More severe white matter changes in the elderly with jugular venous reflux

Chung, Chih‐Ping; Wang, Pei Ning; Wu, Yi Hui; Yp, Tsao; Sheng, Wen‐Yung; Lin, Ker Neng; Lin, Shing Jong; Hu, Han Hwa

doi:10.1002/ana.22276

Cited by 65 publications

(82 citation statements)

References 40 publications

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“…A recent study found a strong correlation between jugular venous reflux and age-related white matter changes in elderly healthy subjects. 28 Although a significant relationship was found between the number of functional and the number of intra-and extraluminal abnormalities, this relationship could explain, at best, only 20% of the variance. In addition, modest-to-high intrarater agreement for the detection of type and number of functional abnormalities was not observed for inter-rater agreement.…”

Section: Discussionmentioning

confidence: 94%

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

Dolić

Marr²,

Valnarov³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of the main extracranial cerebrospinal venous routes that interfere with normal venous outflow. Research into CCSVI will determine its sensitivity and specificity for a diagnosis of MS, its prevalence in MS patients, and its clinical, MRI, and genetic correlates. Our aim was to investigate the prevalence and number of intra-and extraluminal structural and functional extracranial venous abnormalities by using DS and MRV, in patients with MS and HCs.

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Section: Discussionmentioning

confidence: 94%

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

Dolić

Marr²,

Valnarov³

et al. 2011

AJNR Am J Neuroradiol

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“…36 Even more recently, the same group of investigators showed that subjects with severe internal jugular vein reflux had more severe age-related WM changes on MR imaging, especially in caudal brain regions. 37 Therefore, the effect of CCSVI-related abnormalities in relation to WM changes in the brain parenchyma has to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

No Association Between Conventional Brain MR Imaging and Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis

Zivadinov

Cutter

Marr

et al. 2012

AJNR Am J Neuroradiol

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“…The jugular venous valves, which are located at the enlarged jugular bulb near the junction with the innominate vein, prevent the transmission of thoracic pressure and reflux of venous blood into the cerebral circulation. 17,35 The development of internal jugular vein valve incompetence usually follows an increase in central venous pressure, 20,36 which involves a series of pulmonary diseases (such as chronic obstructive pulmonary diseases and pulmonary hypertension), heart diseases (such as congestive heart failure and valvular heart diseases), and central venous system obstruction. 20 All of the above-mentioned disorders have a high rate of internal jugular vein valve incompetence.…”

Section: Discussionmentioning

confidence: 99%

Chronic Influences of Obstructive Sleep Apnea on Cerebral Venous Flow

Lin²,

Hsu

et al. 2015

J of Ultrasound Medicine

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bstructive sleep apnea (OSA) syndrome is highly associated with cardiovascular morbidities. [1][2][3][4][5] These patients have recurrent inspiratory flow arrest during sleep and regain inspiration after forcefully expanding the thoracic cages, using a Müller-like maneuver. 6 This unique respiratory pattern (cyclic apnea and a hypoxic reaction) causes swings in the heart rate, blood pressure, and cardiac output; finally, grave disorders involving the pulmonary, cardiovascular, hormonal, central nervous system ensue. 2,3,7 Focusing on its effect on the central neural system, it is known that perfusion of the cerebral arteries is decreased either during sleep or while awake, [8][9][10] and OSA syndrome is considered a risk factor for cerebral vascular accidents. 1,4,11,12 Results of several studies have suggested that the more negative intrapulmonary pressure in patients -Yi Chi, MD, Chang-Sheng Lin, MD, Min-hsien Hsu, MD, Po-chi Chan, MD, Han-Hwa Hu, MD Received December 31, 2014, Hsin ORIGINAL RESEARCHObjectives-Evidence reveals a pathophysiologic link between sleep apnea syndrome and cerebrovascular diseases. It is known that obstructive sleep apnea (OSA) may cause serial hemodynamic changes and structural abnormalities in the cerebral and cardiac arterial systems, but its effect on the cerebral venous system has remained unclear. The purpose of this study was to compare internal jugular vein hemodynamics between patients with OSA and healthy individuals.Methods-Patients with OSA and age-, body mass index-, and sex-matched healthy control participants were recruited for a jugular venous duplex study and neurologic examination. The luminal area of the internal jugular vein, jugular venous flow volume, time-averaged mean velocity, and presence of jugular venous reflux were recorded. These flow characteristics were obtained at different respiratory statuses, and we analyzed the differences between patients and controls.Results-In the OSA group, there was an increasing flow volume in total internal jugular veins at rest. The frequency of venous reflux in patients compared with controls was significantly decreased (26.7% versus 53.3%, respectively; P < .05). The internal jugular vein drainage dominance was greater on the left side in the OSA group (right versus left: 48.8% versus 51.2%), whereas it was greater on the right side in the control group (right versus left: 61.7% versus 38.3%).Conclusions-Our data showed peculiar internal jugular vein hemodynamics at baseline and different respiratory statuses in patients with OSA. These characteristics imply that cerebral venous drainage conditions might be involved in the pathophysiologic mechanisms of OSA syndrome.

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More severe white matter changes in the elderly with jugular venous reflux

Cited by 65 publications

References 40 publications

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

Intra- and Extraluminal Structural and Functional Venous Anomalies in Multiple Sclerosis, as Evidenced by 2 Noninvasive Imaging Techniques

No Association Between Conventional Brain MR Imaging and Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis

Chronic Influences of Obstructive Sleep Apnea on Cerebral Venous Flow

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