In general, Picard-Fuchs systems in N = 2 supersymmetric Yang-Mills theories are realized as a set of simultaneous partial differential equations. However, if the QCD scale parameter is used as unique independent variable instead of moduli, the resulting Picard-Fuchs systems are represented by a single ordinary differential equation (ODE) whose order coincides with the total number of independent periods. This paper discusses some properties of these Picard-Fuchs ODEs. In contrast with the usual Picard-Fuchs systems written in terms of moduli derivatives, there exists a Wronskian for this ordinary differential system and this Wronskian produces a new relation among periods, moduli and QCD scale parameter, which in the case of SU (2)