More than 10 years of speckle tracking echocardiography: Still a novel technique or a definite tool for clinical practice?

Cameli, Matteo; Mandoli, Giulia Elena; Sciaccaluga, Carlotta; Mondillo, Sergio

doi:10.1111/echo.14339

Cited by 76 publications

(84 citation statements)

References 89 publications

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“…Global longitudinal strain (GLS) is a well-known index of LV systolic function and is sensitive to subendocardial fiber impairment [ 21 ]. So, it can be beneficial to monitor subclinical myocardial dysfunction in the early stages of several diseases such as hypertension, diabetes, ischemic heart diseases, and cardiotoxic chemotherapy; meanwhile, LVEF is still preserved [ 22 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Global longitudinal strain can be measured by multiple methods, including speckle-tracking echocardiography (STE), tissue Doppler imaging (TDI), and cardiovascular magnetic resonance (CMR) [ 21 ]. Speckle-tracking echocardiography is a newer, cost-effective, and reliable method for assessing LV systolic function, compared with tissue Doppler imaging and cardiovascular magnetic resonance [ 21 ]. Therefore, we used STE to detect the subclinical systolic dysfunction of LV in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study

Hai

Phuong

Dung

et al. 2020

Critical Care Research and Practice

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Introduction. Left ventricular dysfunction is quite common in septic shock. Speckle-tracking echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional echocardiography. We sought to evaluate subclinical left ventricular systolic function in patients with septic shock using speckle-tracking echocardiography. Methods. From May 2017 to December 2018, patients aged ≥18 years admitted to the intensive care unit with the diagnosis of sepsis and septic shock based on the sepsis-3 definition were included. Patients with other causes of cardiac dysfunction were excluded. Transthoracic echocardiography was performed for all the patients within 24 hours of diagnosis. Left ventricular systolic function was assessed using conventional echocardiography and speckle-tracking echocardiography. Results. Patients with septic shock (n = 90) (study group) and 37 matched patients with sepsis but no septic shock (control group) were included. Left ventricular ejection fraction (LVEF) by conventional echocardiography showed no significant difference between two groups (58.2 ± 9.9 vs. 58.6 ± 8.3, p=0.804). The global longitudinal strain (GLS) by STE was significantly reduced in patients with septic shock compared with that in the control (−14.6 ± 3.3 vs. −17.1 ± 3.3, p<0.001). Based on the cutoff value of GLS ≥ −15% for the definition of subclinical left ventricular systolic dysfunction, this dysfunction was detected in 50 patients with septic shock (55.6%) and in 6 patients in the control group (16.2%) (p<0.05). Conclusions. Speckle-tracking echocardiography can detect early subclinical left ventricular systolic dysfunction via the left ventricular global longitudinal strain compared with conventional echocardiographic parameters in patients with septic shock.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study

Hai

Phuong

Dung

et al. 2020

Critical Care Research and Practice

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“…The study of LA function gained attention in recent years, mostly due to deformation imaging and to the growing evidence of prognostic value of the method. Speckle tracking echocardiography (STE), which assesses the LA longitudinal deformation, is the most promising technique for direct evaluation of LA function [2]. It offers opportunities to measure quantitative parameters of LA function but still lacks clear standardization in this setting.…”

Section: Introductionmentioning

confidence: 99%

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Cameli

Miglioranza²,

Magné

et al. 2020

Diagnostics

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Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subjects, patients with arterial hypertension or aortic stenosis (LA pressure overload, group 2) and patients with mitral regurgitation or heart failure (LA volume–pressure overload, group 3). Difference between the inter-correlation coefficient (ICC) by the two echocardiographers using the two techniques, feasibility and analysis time of both methods were analyzed. A total of 938 subjects were included: 309 controls, 333 patients in group 2, and 296 patients in group 3. The ICC was comparable between QRS-LASr (0.93) and P-LASr (0.90). The young echocardiographers calculated QRS-LASr in 90% of cases, the expert ones in 95%. The feasibility of P-LASr was 85% by young echocardiographers and 88% by senior ones. QRS-LASr young median time was 110 s (interquartile range, IR, 78-149) vs senior 110 s (IR 78-155); for P-LASr, 120 s (IR 80-165) and 120 s (IR 90-161), respectively. LA strain was feasible in the majority of patients with similar reproducibility for both methods. QRS complex guaranteed a slightly higher feasibility and a lower time wasting compared to the use of P wave as the reference.

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“…Early impairment of other indices of left ventricular systolic function using tissue Doppler imaging, before any remarkable reduction in left ventricular ejection fraction, has already been reported [16,19,20]. In this direction, echocardiographic deformational analysis [21] in TM patients aims to detect early changes in cardiac mechanics before any observed reduction in LVEF. This strategy could potentially prompt a change in the patient's therapeutic strategy.…”

Section: Discussionmentioning

confidence: 93%

Left ventricular deformation mechanics over time in patients with thalassemia major with and without iron overload

Bonios

Fountas

Delaporta

et al. 2021

BMC Cardiovasc Disord

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Background Myocardial iron overload in patients with thalassemia major (TM) is one of the most important complications. The purpose of the study was to identify advanced echocardiography parameters for early identification of myocardial dysfunction during follow-up of patients with TM. Methods Forty TM patients who were 41 ± 5 years old were included in the study and divided into two groups according to cardiac magnetic resonance T2* results (Group 1: Τ2* > 25 ms, Group 2: Τ2* ≤ 25 ms). Liver T2* parameters were also measured. Conventional and deformational echocardiographic parameters were measured at baseline and approximately 2 years later. Results Thirty-two patients had Τ2* = 34 ± 4 ms (Group 1), and 8 had Τ2* = 17 ± 9 ms (Group 2). Blood consumption was 185 ± 60 and 199 ± 37 ml/kg/yr (p = 0.64), and liver T2* was 4 ± 5 and 17 ± 21 ms (p = 0.01) in Groups 1 and 2, respectively. At baseline, Group 1 had better left ventricular global longitudinal strain (GLS) (− 22 ± 3 vs. − 18 ± 5, p = 0.01) and similar left ventricular ejection fraction (LVEF) (62 ± 5% vs. 58 ± 10%, p = 0.086) than Group 2. At the 28 ± 11-month follow-up, LVEF, GLS, and T2* values in Group 1 (63 ± 3%, − 21 ± 3%, 34 ± 4 ms) and Group 2 (56 ± 11%, − 17 ± 4%, 17 ± 9 ms) did not change significantly compared to their corresponding baseline values. In 8 patients from Group 1, a worsening (> 15%) in LS (p = 0.001) was detected during follow-up, with a marginal reduction in LVEF. Conclusions GLS seems to be an efficient echocardiographic parameter for detecting hemochromatosis-related cardiac dysfunction earlier than LVEF. It also seems to be affected by other factors (free radical oxygen, immunogenetic mechanisms or viral infections) in a minority of patients, underscoring the multifactorial etiology of cardiomyopathy.

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More than 10 years of speckle tracking echocardiography: Still a novel technique or a definite tool for clinical practice?

Cited by 76 publications

References 89 publications

Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study

Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Left ventricular deformation mechanics over time in patients with thalassemia major with and without iron overload

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