Morbus Addison als seltene Ursache für chronisch erhöhte Transaminasen

Abstract

Common causes of chronically elevated serum liver enzymes include fatty liver disease, chronic viral hepatitis, autoimmune hepatitis, or hereditary metabolic disorders. Adrenocortical insufficiency can also cause elevated liver enzymes. Since 1990 only 11 cases have been reported. We here report a 52-year-old man with elevated liver enzymes (1.5 x upper limit of normal) over the past 10 years. Furthermore, hyponatremia and hyperkalemia were noted. He complained of fatigue and low blood pressure over the past few years. At physical examination a dark complexion was noted. After ruling out chronic viral hepatitis, autoimmune disease, metabolic or hereditary disorders, rare causes of elevated liver enzymes were considered. The endocrinological work-up revealed Addison's disease as cause of serum electrolyte disturbance and elevated liver enzymes. The patient was successfully treated with hydrocortisol and fludrocortisol. After one week, liver enzymes, serum electrolytes and arterial blood pressure had normalized. In conclusion, for patients with constantly elevated liver enzymes also rare, extrahepatic diseases have to be considered. Addison's disease is a rare but fully reversible cause for elevated liver enzymes.

Isolated cortisol deficiency: A rare cause of neonatal cholestasis

“…It is noteworthy that the presentation of adrenal insufficiency with cholestasis is limited only to the early infantile period; hepatic manifestations beyond infancy include hypertransaminasemia[24] but not cholestasis. This observation could be attributed to the relative immaturity of the synthetic and excretory functions of bile acid and bilirubin during early infancy.…”

Adrenal Insufficiency as a Cause of Acute Liver Failure: A Case Report

“…The researchers introduced 3 patients with abnormal liver enzymes due to adrenal insufficiency, and, after appropriate treatment of adrenal insufficiency, their liver enzymes became normal. Other reports are related to 1998, 2001, and 2006 and the last report was published in 2011 [4–6, 11]. …”