More optimal but less regulated dorsal and ventral visual networks in patients with major depressive disorder

Chen, Hui; Li, Kai; Zhang, Bin; Zhang, Jingyu; Xue, Xiang; Lin, Yong; Zou, Danfeng; Chen, Menglin; Kong, Youyong; Wen, Gen; Yan, Jun; Deng, Yaotang

doi:10.1016/j.jpsychires.2019.01.005

Cited by 37 publications

(23 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MDD patients with higher negative affect also exerted less inhibitory influence from left dorsolateral prefrontal cortex to right fusiform gyrus. These results are compatible with previous studies reporting decreased functional connectivity between frontal and visual regions in MDD patients during an emotional task (65-66) and at resting-state (67)(68)(69). The lateral prefrontal cortex plays an important role in the integration of cognitive and emotional information (70)(71) and inhibition of task-irrelevant stimuli (72)(73)(74).…”

Section: Disease Statesupporting

confidence: 92%

Effective connectivity during faces processing in major depression – distinguishing markers of pathology, risk, and resilience

Sacu

Wackerhagen

Erk

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Aberrant brain connectivity during emotional processing, especially within the fronto-limbic pathway, is one of the hallmarks of major depressive disorder (MDD). However, a lack of systematic approaches in previous studies made it difficult to determine whether a specific alteration in brain connectivity reflects a cause, correlate, or effect of the disorder. The current study aimed to investigate neural mechanisms that correspond to disease, risk and resilience in major depression during implicit processing of emotion cues. Methods: Forty-eight patients with MDD, 49 first-degree relatives of patients with MDD and 103 healthy controls performed a face-matching task during functional magnetic resonance imaging. We used dynamic causal modelling to estimate task-dependent effective connectivity at the subject level. Parametric empirical Bayes was then performed to quantify group differences in effective connectivity. Results: Depressive pathology was associated with decreased effective connectivity from the left amygdala and left dorsolateral prefrontal cortex to the right fusiform gyrus, whereas familial risk for depression corresponded to decreased connectivity from the right orbitofrontal cortex to the left insula and from the left orbitofrontal cortex to the right fusiform gyrus. Resilience for depression was related to increased connectivity from the anterior cingulate cortex to the left dorsolateral prefrontal cortex. Conclusions: Our results suggest that the depressive state alters top-down control of higher visual regions during the processing of emotional faces, whereas increased connectivity within the cognitive control network promotes resilience to depression.

show abstract

Section: Disease Statesupporting

confidence: 92%

Effective connectivity during faces processing in major depression – distinguishing markers of pathology, risk, and resilience

Sacu

Wackerhagen

Erk

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…While depression is not typically considered a disorder of dysfunctional sensory processing, somatic symptoms in depression have been well described 65 , and there are reports of both visual 66 and auditory 67 processing deficits in depression. Our results contribute to a growing body of literature documenting associations of depression with altered structure 12 and functional connectivity 68,69 in sensory regions. These findings may point to disrupted information transfer in sensory regions a part of the underlying neurobiological etiology of depression.…”

Section: Discussionsupporting

confidence: 66%

“…Intriguingly, there are several examples in our results where proximal or similar regions had effects in opposing directions, including in the anterior cingulate (left p32 was increased, while left a24pr and left 24dv were decreased), the superior parietal cortex (left 7PC was increased and right 7AL was decreased), the retroinsular cortex (right RI was increased and left RI was decreased), and in visual processing regions (left MT and left MST were increased, and left V4t, which they border, was decreased). While the relationship between cortical myelin and functional activation or connectivity remains under-explored, these observations suggest that cortical myelin imbalance, rather than a global reduction, could drive some of the observed functional differences in depression, such as disrupted network integration 69,70 and patterns of both hypo- and hyper-connectivity 71,72 .…”

Section: Discussionmentioning

confidence: 99%

Aberrant levels of cortical myelin distinguish individuals with unipolar depression from healthy controls

