More on: on the molecular mechanisms for the highly procoagulant pattern of C6 glioma cells

Solly, Françoise; Pernod, Gilles

doi:10.1111/j.1538-7836.2006.02129.x

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[28][29][30][31][32][33] Although further studies would be needed to support this hypothesis, we previously described the in vitro potential of C6 cells to form vascular-like networks on Matrigel, which were resistant to angiostatin as well as to plasma treated with the combination of rtPA and captopril. 34 Figure 7 Tumor volume (mm 3 ). Tumors were measured on day 9, day 11 and day 14 post-implantation.…”

Section: Discussionmentioning

confidence: 99%

Tissue-type plasminogen activator has antiangiogenic properties without effect on tumor growth in a rat C6 glioma model

et al. 2008

View full text Add to dashboard Cite

Tissue-type plasminogen activator (tPA) plays a major role in the fibrinolytic system. According to several reports, tPA may also have antiangiogenic properties, especially in combination with a free sulfhydryl donor (FSD). In the rat C6 glioma model, in vitro and in vivo tPA synthesis by glioma cells is enhanced by differentiation therapy. To address the antiangiogenic potential of tPA in this model, tPA was overexpressed in glioma tumors by ex vivo transduction of C6 cells with a lentiviral vector encoding tPA. The transduced cells were subcutaneously implanted into nude mice. Gene transfer allowed for efficient synthesis of tPA by the C6 tumors. Although the treatment of tPA þ tumor-bearing animals with the FSD captopril generated angiostatin in situ and reduced endothelial vascularization of the tumors, it had no effect on tumor growth. Alternative mechanisms could account for this lack of effect and consequently have important implications for vascular the treatment of glioblastoma.

show abstract