MORC2 Interactome: Its Involvement in Metabolism and Cancer

Guddeti, Rohith Kumar; Chutani, Namita; Pakala, Suresh B.

doi:10.1007/s12551-021-00812-x

Cited by 14 publications

(16 citation statements)

References 54 publications

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“…The next Review, submitted by a team of scientists from India, discusses what is known about the structural and cellular biology of MORC-2, a member of the nuclear protein superfamily found throughout the animal kingdom, which is also highly correlated with cancer development (Guddeti et al 2021). Dovetailing nicely with the previous article, MORC-2 has been shown to be involved with chromatin remodeling, interacting through its DNA-binding zinc finger domain.…”

Section: Precis Of Current Issue Contentsmentioning

confidence: 76%

“…As is typical for a nuclear protein possessing a coiled-coil protein-protein interacting domain, defects in MORC-2 are associated with a range of nucleus-specific functions such as cancer and DNA damage repair. However, less obvious is MORC-2's noted role in transcriptional regulation of glycolysis and lipogenesis (Guddeti et al 2021). As understanding the nature of the basic components of the chemistry of life is an essential prelude to its biophysical modeling, this review article is a welcome addition to the growing collection on the biophysics of cancer that has appeared in the journal.…”

Section: Precis Of Current Issue Contentsmentioning

confidence: 99%

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Biophysical reviews—providing an effective critique

Hall

2021

Biophys Rev

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This Editorial for Volume 13, Issue 4 of Biophysical Reviews begins with an introduction to the invited Review contributed by the 2021 winner of "The Michèle Auger Award for Young Scientists' Independent Research" (Assoc. Prof. Jorge Alegre-Cebollada). After providing a short summary of the other articles contained within the Issue, we discuss some additional matters important to the journal and its readers. In particular, this Editorial describes ongoing preparations for the upcoming IUPAB World Congress (October 4th-8th); it introduces two new Executive Editors from the UK and Spain; it describes the journal's placement in the latest SCIMago journal rankings, and it explains a new feature of the journal-"The Biophysical Reviews Historical Top Five". This piece closes with some thoughts about what might constitute a constructive critique of a manuscript.

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Section: Precis Of Current Issue Contentsmentioning

confidence: 76%

Section: Precis Of Current Issue Contentsmentioning

confidence: 99%

Biophysical reviews—providing an effective critique

Hall

2021

Biophys Rev

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“…MORC2 is an emerging chromatin remodeler and found to be dysregulated in multiple cancers [19,[42][43][44]. MORC2 has a very prominent role in DNA damage response, cancer cell proliferation, invasion, migration, and metastasis [22,[44][45][46][47][48][49].…”

Section: Discussionmentioning

confidence: 99%

MORC2 interaction with MAX contributes to the expression of Glycolytic enzymes, Breast Cancer Cell Proliferation and Migration

Guddeti

Pacharla²,

Yellapu

et al. 2023

Preprint

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Cancer cell proliferation is a high energy demanding process, where the cancer cells acquire the energy by high rates of glycolysis, and this phenomenon is known as the “Warburg effect”. Microrchidia 2 (MORC2), an emerging chromatin remodeler, is over expressed in several cancers including breast cancer, and found to promote cancer cell proliferation. However, the role of MORC2 in glucose metabolism in cancer cells remains unexplored. In this study, we report that MORC2 interacts indirectly with the genes involved in glucose metabolism via transcription factors MAX (MYC-associated factor X) and MYC. We also found that MORC2 colocalizes and interacts with MAX. Further, we observed a positive correlation of expression of MORC2 with glycolytic enzymes Hexokinase 1 (HK1), Lactate dehydrogenase A (LDHA) and Phosphofructokinase platelet type (PFKP) in multiple cancers. Surprisingly, the knockdown of either MORC2 or MAX not only decreased the expression of glycolytic enzymes but also inhibited breast cancer cell proliferation and migration. Together, these results demonstrate the involvement of the MORC2/MAX signaling axis in the expression of glycolytic enzymes and breast cancer cell proliferation and migration.

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“…It is well reported that MORC2 plays an essential role in invasiveness and metastasis in most types of cancers [ 9 , 11 , 12 ]. Studies have shown that MORC2 promotes cell growth and metastasis in human cholangiocarcinoma and is negatively regulated by miR-186-5p [ 18 ], the MORC2-mutant M276I promotes metastasis of triple-negative breast cancer by regulating CD44 splicing [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have reported that MORC2 is upregulated in most cancers including the lung, kidney, breast, liver, etc. [ 9 , 10 ], and the high expression of MORC2 in cancer cells is not only related to tumorigenesis and metastasis [ 8 , 11 ], but also associated with drug resistance in tumor therapy, including radiation, chemotherapy, and endocrine resistance [ 11 , 12 , 13 , 14 ]. Evidence has shown that MORC2 plays an essential role in DNA damage response by recruiting DNA repair proteins to the site of DNA damage through its ATPase dependent chromatin remodeling activity [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis

Long

et al. 2022

Molecules

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(1) Background: Colorectal cancer (CRC) is a common gastrointestinal malignancy, accounting for the second largest gastrointestinal tumor. MORC2, a newly discovered chromatin remodeling protein, plays an important role in the biological processes of various cancers. However, the potential mechanistic role of MORC2 in promoting proliferation of CRC carcinoma remains unclear. (2) Methods: The Cancer Genome Atlas database was analyzed using bioinformatics to obtain gene expression and clinical prognosis data. The cell proliferation was assessed by CCK8 and EdU assays, as well as xenograft. SA-beta-gal staining, Western blot, and ELISA assay were using to assess the cell senescence and potential mechanism. (3) Results: Our data showed that MORC2 expression was elevated in CRC patients. Depletion of MORC2 inhibited cellular proliferation both in vivo and in vitro. Further studies showed that the depletion of MORC2 enhanced p21 and p53 expression through decreasing HDAC4 and increasing pro-inflammatory factors IL-6 and IL-8, thus, promoting cellular senescence. (4) Conclusions: We concluded that increased MORC2 expression in CRC might play a critical role in tumorigenesis by regulating the cellular senescence, in addition, MORC2 could be a novel biomarker for clinical outcomes and prognosis and a treatment target for CRC.

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MORC2 Interactome: Its Involvement in Metabolism and Cancer

Cited by 14 publications

References 54 publications

Biophysical reviews—providing an effective critique

Biophysical reviews—providing an effective critique

MORC2 interaction with MAX contributes to the expression of Glycolytic enzymes, Breast Cancer Cell Proliferation and Migration

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis

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MORC2 Interactome: Its Involvement in Metabolism and Cancer

Cited by 14 publications

References 54 publications

Biophysical reviews—providing an effective critique

Biophysical reviews—providing an effective critique

­­­MORC2 interaction with MAX contributes to the expression of Glycolytic enzymes, Breast Cancer Cell Proliferation and Migration

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis

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MORC2 interaction with MAX contributes to the expression of Glycolytic enzymes, Breast Cancer Cell Proliferation and Migration