More insights into the pharmacological effects of artemisinin

Zyad, Abdelmajid; Tilaoui, Mounir; Jaafari, Abdeslam; Oukerrou, Moulay Ali; Mouse, Hassan Aît

doi:10.1002/ptr.5958

Cited by 59 publications

(42 citation statements)

References 151 publications

(184 reference statements)

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“…Once cytomembranes are destroyed, cells death results [15]. Furthermore, artemisinin can also induce apoptosis [14]: arrest the cell cycle particularly at the G0/G1 phases, inhibits angiogenesis, proliferation and migration of vascular endothelial cells and it seems to have also an effect on immune system functions [35]. Artemisinin belongs to the family of sesquiterpene lactones, with an endoperoxide bridge with great importance for its activity [35].…”

Section: In Vivo Antitumour Activity Analysis Of Tumour Growth Paramementioning

confidence: 99%

“…Furthermore, artemisinin can also induce apoptosis [14]: arrest the cell cycle particularly at the G0/G1 phases, inhibits angiogenesis, proliferation and migration of vascular endothelial cells and it seems to have also an effect on immune system functions [35]. Artemisinin belongs to the family of sesquiterpene lactones, with an endoperoxide bridge with great importance for its activity [35]. Although, the exact mechanism of action of artemisinin has not yet been fully elucidated, the C-radical hypothesis has become one of the most widely accepted theories.…”

Section: In Vivo Antitumour Activity Analysis Of Tumour Growth Paramementioning

confidence: 99%

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Artemisia Annua L. Extract: A New Phytoproduct With Sod-Like and Antitumour Activity

Stan¹

2020

FARMACIA

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The purpose of the present study was to investigate the antitumour potential of Artemisia annua L., harvested from Romania, Bihor area. Artemisinin, quercetin and galic acid have been identified using the LC-MS method. Hypothesis that Artemisia annua L. antitumour effect relays on the modulation of antioxidant activity of SOD has been tested using the SOD defective S. cerevisiae model. According to our results, Artemisia annua L. revealed a selective inhibitory effect on tumour cells of WM35 melanoma cell line in vitro, with a calculated IC50 three times lower as compared to normal HDF fibroblasts. Also, in vivo studies on Ehrlich carcinoma model revealed the amplification effect of Artemisia annua L. on the cytostatic effect of doxorubicin. On both in vivo and in vitro models, the inhibition of the tumour cell proliferation was associated with inhibition of the activities of antioxidative enzymes activities, thus antitumour effect of Artemisia annua L. might be related to oxidative alterations in malignant cells. Rezumat Scopul studiului a fost de a investiga potențialul antitumoral al Artemisiei annua L., plantă recoltată din Romania, județul Bihor. Artemisinina, quercetina și acidul galic au fost identificate prin analiză LC-MS. Utilizând S. cerevisiae, am testat ipoteza că efectul antitumoral al Artemisia annua L. este corelat cu modularea activității antioxidante a SOD. In vitro, pe linia celulară de melanom (WM35), Artemisia annua L. a inhibat selectiv celulele tumorale, IC50 fiind de trei ori mai scăzut decât pentru fibroblastele normale (HDF). Studiile in vivo pe carcinomul ascitic Ehrlich au indicat faptul că Artemisia annua L. potențează efectul citostatic al doxorubicinei. Atât in vivo cât și in vitro, inhibarea proliferării tumorale a fost corelată cu inhibarea activității enzimelor antioxidante, astfel efectul antitumoral al Artemisia annua L. poate fi în legătură cu alterările oxidative de la nivelul celulelor tumorale.

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Section: In Vivo Antitumour Activity Analysis Of Tumour Growth Paramementioning

confidence: 99%

Section: In Vivo Antitumour Activity Analysis Of Tumour Growth Paramementioning

confidence: 99%

Artemisia Annua L. Extract: A New Phytoproduct With Sod-Like and Antitumour Activity

Stan¹

2020

FARMACIA

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“…People from China, as well as those from some other ancient cultures, such as those in India and Africa, have continuously used their traditional alternative medicines. Some well-studied therapeutic compounds, such as artemisinin [16] and soy isoflavones [17], were derived from traditional Chinese herbal medicines. However, these medicinal herbs are generally administered by prescriptions.…”

Section: Introductionmentioning

confidence: 99%

Zhibaidihuang Decoction Ameliorates Cell Oxidative Stress by Regulating the Keap1‐Nrf2‐ARE Signalling Pathway

