More efficient preparation of parenteral emulsions or how to improve a pharmaceutical recipe by formulation engineering

Cuellar, Ingrith; Bullón, Johnny; Forgarini, A.M.; Cárdenas, Antonio; Briceño, María Isabel

doi:10.1016/j.ces.2004.11.013

Cited by 11 publications

(14 citation statements)

References 18 publications

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“…On top of that, the overall goal of this project is under the frame of sustainable chemical engineering insofar as applications of bio‐based chemicals are explored . Also, according to this principle, a specific strategy was followed considering the emulsion formulation and the reduction of energy input in order to obtain fine stable emulsions …”

Section: Introductionmentioning

confidence: 99%

Physical characterization of eco‐friendly O/W emulsions developed through a strategy based on product engineering principles

et al. 2014

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Many traditional industrial products are being gradually replaced by environmental friendly alternatives. N,N-Dimethyldecanamide and D-limonene are solvents that fulfil the requirements to be considered green solvents and may find application in agrochemicals. This contribution deals with the study of emulsions formulated with a mixture of these solvents and an eco-friendly emulsifier. The procedure followed for the development of these formulations was based on the application of product design principles. This led to the optimum homogenization rate and subsequently to the optimum ratio of solvents. The combination of different techniques (rheology, laser diffraction, confocal laser-scanning microscopy, and multiple light scattering) was demonstrated to be a powerful tool to assist in the prediction of the emulsions destabilization process. Thus, we found that the optimum ratio of solvents was 75/25 (N,N-dimethyldecanamide/D-limonene) on account of the lack of coalescence and of a low creaming rate.Standard deviation of the mean (three replicates) for D 2,3 < 5%. Standard deviation of the mean (three replicates) for uniformity < 5%.

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Section: Introductionmentioning

confidence: 99%

Physical characterization of eco‐friendly O/W emulsions developed through a strategy based on product engineering principles

et al. 2014

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“…Rheological studies concerning emulsions have only begun recently and are mostly concerned with “dispersed” emulsions (with an internal volume ratio lower than 0.74), whereas most of HIPR emulsion studies are made on water‐in‐oil (W/O) emulsions 7, 8. HIPR inverse emulsions (O/W), which are considered in this work, generally have a shear thinning behavior with viscosity ranging from a few to several thousand Pa s as a function of the shear rate, the droplet size distribution, and the internal volume ratio 9–11…”

Section: Introductionmentioning

confidence: 99%

A low‐energy emulsification batch mixer for concentrated oil‐in‐water emulsions

et al. 2010

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This work shows the formation of a high internal phase ratio oil-in-water (O/W) emulsion using a new type of a two-rod batch mixer. The mixture components have sharply different viscosities [1/3400 for water-in-oil (W/O)], similar densities (1/0.974 for W/O), and an O/W ratio of 91% (wt/wt). The simple design of this mixer leads to a low-energy process (10 6 \ energy density), characterized by low rotational speed and laminar flow. The droplet size distribution during the emulsification was investigated according to different physical and formulation parameters such as stirring time (few minutes \ t \ 1 h), rotational speed (60 \ X \ 120 rpm), surfactant type (Triton X-405 and X-100), concentration (from 1 to 15.9 wt % in water), and salt addition (30 g/L). We show that all studied parameters allow a precise control of the droplet size distribution and the rheology. The resulting emulsions are unimodal and the mean droplet diameter is between 30 lm and 8 lm.

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“…Numerical formulation expressions have been recently used as a quantitative design tool in an increasing number of micro-and macroemulsion applications such as crude oil dehydration, aluminum lamination, waterborne alkyd of epoxy paint emulsions, pesticide or cutting oil concentrates, environmental remediation, parenteral emulsions, detergency, drilling fluids, or fuel emulsions [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%