2016
DOI: 10.1128/jvi.00621-16
|View full text |Cite
|
Sign up to set email alerts
|

MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus

Abstract: We previously reported that MORC3, a protein associated with promyelocytic leukemia nuclear bodies (PML NBs), is a target of herpes simplex virus 1 (HSV-1) ICP0-mediated degradation (E. Sloan, et al., PLoS Pathog 11:e1005059, 2015, http: //dx.doi.org/10.1371/journal.ppat.1005059). Since it is well known that certain other components of the PML NB complex play an important role during an intrinsic immune response to HSV-1 and are also degraded or inactivated by ICP0, here we further investigate the role of MORC… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
64
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 49 publications
(69 citation statements)
references
References 94 publications
(141 reference statements)
0
64
0
Order By: Relevance
“…Overall, 131 proteins were rescued by application of MG132 within 24 hr of infection, with 46 proteins rescued at 12 hr post infection, the earliest time point studied ( Figure 1 C). Of the 46 proteins, 7 have already been reported to be degraded by HCMV, including HCMV restriction factors Sp100 and MORC3 ( Kim et al., 2011 , Sloan et al., 2016 , Tavalai et al., 2011 ), E3 ubiquitin ligases ANAPC1, 4, and 5 (anaphase promoting complex subunits 1, 4, and 5) and ITCH (itchy E3 ubiquitin protein ligase) ( Figures 1 B and S2 A) (reviewed in Weekes et al., 2014 ). The remaining 39 proteins have not previously been reported to be targeted for proteasomal degradation by HCMV, including HLTF ( Figures 1 D and 1E).…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Overall, 131 proteins were rescued by application of MG132 within 24 hr of infection, with 46 proteins rescued at 12 hr post infection, the earliest time point studied ( Figure 1 C). Of the 46 proteins, 7 have already been reported to be degraded by HCMV, including HCMV restriction factors Sp100 and MORC3 ( Kim et al., 2011 , Sloan et al., 2016 , Tavalai et al., 2011 ), E3 ubiquitin ligases ANAPC1, 4, and 5 (anaphase promoting complex subunits 1, 4, and 5) and ITCH (itchy E3 ubiquitin protein ligase) ( Figures 1 B and S2 A) (reviewed in Weekes et al., 2014 ). The remaining 39 proteins have not previously been reported to be targeted for proteasomal degradation by HCMV, including HLTF ( Figures 1 D and 1E).…”
Section: Resultsmentioning
confidence: 99%
“…The ten members of the US12 gene family act in concert to suppress the expression of cell-surface immune ligands, with many targeted for lysosomal degradation ( Fielding et al., 2017 ). The degradation of intrinsic cellular restriction factors (e.g., Sp100, DAXX, and MORC3) is induced by virion components or viral proteins expressed early in infection and dramatically enhances the efficiency of infection ( Schreiner and Wodrich, 2013 , Sloan et al., 2016 , Tavalai et al., 2011 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…One of the best characterized HCMV RFs is certainly the ND10 complex, formed by the proteins PML, hDaxx, and Sp100 (Zhang and van Drunen Littel-van den Hurk, 2017). In addition to these components, other molecules, such as the nuclear matrix protein microrchidia family CW-type zinc-finger 3 (MORC3/NXP-2), have been shown to associate with the ND10 complex and exert antiviral activity through an unknown mechanism (Sloan et al, 2016).…”
Section: Nd10 Complexmentioning
confidence: 99%
“…Promyelocytic leukaemia nuclear bodies (PML-NBs) is a PML protein-based sub-nuclear structure with an intrinsic anti-viral activity against a wide range of RNA and DNA viruses. More than 150 proteins have been identified either transiently or residentially associated with PML-NBs, many of which possesses an anti-viral activity including Sp100, Daxx, ATRX, HIRA and MORC3 (1-7). As a countermeasure, numerous viruses have evolved strategies to disrupt or degrade PML-NBs underscoring the importance of this structure in cellular anti-viral defense.…”
Section: Introductionmentioning
confidence: 99%