Baranger

Halchenko

Satz

et al. 2021

Preprint

View full text Add to dashboard Cite

The association of unipolar depression (UD), relative to healthy controls (HC), with cortical myelin is underexplored, despite growing evidence of associations with white matter tract integrity. We characterized cortical myelin in the 360 Glasser atlas regions using the T1w/T2w ratio in 39 UD and 47 HC participants (ages=19-44, 75% female). A logistic elastic net regularized regression with nested cross-validation and a subsequent linear discriminant analysis conducted on held-out samples were used to classify UD vs. HC. True-label model performance was compared against permuted-label model performance. Cortical myelin distinguished UD from HC with 68% accuracy (p<0.001; sensitivity=63.8%, specificity=71.5%). Consistently selected regions were located in the orbitofrontal cortex, anterior cingulate, extended visual, and auditory cortices, and showed statistically significant both decreases and increases in myelin levels in UD vs. HC. The patterns of cortical myelin in these regions may be a biomarker of UD.

show abstract

“…A study in college students with nonclinical depression suggested that alterations in these regions might be associated with abnormal emotional control of visual information processing ( Wei et al, 2014 ). Despite the scarce literature implicating abnormalities in the VIS network, several studies have shown that depression can profoundly modify the visual and visual-attentional systems ( Veer et al, 2010 ; Sacchet et al, 2016 ; Chen et al, 2019 ; Moreno-Ortega et al, 2019 ). For example, Moreno-Ortega et al (2019) showed that the reduced VIS network connectivity found in patients with depression reversed after successful electroconvulsive therapy.…”

Section: Discussionmentioning

confidence: 99%

The Dynamics of Functional Brain Networks Associated With Depressive Symptoms in a Nonclinical Sample

Alonso

Deco

Horst

et al. 2020

Front. Neural Circuits

View full text Add to dashboard Cite

Brain function depends on the flexible and dynamic coordination of functional subsystems within distributed neural networks operating on multiple scales. Recent progress has been made in the characterization of functional connectivity (FC) at the whole-brain scale from a dynamic, rather than static, perspective, but its validity for cognitive sciences remains under debate. Here, we analyzed brain activity recorded with functional Magnetic Resonance Imaging from 71 healthy participants evaluated for depressive symptoms after a relationship breakup based on the conventional Major Depression Inventory (MDI). We compared both static and dynamic FC patterns between participants reporting high and low depressive symptoms. Between-group differences in static FC were estimated using a standard pipeline for networkbased statistic (NBS). Additionally, FC was analyzed from a dynamic perspective by characterizing the occupancy, lifetime, and transition profiles of recurrent FC patterns. Recurrent FC patterns were defined by clustering the BOLD phase-locking patterns obtained using leading eigenvector dynamics analysis (LEiDA). NBS analysis revealed a brain subsystem exhibiting significantly lower within-subsystem correlation values in more depressed participants (high MDI). This subsystem predominantly comprised connections between regions of the default mode network (i.e., precuneus) and regions outside this network. On the other hand, LEiDA results showed that high MDI participants engaged more in a state connecting regions of the default mode, memory retrieval, and frontoparietal network (p-FDR = 0.012); and less in a state connecting mostly the visual and dorsal attention systems (p-FDR = 0.004). Although both our analyses on static and dynamic FC implicate the role of the precuneus in depressive symptoms, only including the temporal evolution of BOLD FC helped to disentangle over time the distinct configurations in which this region plays a role. This finding further indicates that a holistic understanding of brain function can only be gleaned if the temporal dynamics of FC is included.

show abstract

More optimal but less regulated dorsal and ventral visual networks in patients with major depressive disorder

Cited by 37 publications

References 37 publications

Effective connectivity during faces processing in major depression – distinguishing markers of pathology, risk, and resilience

Effective connectivity during faces processing in major depression – distinguishing markers of pathology, risk, and resilience

Aberrant levels of cortical myelin distinguish individuals with unipolar depression from healthy controls

The Dynamics of Functional Brain Networks Associated With Depressive Symptoms in a Nonclinical Sample

Contact Info

Product

Resources

About