More Research Is Needed to Investigate the Effect of Denervation on Blood Pressure

Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation?

“…3 The 11 trials cited above, [3][4][5][6][7][8][9][10][11][12][13] together with the SYMPLICITY HTN-3 trial, 2 clearly demonstrate that renal denervation is not effective for lowering blood pressure in every patient with resistant hypertension, highlighting the need to identify predictors of the blood-pressure response to renal denervation. 17 A major limitation of the reported clinical trials on renal denervation is that the baseline sympathetic tone of patients has not been investigated. Renal denervation was designed to lower blood pressure by inhibiting the increased sympathetic tone commonly observed in patients with hypertension and, therefore, might not be effective in patients whose sympathetic tone is not increased.…”