32 publications

Essential tremor: what is beyond the oscillatory monosymptomatic illness?

Essential tremor: what is beyond the oscillatory monosymptomatic illness?

Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis

The Conundrum of Dystonia in Essential Tremor Patients: How does One Classify these Cases?

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