More data on in vitro assessment of comparative and combined toxicity of metal oxide nanoparticles

Бушуева, Т. В.; Minigalieva, Ilzira A.; Panov, Vladimir G.; Кузнецова, А. Н.; Naumova, Anna; Shur, V. Ya.; Шишкина, Е. В.; Gurviсh, Vladimir; Privalova, Larisa I.; Katsnelson, Boris A.

doi:10.1016/j.fct.2019.110753

Cited by 15 publications

(13 citation statements)

References 30 publications

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“…The experimental data on the relationship between ATP-dependent luminescence decrease in a culture of cardiomyocytes and CdS-NP dose are of a usual monotonic character, which can be approximated by many functional expressions. As well as in our previous studies, 8,9 in this case, too, we found the most suitable approximation to be a hyperbolic function of the form (2), the parameters of which are fitted by the least squares method. For this end point, expressed as a percentage relative to the control value rather than in absolute AFU, model (2) predicts the kinetics of its decrease shown by the curve in Figure 3.…”

Section: Resultssupporting

confidence: 81%

“…This essential postulate of the theory of combined toxicity was also confirmed in experiments on different cell cultures exposed, alone or in combination, to NPs of manganese and nickel oxides 8 or lead and copper oxides. 9 It should be stressed that the typological ambiguity of the combined toxicity of cadmium and lead in ionic form was shown, in particular, under subchronic intoxication of rats by a large number of end points, including hemodynamic and electrocardiographic ones. 12 We believe that the experimental results considered in this paper are in good agreement with all these previously obtained data and strengthen the theoretical postulate formulated above.…”

Section: Resultsmentioning

confidence: 99%

“…Choosing cytotoxicity indicators. As well as in our previous studies mentioned above, 8,9 we were primarily interested in estimating quantitatively the nonspecific cytotoxicity of the NP species under study for the cells of the line used. Of the various assays that were available for this assessment and, in particular, used by us previously, we opted for the measurement of adenosine triphosphate (ATP)-dependent luminescence in cell culture.…”

Section: Cell Line Characterization In Vitro Exposure Technique and mentioning

confidence: 99%

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Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

et al. 2020

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Spherical nanoparticles (NPs) of cadmium and lead sulfides (diameter 37 ± 5 and 24 ± 4 nm, respectively) have been found to be cytotoxic for HL-1 cardiomyocytes as evidenced by decrease in adenosine triphosphate–dependent luminescence. Cadmium sulfide (CdS)-NPs were discovered to produce a much greater cytotoxic impact than lead sulphide (PbS)-NP. Given the same dose range, CdS-NP reduced the number of calcium spikes. A similar effect was observed for small doses of PbS-NP. In addition to cell hypertrophy under the impact of certain doses of CdS-NP and PbS-NP, doses causing cardiomyocyte size reduction were identified. For these 3 outcomes, we obtained both monotonic “dose–response” functions (well approximated by the hyperbolic function) and different variants of non-monotonic ones for which we found adequate mathematical expressions by modifying certain models of hormesis available in the literature. Data analysis using a response surface linear model with a cross-term provided new support to the previously established postulate that a diversity of types of joint action characteristic of one and the same pair of damaging agents is one of the important assertions of the general theory of combined toxicity.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Cell Line Characterization In Vitro Exposure Technique and mentioning

confidence: 99%

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Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

et al. 2020

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“…There is no doubt that this toxicity is an inherent feature of PbO-NP at all biological levels-from cellular to systemic. It has been shown, in particular, under subchronic intoxication caused in vivo by repeated intraperitoneal injections of PbO nanosuspension to rats [9] and in vitro by its addition to the incubation medium for human fibroblasts [10]. It would be difficult to think of any a priori causes why the inhalation of PbO-NP should not cause lead poisoning.…”

Section: Introductionmentioning

confidence: 99%

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development).

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“…Several studies have investigated the mechanism of toxicity of Ag -NPs suggesting that their cytotoxicity is mainly mediated by induction of reactive oxygen species (ROS). The size of the NPs, their dose and the duration of treatment are critical in mediating their effects [39,40]. Another factor associated with the cytotoxicity of AgNPs is the surface-stabilizing agent [41,42].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model

Docea

Calina

Buga

et al. 2020

IJMS

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This study aimed to evaluate the subacute effect of two types of Ag-NPs(EG-AgNPs and PVP-EG-AgNPs) on antioxidant/pro-oxidant balance in rats. Seventy Wistar rats (35 males and 35 females) were divided in 7 groups and intraperitoneally exposed for 28 days to 0, 1, 2 and 4 mg/kg bw/day EG-Ag-NPs and 1, 2 and 4 mg/kg bw/day PVP- EG-Ag-NPs. After 28 days, the blood was collected, and the total antioxidant capacity (TAC), thiobarbituric reactive species (TBARS),protein carbonyl (PROTC) levels, reduced glutathione (GSH) levels and catalase (CAT) activity were determined. EG-Ag-NPs determined protective antioxidant effects in a dose-dependent manner. The exposure to the 4 mg/kg bw/day EG-Ag-NPs determines both in males and females a significant increase in TAC and CAT and a significant decrease in TBARS and PROTC only in females. The PVP-EG-AgNPs showed a different trend compared to EG-AgNPs. At 4 mg/kg bw/day the PVP-EG-AgNPs induce increased PROTC levels and decreased GSH (males and females) and TAC levels (males). The different mechanisms of EG-AgNPs and PVP-EG-AgNPs on antioxidant-/pro-oxidant balance can be explained by the influence of coating agent used for the preparation of the nanoparticles in the formation and composition of protein corona that influence their pathophysiology in the organism.

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More data on in vitro assessment of comparative and combined toxicity of metal oxide nanoparticles

Cited by 15 publications

References 30 publications

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model

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