More Liberal “with Mixed Features” Threshold for Bipolar Depression May Be Not Only More Inclusive, But Also More Clinically Relevant.

Kim, W.; Ketter, T.A.

doi:10.1016/s0924-9338(15)30355-2

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, this nosologic change was judged to be controversial by several authors and much of the criticism focused on the diagnostic subtype of the MDE "with mixed features". Indeed, the threshold number of symptoms was deemed arbitrary, as was the choice to retain as mixed features only those manifestations belonging to the manic polarity, and excluding the so-called "overlapping symptoms" such as irritability, psychomotor agitation, and distractibility [17][18][19]. As remarked by several psychopathologists, the DSM neo-Leonhardian taxonomy of mood disorders, based on polarity (depression and mania as extreme poles of a bipolar dichotomy) rather than on the course and recurrence of the episode, constitutes a theoretical model, per se, unsuitable to offer a diagnostic prototype that would properly target the complexity of mixedness in the real-world clinical setting [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Exploration of mood spectrum symptoms during a major depressive episode: The impact of contrapolarity—Results from a transdiagnostic cluster analysis on an Italian sample of unipolar and bipolar patients

et al. 2022

View full text Add to dashboard Cite

Background Subthreshold hypomania during a major depressive episode challenges the bipolar-unipolar dichotomy. In our study we employed a cross-diagnostic cluster analysis - to identify distinct subgroups within a cohort of depressed patients. Methods A k-means cluster analysis— based on the domain scores of the Mood Spectrum Self-Report (MOODS-SR) questionnaire—was performed on a data set of 300 adults with either bipolar or unipolar depression. After identifying groups, between-clusters comparisons were conducted on MOODS-SR domains and factors and on a set of sociodemographic, clinical and psychometric variables. Results Three clusters were identified: one with intermediate depressive and poor manic symptomatology (Mild), one with severe depressive and poor manic symptomatology (Moderate), and a third one with severe depressive and intermediate manic symptomatology (Mixed). Across the clusters, bipolar patients were significantly less represented in the Mild one, while the DSM-5 “Mixed features” specifier did not differentiate the groups. When compared to the other patients, those of Mixed cluster exhibited a stronger association with most of the illness-severity, quality of life, and outcomes measures considered. After performing pairwise comparisons significant differences between “Mixed” and “Moderate” clusters were restricted to: current and disease-onset age, psychotic ideation, suicidal attempts, hospitalization numbers, impulsivity levels and comorbidity for Cluster B personality disorder. Conclusions In the present study, a clustering approach based on a spectrum exploration of mood symptomatology led to the identification of three transdiagnostic groups of patients. Consistent with our hypothesis, the magnitude of subthreshold (hypo)manic symptoms was related to a greater clinical severity, regardless of the main categorical diagnosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Exploration of mood spectrum symptoms during a major depressive episode: The impact of contrapolarity—Results from a transdiagnostic cluster analysis on an Italian sample of unipolar and bipolar patients

et al. 2022

View full text Add to dashboard Cite

show abstract

More Liberal “with Mixed Features” Threshold for Bipolar Depression May Be Not Only More Inclusive, But Also More Clinically Relevant.

Abstract: Aims: Assess prevalence and clinical relevance of 'with mixed features" using a more liberal (2 opposite pole symptoms) compared to the more conservative DSM-5 (3 opposite pole symptoms) threshold in depressed bipolar disorder (BD) patients.

Cited by 1 publication

References 0 publications

Exploration of mood spectrum symptoms during a major depressive episode: The impact of contrapolarity—Results from a transdiagnostic cluster analysis on an Italian sample of unipolar and bipolar patients

Exploration of mood spectrum symptoms during a major depressive episode: The impact of contrapolarity—Results from a transdiagnostic cluster analysis on an Italian sample of unipolar and bipolar patients

Contact Info

Product

Resources

About