MorbiNet Study: Hypothyroidism Comorbidity Networks in the Adult General Population

Moratalla-Navarro, Ferrán; López‐Simarro, Flora; Aguado, Alba

doi:10.1210/clinem/dgaa927

Cited by 9 publications

(5 citation statements)

References 61 publications

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“…34,35 This mechanism may also explain the results in three other studies that describe the risk of poor prognosis related to NTIS in response to critical illness or the association between thyroid hormone levels and allcause mortality. 6,7,36 For participants with any known thyroid disease at baseline we identified a 30% increased risk for future 37,38 Even though we adjusted for many comorbid conditions, residual confounding is still possible. 39 A large population-based study found increased risk of infections with hypothyroidism the first year after baseline measurement of thyroid levels.…”

Section: Discussionmentioning

confidence: 91%

“…Even if our timing of thyroid function measures was before sickness, we speculate that the increased BSI risk still could be a result of confounding by concurrent ill health, as we found no evidence of an association between TSH levels and BSI. Confounding by concurrent ill health can arise because chronically ill patients are more likely to be examined for thyroid disease and thus get the thyroid disease diagnosis while having other comorbid conditions that increase BSI risk 37,38 . Even though we adjusted for many comorbid conditions, residual confounding is still possible 39…”

Section: Discussionmentioning

confidence: 99%

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Thyroid function and risk of bloodstream infections: Results from the Norwegian prospective population‐based HUNT Study

Thorkildsen¹,

Mohus

Åsvold

et al. 2021

Clinical Endocrinology

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Objective Previous studies on thyroid function and risk of infection is conflicting and often stem from intensive care cohorts were nonthyroidal illness syndrome (NTIS) may be present. The objective of this study was to identify the risk of bloodstream infections (BSI) and BSI‐related mortality with thyroid‐stimulating hormone (TSH) levels within the reference range in a general population. Design Prospective follow‐up. Participants The HUNT2 (1995‐97) included 34,619 participants with information on TSH levels. Measurements Hazard ratios (HRs) with 95% confidence interval (CI) confirmed BSIs and BSI‐related mortality until 2011. Results During a median follow‐up of 14.5 years, 1179 experienced at least one episode of BSI and 208 died within 30 days after a BSI. TSH levels within the reference range of 0.5–4.5 mU/L were not associated with the risk of first‐time BSI, with an HR of 0.97 (95% CI: 0.90–1.04) per mU/L. Stratified by baseline age < or ≥65 years, TSH was inversely associated with the risk of BSI (HR: 0.88; 95% CI: 0.78–1.00 per mU/L) in the youngest age group only. Persons with any baseline thyroid disease had a 30% risk and the hyperthyroid subgroup a 57%, and hypothyroidism a 20% increased risk of BSI. TSH levels were not clearly associated with BSI mortality, but the HRs were imprecise due to few BSI‐related deaths. Conclusion There was some evidence of a weak inverse association between TSH levels and the risk of BSI in persons below 65 years of age. The increased risk seen in persons with thyroid illness is probably explained by confounding by concurrent ill health.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Thyroid function and risk of bloodstream infections: Results from the Norwegian prospective population‐based HUNT Study

Thorkildsen¹,

Mohus

Åsvold

et al. 2021

Clinical Endocrinology

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“…For example, a comorbidity network for type 2 diabetes mellitus was visualised for pairs of conditions with OR > 1.2 and P-values for OR < 1e-5 [14]. Another study used OR > 1.2 or OR < 0.8 (for positive and negative associations) with P-values < 1e-5 to depict a comorbidity network of hypothyroidism in adults [15]. A comorbidity network for people living in rural Uganda was visualised for pairs of conditions which satis ed the following three conditions: RR > 1, Phi correlation > 0, and false discovery rate < 0.05.…”

Section: Discussionmentioning

confidence: 99%

Choices of measures of association affect the visualisation and composition of the multimorbidity networks

Baneshi,

Dobson,

Mishra

2023

Preprint

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Background: Network analysis, commonly used to describe the patterns of multimorbidity, uses the strength of association between conditions as weight to classify conditions into communities and calculate centrality statistics. Our aim was to examine the robustness of the results to the choice of weight. Methods: Data used on 27 chronic conditions listed on Australian death certificates for women aged 85+. Five statistics were calculated to measure the association between 351 possible pairs: odds ratio (OR), lift, phi correlation, Salton cosine index (SCI), and normalised-joint frequency of pairs (NF). Network analysis was performed on the 10% of pairs with the highest weight according to each definition, the ‘top pairs’. Results: Out of 56 ‘top pairs’ identified, 13 ones were consistent across all statistics. In networks of OR and lift, three of the conditions which did not join communities were among the top five most prevalent conditions. Networks based on phi and NF had one or two conditions not part of any community. For the SCI statistics, all three conditions which did not join communities had prevalence below 3%. Low prevalence conditions were more likely to have high degree in networks of OR and lift but not SCI. Conclusion: Use of different statistics to estimate weights leads to different networks. For exploratory purposes, one may apply alternative weights to identify a large list of pairs for further assessment in independent studies. However, when the aim is to visualise the data in a robust and parsimonious network, only pairs which are selected by multiple statistics should be visualised.

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“…For patients diagnosed with thyroid diseases, quality of life is also affected by the comorbid disorders. In relation to hypothyroidism, comorbid conditions include laryngeal cancer, congenital disorders, thyroid cancer, anemia with vitamin B12 or folic acid de ciency and goiter (40).…”

Section: Quality Of Life In Thyroid Patientsmentioning

confidence: 99%

Quality of life, social support, and adherence in female patients with thyroid disorders

Kollerits¹,

Zsila

Matuszka

2023

Preprint

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Background According to the 2010 European Health Interview Survey, 51% of women in Hungary have a chronic disease, and the overall health status of the Hungarian population is poorer than in other European countries. Thyroid diseases affected more than 650,000 women in 2021 based on a recent report by the Hungarian Central Statistical Office. Despite the high prevalence rates, quality of life in these patients is scarcely researched in Hungary. To fill this gap, this study aims to explore the associations of the quality of life of thyroid patients in Hungary with social support and adherence. Methods A cross-sectional study was conducted via an online questionnaire. Data from 1058 Hungarian women (M = 36.2 years, SD = 10.9, age range: 18–74 years) were analyzed. Participants were divided into four patient groups based on the type of thyroid disorder: hypothyroidism (n = 392; 37.1%), Hashimoto's thyroiditis (n = 588; 55.6%), hyperthyroidism (n = 36; 3.4%), and Graves’ disease (n = 42; 4.0%). Group comparisons, correlations, and mediation models were performed to explore differences between thyroid patients. Results No differences were found between patients with different types of thyroid diseases in quality of life, adherence, and social support. Consistent, weak associations were found between these mental health indicators. Higher perceived social support partially explained the relationship between adherence and life quality in patients with hypothyroidism and Hashimoto’s thyroiditis. Conclusions No substantial differences were found between patients with different types of thyroid disease in mental well-being indicators. These patients are more psychologically vulnerable and need a socially supportive environment to recover, because higher adherence can lead to a better quality of life, and social support can facilitate this process.

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MorbiNet Study: Hypothyroidism Comorbidity Networks in the Adult General Population

Cited by 9 publications

References 61 publications

Thyroid function and risk of bloodstream infections: Results from the Norwegian prospective population‐based HUNT Study

Thyroid function and risk of bloodstream infections: Results from the Norwegian prospective population‐based HUNT Study

Choices of measures of association affect the visualisation and composition of the multimorbidity networks

Quality of life, social support, and adherence in female patients with thyroid disorders

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