Exposure to lead, a toxic metal, can result in severe effects in children, including decreased ability to learn, permanent neurologic damage, organ failure, and death. CDC and other health care organizations recommend routine blood lead level (BLL) testing among children as part of well-child examinations to facilitate prompt identification of elevated BLL, eliminate source exposure, and provide medical and other services (1). To describe BLL testing trends among young children during the coronavirus disease 2019 (COVID-19) pandemic, CDC analyzed data reported from 34 state and local health departments about BLL testing among children aged <6 years conducted during January-May 2019 and January-May 2020. Compared with testing in 2019, testing during January-May 2020 decreased by 34%, with 480,172 fewer children tested. An estimated 9,603 children with elevated BLL were missed because of decreased BLL testing. Despite geographic variability, all health departments reported fewer children tested for BLL after the national COVID-19 emergency declaration (March-May 2020). In addition, health departments reported difficulty conducting medical follow-up and environmental investigations for children with elevated BLLs because of staffing shortages and constraints on home visits associated with the pandemic. Providers and public health agencies need to take action to ensure that children who missed their scheduled blood lead screening test, or who required follow-up on an earlier high BLL, be tested as soon as possible and receive appropriate care. CDC identifies no safe BLL in children and considers a blood lead reference value (BLRV) of 5.0 µg/dL* sufficient to prompt clinical and public health intervention (1,2). Among children aged <6 years, very high BLL (>70 µg/dL) can cause neurologic problems (e.g., seizures or coma), organ failure, and death. Lower, but still elevated, BLL can affect the nervous system, causing permanent neurologic damage, behavioral disorders, and cognitive impairment (1). In the United States, the most common childhood lead exposures are from lead-based paint * CDC uses a BLRV of 5.0 µg/dL to identify children with blood lead levels that are higher than those of most children. The BLRV is based on the 97.5th percentile of the NHANES blood lead distribution in children aged 1-5 years.