More Than Meets the Eye: a Case of Synchronous Ipsilateral Clear Cell Renal Cell Carcinoma and Urothelial Carcinoma of the Pelvicalyceal System

Symeonidis, Asterios; Tsikopoulos, Ioannis; Symeonidis, Evangelos N.; Tsifountoudis, Ioannis; Michailidis, Antonios; Tsantila, Ioanna; Gkekas, Chrysovalantis; Georgiadis, Christos; Malioris, Apostolos; Papathanasiou, Michail

doi:10.21203/rs.3.rs-482272/v1

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…Radiologic findings are not definitive in the differential diagnosis, and a biopsy should be performed if there is a high suspicion. Especially in cases of hematuria, a suspicion of urothelial carcinoma or a coexistence of RCC with urothelial carcinoma should be suspected [ 34 ]. Nephron-sparing techniques, such as ablation and partial nephrectomy, should be performed in these patients, as most of these patients are young, and renal endometriosis is a benign disease.…”

Section: Discussionmentioning

confidence: 99%

Renal Endometriosis Mimics Renal Cell Carcinoma in a Hypoplastic Kidney: A Case Report

Katsikatsos,

Douroumis,

Goutas

et al. 2024

Cureus

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Renal endometriosis is a rare disorder of cases of urinary tract endometriosis. A 42-year-old woman presented at our outpatient department with an incidental painless mass on her left hypoplastic kidney revealed on an abdominal ultrasound. Abdominal and pelvic examinations revealed no abnormal findings. A computed tomography (CT) scan revealed an anterolateral slightly enhanced left renal mass that measured 1.2 cm in diameter. Furthermore, CT did not reveal any evidence of abdominal or thoracic metastasis. There are a few case reports in the literature of tumors in specimens from patients who underwent nephrectomy for hypoplastic kidneys, but discriminating between benign and malignant masses is difficult unless a nephrectomy is performed. Given the radiological findings and the impaired function of the hypoplastic kidney, laparoscopic radical nephrectomy was recommended. The procedure was performed under general anesthesia without intraoperative or postoperative complications. Microscopic examination revealed several findings consistent with a diagnosis of renal endometriosis. The patient had no symptoms at her last follow-up visit. This case highlights that renal endometriosis can mimic renal cell carcinoma and awareness of this entity should be raised, as it can be asymptomatic, especially when located in a hypoplastic kidney.

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Section: Discussionmentioning

confidence: 99%

Renal Endometriosis Mimics Renal Cell Carcinoma in a Hypoplastic Kidney: A Case Report

Katsikatsos,

Douroumis,

Goutas

et al. 2024

Cureus

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“…Thus, renal cell carcinoma was considered excluded but patient is to have follow up. Vigilance during the workup of such polycystic masses for RCC is important [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic kidney: a case report

Amoah,

Kyei,

Mensah

et al. 2024

J Med Case Reports

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Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder and the fourth cause of death of end-stage renal disease. The disease has a prevalence of 1:400–1:1000 accounting for 10% of patients on dialysis. In most ADPKD patients, bilateral kidneys are similarly affected, with numerous fluid-filled cysts arising from different nephron segments. Only a few cases of ADPKD with ectopic unilateral multicystic kidney have been reported. It has been observed that the deterioration of their kidney function seemed to be quicker than their age- and sex-matched controls and siblings especially when the ectopic kidney is dysplastic. Case presentation We report a case of a 46-year-old Ghanaian male patient who presented with left flank pain and hematuria with high BP and deranged renal function. Abdominal ultrasonography showed both kidneys to be larger than normal and had multiple cysts of varying sizes with the right kidney located in the right iliac fossa. Follow up Abdominopelvic computer tomographic scan (CT–Scan) without contrast showed enlarged kidneys with the renal parenchyma replaced by innumerable cyst of varying sizes. The right kidney was ectopically located in the right aspect of the pelvis. A diagnosis of ADPKD with right pelvic ectopic multicystic kidney was made. He was put on antihypertensives, analgesia for the left flank pain and to have follow up at the urology and nephrology departments. Conclusion In most ADPKD patients, bilateral kidneys are similarly affected. Only a few cases of ADPKD with ectopic unilateral multicystic kidney have been reported. It has been observed that the deterioration of their kidney function seemed to be quicker than their age- and sex-matched controls and siblings especially when the ectopic kidney is dysplastic.

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“…Patients with papillary RCC combined with UCC had a shorter history of ~1 month, with the average maximum diameter of the kidney tumor being ~2 cm and the average maximum diameter of the ureteral tumor being ~2 cm. Patients with clear cell RCC combined with UUC had the second longest history, ~2 months, with an average maximum diameter of ~3 cm for renal tumours and 4 cm for ureteral tumours; patients with CRCC combined with UCC had a longer history, >3 months on average, with an average maximum diameter of ~4 cm for renal tumours and 5 cm for ureteral tumours (Table I) (12)(13)(14)(15)(16). Although the early symptoms of simple kidney cancer are not obvious, and even ~50% of the patients have no discomfort (17).…”

Section: Discussionmentioning

confidence: 99%

Chromophobe renal cell carcinoma with ipsilateral ureteral urothelial carcinoma: A case report

Wang

Liang

2023

Mol Clin Oncol

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It is very rare for different types of urological tumours to occur together, and it is even rarer for chromophobe renal cell carcinoma (CRCC) to be combined with ipsilateral ureteral urothelial carcinoma (UUC), and the symptoms are relatively homogeneous, mostly presenting as symptoms that can be observed in malignant tumours alone, and therefore are often easily missed. In the present study, a case of a patient who was admitted to the hospital for more than 3 months with no obvious cause of terminal carnivorous hematuria was reported, and ureteral carcinoma was considered in the preoperative diagnosis but not renal carcinoma. After completion of preoperative tests, laparoscopic right nephrectomy and right ureterectomy was performed. The postoperative pathological diagnosis was CRCC of the right side and low-grade UUC of the right side, and the patient did not show any significant abnormality at the postoperative follow-up. By discussing this case and reviewing the relevant literature, the present study provides clinicians with more insight.

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More Than Meets the Eye: a Case of Synchronous Ipsilateral Clear Cell Renal Cell Carcinoma and Urothelial Carcinoma of the Pelvicalyceal System

Cited by 6 publications

References 9 publications

Renal Endometriosis Mimics Renal Cell Carcinoma in a Hypoplastic Kidney: A Case Report

Renal Endometriosis Mimics Renal Cell Carcinoma in a Hypoplastic Kidney: A Case Report

Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic kidney: a case report

Chromophobe renal cell carcinoma with ipsilateral ureteral urothelial carcinoma: A case report

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