More data on epidemiology and outcome of acute kidney injury with AKIN criteria: Benefits of standardized definitions, AKIN and RIFLE classifications*

Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality

“…The CGR is itself dependent on the non-enzymatic hydrolysis of creatine, which is produced primarily in the liver but stored almost entirely in skeletal muscle. Progressive stages of kidney injury in both the RIFLE and AKIN frameworks predict mortality [4][5][6][7][8][9][10], but studies in stable outpatients demonstrate that higher CGR independently associates with better survival [11]. Similar findings have been published in chronic hemodialysis patients [12].…”

Hyperosmolar dehydration: A predictor of kidney injury and outcome in hospitalised older adults

“…Clinically reported dehydration (ICD-10 code E86.X) indicated severe dehydration or dehydration requiring intravenous fluids. AKI was defined using a combination of criteria from Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE) and Acute Kidney Injury Network (AKIN) classifications, widely accepted as the diagnostic benchmark at the time of the data collection [ 15 ]. In effect, the criteria were very similar to the subsequently internationally-adopted KDIGO classification system and the algorithms used have been published RIFLE classifications “risk ”and “injury” were considered equivalent to AKI stage 1 and 2 respectively [ 16 ].…”

Acute Kidney Injury in the Newborn

“…It is increasingly recognized as a common and significant event for newborns cared for in the neonatal intensive care unit, with important implications for treatment decisions and clinical outcomes. Indeed, AKI is associated with mortality in critically ill children [2,87] and adults [14,25,52,66,79], even after controlling for medical comorbidities, severity of illness scores, and patient demographics. Emerging data suggest a similar association in the neonatal population as well [32,47,48], such that kidney injury can no longer be viewed as an incidental finding but rather an important determinant of patient outcomes.…”