More hypoglycemia not associated with increasing estimated adiposity in youth with type 1 diabetes

Sarteau, Angelica Cristello; Kahkoska, Anna R.; Crandell, Jamie; Igudesman, Daria; Corbin, Karen D.; Kichler, Jessica C.; Maahs, David M.; Muntis, Frank; Pratley, Richard E.; Seid, Michael; Zaharieva, Dessi P.; Mayer‐Davis, Elizabeth J.

doi:10.1038/s41390-022-02129-1

Cited by 2 publications

(3 citation statements)

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“…In this study, nearly three-fourths of male participants reported experiencing hypoglycemia, whereas a significantly lower proportion of female participants reported similar episodes. A recent investigation by Sarteau, Kahkoska [31] has also identified a higher prevalence of hypoglycemia in males with type 1 diabetes compared to females. Nevertheless, the reasons for this gender disparity remain unclear and may stem from diverse factors such as variations in insulin sensitivity, sex hormones, or behavioral aspects.…”

Section: Sample Representativitymentioning

confidence: 94%

“…Nevertheless, the reasons for this gender disparity remain unclear and may stem from diverse factors such as variations in insulin sensitivity, sex hormones, or behavioral aspects. Studies have posited that males may face an elevated risk of hypoglycemia due to heightened insulin requirements, increased physical activity, and less frequent monitoring of blood glucose levels [31].…”

Section: Sample Representativitymentioning

confidence: 99%

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Hypoglycemic episodes among type 1 diabetic patients in Unaizah, Saudi Arabia: causes, management, and associated factors

Aldekheel,

Shahin

2024

Diabetes mellitus

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BACKGROUND: Diabetes mellitus is a prevalent condition in Saudi Arabia, with approximately 20% of the adult population affected, ranking sixth highest in the world. This disease is associated with both acute and chronic complications. Among these complications, hypoglycemia is particularly dangerous and can occur during diabetes treatment. Individuals diagnosed with type 1 diabetes may experience multiple episodes of asymptomatic or symptomatic hypoglycemia per week.AIM: To assess the frequency of hypoglycemic episodes and identify associated factors among individuals with type 1 diabetes in Unaizah City, Saudi Arabia.MATERIALS AND METHODS: A quantitative, cross-sectional, descriptive research design was employed in April and May of 2023. A convenience sample of 280 type 1 diabetic clients living in the Qassim region of Unaizah City was selected. Participants completed an electronic structured questionnaire that collected information on sociodemographic factors and hypoglycemia-related data. Descriptive statistics and a Chi-square test were used for data analysis, utilizing SPSS version 23. Ethical considerations were strictly adhered to throughout the study.RESULTS: The findings revealed that over two-thirds of the participants (72.1%) reported experiencing hypoglycemic episodes within the past week. Furthermore, more than one-fifth of these individuals attributed the cause of the episodes to high insulin doses (21%). Seeking medical assistance to change medications for hypoglycemia was reported by more than half of the participants (55.4%), while less than half received help from others during hypoglycemic episodes (42.9%). It was observed that adherence to diabetic medication was higher than adherence to diabetic diet and exercise regimens. Males, as well as single or divorced participants, reported a higher frequency of hypoglycemic episodes. Additionally, patients with higher levels of education and those residing in rural regions reported a higher exposure to hypoglycemic episodes.CONCLUSION: The effective management of hypoglycemia necessitates patient education and awareness regarding its causes and symptoms. Targeted interventions are required to improve adherence to therapeutic regimens and lifestyle modifications. Furthermore, when managing hypoglycemia, it is important to consider the gender, marital status, educational level, and residence of diabetic patients.

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Section: Sample Representativitymentioning

confidence: 94%

Section: Sample Representativitymentioning

confidence: 99%

Hypoglycemic episodes among type 1 diabetic patients in Unaizah, Saudi Arabia: causes, management, and associated factors

Aldekheel,

Shahin

2024

Diabetes mellitus

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“…The FLEX study is registered on clinicaltrials.gov, NCT01286350, and a detailed description of the design, 17 main results 18,38 and secondary analyses [39][40][41][42] of the FLEX study have been previously published.…”

Section: Protocolmentioning

confidence: 99%

Pre‐exercise protein intake is associated with reduced time in hypoglycaemia among adolescents with type 1 diabetes

Muntis,

Crandell,

Evenson

et al. 2024

Diabetes Obesity Metabolism

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AimSecondary analyses were conducted from a randomized trial of an adaptive behavioural intervention to assess the relationship between protein intake (g and g/kg) consumed within 4 h before moderate‐to‐vigorous physical activity (MVPA) bouts and glycaemia during and following MVPA bouts among adolescents with type 1 diabetes (T1D).Materials and MethodsAdolescents (n = 112) with T1D, 14.5 (13.8, 15.7) years of age and 36.6% overweight/obese, provided measures of glycaemia using continuous glucose monitoring [percentage of time above range (>180 mg/dl), time in range (70‐180 mg/dl), time below range (TBR; <70 mg/dl)], self‐reported physical activity (previous day physical activity recalls), and 24 h dietary recall data at baseline and 6 months post‐intervention. Mixed effects regression models adjusted for design (randomization assignment, study site), demographic, clinical, anthropometric, dietary, physical activity and timing covariates estimated the association between pre‐exercise protein intake on percentage of time above range, time in range and TBR during and following MVPA.ResultsPre‐exercise protein intakes of 10‐19.9 g and >20 g were associated with an absolute reduction of −4.41% (p = .04) and −4.83% (p = .02) TBR during physical activity compared with those who did not consume protein before MVPA. Similarly, relative protein intakes of 0.125‐0.249 g/kg and ≥0.25 g/kg were associated with −5.38% (p = .01) and −4.32% (p = .03) absolute reductions in TBR during physical activity. We did not observe a significant association between protein intake and measures of glycaemia following bouts of MVPA.ConclusionsAmong adolescents with T1D, a dose of ≥10 g or ≥0.125 g/kg of protein within 4 h before MVPA may promote reduced time in hypoglycaemia during, but not following, physical activity.

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More hypoglycemia not associated with increasing estimated adiposity in youth with type 1 diabetes

Cited by 2 publications

References 44 publications

Hypoglycemic episodes among type 1 diabetic patients in Unaizah, Saudi Arabia: causes, management, and associated factors

Hypoglycemic episodes among type 1 diabetic patients in Unaizah, Saudi Arabia: causes, management, and associated factors

Pre‐exercise protein intake is associated with reduced time in hypoglycaemia among adolescents with type 1 diabetes

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