Ding

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Zhibaidihuang decoction (ZBDHD) is a Chinese herbal formula, which is used in Chinese traditional medicine to treat symptoms of Yinxuhuowang (Yin deficiency and high fire) syndrome. This study elucidates the mechanism of ZBDHD on oral ulcers, one Yinxuhuowang syndrome. Simultaneously, some ingredients in ZBDHD were found and identified by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). A Ganjiangfuzirougui decoction- (GJD-) induced Yinxuhuowang syndrome SD rat model was used to demonstrate the efficiency of ZBDHD treatment. The oral mucosa of rat in the GJD group, stained with hematoxylin and eosin (H&E), showed epidermal shedding and inflammatory cell infiltration. And an alleviation efficiency of ZBDHD in GJD-induced pathological changes in the oral mucosa could be obtained. ZBDHD treatment restored the GJD-induced imbalance of metabolites, which were choline, glycocholic acid, and palmitoyl-L-carnitine (PALC). GJD stimulated the expression of NF-κB. And the overexpressed of NF-κB in mucosa of rat in the GJD group could be inhibited by ZBDHD treatment. Simultaneously, the optimal efficiency of ZBDHD treatment on the cellular ATP content, oxygen consumption rate (OCR), and superoxide dismutase (SOD) concentration was evaluated, in vitro assay. Compared to the control cells, the ATP content, OCR, and SOD activity in the ZBDHD-treated cells were significantly higher. For the mechanisms study, seven cytokines were screened with a Dual-Luciferase Reporter gene assay. In the ARE assay, the luciferase signal was stimulated significantly by ZBDHD. In cells, the transcription of nrf2, maf, and keap1, which were related to the ARE pathway, was elevated by ZBDHD treatment. Our study demonstrated that high-dose GJD could lead to Yinxuhuowang syndrome, such as oral ulcers, and the imbalance in serum metabolites. And ZBDHD can improve oral cell inflammation and the imbalance of metabolism by inhibiting NF-κB and enhancing the activity of the ARE signalling pathway to ameliorate oxidative stress in the cell. This study provides a theoretical basis for the clinical application of ZBDHD.

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“…Artemisinin is a sesquiterpene lactone isolated from a plant called sweet wormwood (Artemisia annua L.) which has been used in Chinese herbal medicine as a remedy for malaria and fevers [19]. Several derivatives of artemisinin including artesunate, arteether and artemether have been synthesized in attempts to enhance its effectiveness and utility [20,21]. Artemisinin and its analogs, which are commonly used in the treatment of severe and complicated drug-resistant malaria strains, have also antitumor activity in cell lines [22].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

et al. 2019

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Artemisinin, an antimalarial drug, has anticancer activity and possesses protective effects against several tissue injuries. The aim of the present study was to investigate the effects of artemisinin on doxorubicin-induced renal and testicular toxicity in rats. Doxorubicin was administered to rats at a single dose of 10 mg/kg body weight (b.w.) as a single intraperitoneal injection. Application of artemisinin was by using oral gavage feeding needle for 14 days at different specified doses (7 mg/kg and 35 mg/kg b.w.). At the end of the experiments, kidney and testis samples were collected and used for histopathological and immunohistochemical examinations. At histopathological examination, while hyperemia was the marked finding in kidney and testis of rats treated with doxorubicin only, no evidence of structural abnormalities showed in other groups. Immunohistochemical examination of the testes and kidneys demonstrated significantly increased expression of caspase-3, TNF-α, iNOS and NF-κB in rats treated with doxorubicin only. Artemisinin decreased the doxorubicin-induced overexpression of NF-κB, iNOS, TNFα and caspase-3 in these tissues of rats. Artemisinin can protect the kidney and testis against doxorubicin-induced nephrotoxicity and testotoxicity, probably through a decrease of caspase-3, TNF-α, iNOS and NF-κB expressions. It may be concluded that artemisinin has a potential for clinical use in the treatment of kidney and testis damage induced by doxorubicin. Further researches are required to determine the appropriate combination of artemisinin with doxorubicin.

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More insights into the pharmacological effects of artemisinin

Cited by 59 publications

References 151 publications

Artemisia Annua L. Extract: A New Phytoproduct With Sod-Like and Antitumour Activity

Artemisia Annua L. Extract: A New Phytoproduct With Sod-Like and Antitumour Activity

Zhibaidihuang Decoction Ameliorates Cell Oxidative Stress by Regulating the Keap1‐Nrf2‐ARE Signalling Pathway

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

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