More highly myelinated white matter tracts are associated with faster processing speed in healthy adults

Chopra, Sidhant; Shaw, Marnie; Shaw, Thomas; Sachdev, Perminder S.; Anstey, Kaarin J.

doi:10.1016/j.neuroimage.2017.12.069

Cited by 58 publications

(25 citation statements)

References 64 publications

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“…Several studies have reported that the corona radiata is stiffer than the corpus callosum (Budday et al, 2017;Johnson et al, 2013), which agrees with our measurements of 3.36 ± 0.33 kPa and 3.05 ± 0.32 kPa, respectively. There is evidence to suggest that the corona radiata possesses more myelin than the corpus callosum (Chopra et al, 2018), and thus myelin content could contribute to the higher stiffness reported (Weickenmeier et al, 2016(Weickenmeier et al, , 2017. Notably, the fornix, which is part of the limbic system and is critically involved in the formation of new memories (Douet & Chang, 2015;Schwarb et al, 2019), is particularly soft and exhibits greatest variability among participants for both MRE measures.…”

Section: Discussionmentioning

confidence: 99%

Standard‐space atlas of the viscoelastic properties of the human brain

Hiscox

McGarry

Schwarb

et al. 2020

Human Brain Mapping

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Standard anatomical atlases are common in neuroimaging because they facilitate data analyses and comparisons across subjects and studies. The purpose of this study was to develop a standardized human brain atlas based on the physical mechanical properties (i.e., tissue viscoelasticity) of brain tissue using magnetic resonance elastography (MRE). MRE is a phase contrast-based MRI method that quantifies tissue viscoelasticity noninvasively and in vivo thus providing a macroscopic representation of the microstructural constituents of soft biological tissue. The development of standardized brain MRE atlases are therefore beneficial for comparing neural tissue integrity across populations. Data from a large number of healthy, young adults from multiple studies collected using common MRE acquisition and analysis protocols were assembled (N = 134; 78F/ 56 M; 18-35 years). Nonlinear image registration methods were applied to normalize viscoelastic property maps (shear stiffness, μ, and damping ratio, ξ) to the MNI152 standard structural template within the spatial coordinates of the ICBM-152. We find that average MRE brain templates contain emerging and

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Section: Discussionmentioning

confidence: 99%

Standard‐space atlas of the viscoelastic properties of the human brain

Hiscox

McGarry

Schwarb

et al. 2020

Human Brain Mapping

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“…Neurite orientation dispersion and density imaging (NODDI) 18 may offer more sensitivity and specificity as it models changes in fiber dispersion (orientation dispersion index [ODI]) as well as density of the tissue microstructure (intracellular volume fraction [ICVF]). NODDI has been successfully applied in studies of typical development 19 , 20 and clinical populations 21 but not yet in SCA.…”

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confidence: 99%

White matter integrity and processing speed in sickle cell anemia

et al. 2018

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ObjectiveThe purpose of this retrospective cross-sectional study was to investigate whether changes in white matter integrity are related to slower processing speed in sickle cell anemia.MethodsThirty-seven patients with silent cerebral infarction, 46 patients with normal MRI, and 32 sibling controls (age range 8–37 years) underwent cognitive assessment using the Wechsler scales and 3-tesla MRI. Tract-based spatial statistics analyses of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters were performed.ResultsProcessing speed index (PSI) was lower in patients than controls by 9.34 points (95% confidence interval: 4.635–14.855, p = 0.0003). Full Scale IQ was lower by 4.14 scaled points (95% confidence interval: −1.066 to 9.551, p = 0.1), but this difference was abolished when PSI was included as a covariate (p = 0.18). There were no differences in cognition between patients with and without silent cerebral infarction, and both groups had lower PSI than controls (both p < 0.001). In patients, arterial oxygen content, socioeconomic status, age, and male sex were identified as predictors of PSI, and correlations were found between PSI and DTI scalars (fractional anisotropy r = 0.614, p < 0.00001; r = −0.457, p < 0.00001; mean diffusivity r = −0.341, p = 0.0016; radial diffusivity r = −0.457, p < 0.00001) and NODDI parameters (intracellular volume fraction r = 0.364, p = 0.0007) in widespread regions.ConclusionOur results extend previous reports of impairment that is independent of presence of infarction and may worsen with age. We identify processing speed as a vulnerable domain, with deficits potentially mediating difficulties across other domains, and provide evidence that reduced processing speed is related to the integrity of normal-appearing white matter using microstructure parameters from DTI and NODDI.

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“…Given the effects of exercise on executive functions and processing speed (Colcombe & Kramer, 2003;Kramer & Colcombe, 2018) and the reliance of processing speed on WM integrity (Chopra et al, 2018), we were surprised to find no associations between change in T1w/T2w and change in these two cognitive domains. Although we observed performance decline trends in the control group for the executive function and processing speed components, these were not statistically significant.…”

Section: Episodic Memory and T1w/t2wmentioning

confidence: 80%

6-month aerobic walking training increases T1w/T2w signal in the white matter of healthy older adults

Colmenares

Voss

Fanning

et al. 2020

Preprint

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White matter (WM) deterioration is an important mechanism of cognitive decline in healthy aging and dementia. Engaging in aerobic exercise to improve cardiorespiratory fitness (CRF) is considered one of the most promising ways to improve cognitive and brain health in aging. Yet, no randomized controlled trials have reported benefits of aerobic exercise interventions on WM microstructure measured with diffusion tensor imaging. Here, we studied the effects of a 6-month exercise intervention (clinical trial NCT01472744) on WM of 180 cognitively healthy older adults (60–79 years) using the ratio of calibrated T1-weighted image to T2-weighted images (T1w/T2w). Participants were randomized to one of four groups including a low intensity activity with complex cognitive demands (Dance), Walking, Walking + nutritional supplement or an active control. Results showed that a 6-month aerobic walking and dance intervention produced positive changes in the T1w/T2w with significant time-by-group interactions in the total WM, the genu and splenium of the corpus callosum, forceps minor, cingulum, relative to an active control condition. In contrast, we observed a decline in T1w/T2w in the majority of WM regions in the active control group. Lastly, a positive change in the T1w/T2w in the genu of the corpus callosum correlated with a positive change in episodic memory in the Walking but not in the control group; however, there were no associations between change in the T1w/T2w and change in CRF. Together, our findings suggest that the T1w/T2w may be a sensitive metric to detect short-term within-person changes in the WM and intervention-induced WM plasticity in the adult human brain.

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More highly myelinated white matter tracts are associated with faster processing speed in healthy adults

Cited by 58 publications

References 64 publications

Standard‐space atlas of the viscoelastic properties of the human brain

Standard‐space atlas of the viscoelastic properties of the human brain

White matter integrity and processing speed in sickle cell anemia

6-month aerobic walking training increases T1w/T2w signal in the white matter of healthy older adults

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