Morbidity of Prostatic Biopsy for Different Biopsy Strategies: Is There a Relation to Core Number and Sampling Region?

Paul, R.; Schöler, S.; Randenborgh, H. Van; Kübler, Hubert; Alschibaja, M.; Busch, Raymonde; Härtung, R.

doi:10.1016/j.eururo.2003.12.007

Cited by 39 publications

(29 citation statements)

References 17 publications

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“…10,11 Our results also showed that the number of biopsy punctures influenced the level of pain during the prostate biopsy and confirmed this with the multivariate analysis.…”

supporting

confidence: 76%

Factors influencing pain during transrectal ultrasonography-guided prostate biopsy

Han

Lee

2007

Prostate Cancer Prostatic Dis

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We prospectively investigated the clinical parameters that influenced pain during prostate biopsies. From 12 hospitals 1781 patients were enrolled. The patients completed a visual analogue scale questionnaire for the pain during the procedure. Age, enema preparation, analgesia use and number of biopsy punctures influenced the level of pain during prostate biopsy in univariate linear regression analysis. However, multivariate analysis showed enema preparation, analgesia use and number of biopsy punctures were independent factors associated with the pain during the procedure. Our study confirmed enema preparation before biopsy and the number of biopsy punctures were associated with the pain during prostate biopsy.

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“…10,11 Our results also showed that the number of biopsy punctures influenced the level of pain during the prostate biopsy and confirmed this with the multivariate analysis.…”

supporting

confidence: 76%

Factors influencing pain during transrectal ultrasonography-guided prostate biopsy

Han

Lee

2007

Prostate Cancer Prostatic Dis

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“…[8] Hematuria is the most frequently seen complication following TRUS-guided prostate biopsy.Hematuria with an incidence ranging between 14.4, and 84%, persists for an average of 2.7-5.1 days which can extend up to 20 days. [5,7,[9][10][11][12][13][14][15][16][17][18][19][20][21] As a minor complication, hematuria which is frequently encountered after biopsy, generally lasts briefly without any need for additional treatment However, in 0.25-0.7% of the cases hematuria leading to clot retention and/or requiring transfusion can be seen. [5,13] Hematospermia which is another frequently seen complication has been reported in 5.7, and 89% of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…the literature. [5,7,[10][11][12][13][14][16][17][18][19][20] Another uncertainty concerning infectious complications relates to the impact of pre-biopsy rectal cleansing on infectious complications. Whereas various authors have reported that enema used for rectal cleansing before biopsy decreased, did not change or even increase infectious complication rates.…”

Section: Discussionmentioning

confidence: 99%

Complications of transrectal ultrasound-guided 12-core prostate biopsy: a single center experience with 2049 patients

Efesoy¹,

Bozlu

Çayan

et al. 2013

Turkish Journal of Urology

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Objective: Currently, transrectal ultrasound-guided (TRUS) systematic prostate biopsy is the standard procedure in the diagnosis of prostate cancer. Although TRUS-guided prostate biopsy is a safe method, it is an invasive procedure that is not free from complications. In this prospective study we evaluated the complications of a TRUS-guided 12-core prostate biopsy. Material and methods:The study included 2049 patients undergoing transrectal ultrasound-guided 12-core prostate biopsy used in the diagnosis of prostate cancer. The indications for the prostate biopsy were abnormal digital rectal examination findings and/or an elevated serum total prostate specific antigen (PSA) level (greater than 4 ng/mL). The participants received prophylactic oral ciprofloxacin (500 mg) the night before and the morning of the biopsy, followed by 500 mg orally twice daily for 2 days. To prevent development of voiding disorders, the patients also received oral alpha blockers for 30 days starting the day before the procedure. A Fleet enema was self-administered the night before the procedure for rectal cleansing. The complications were assessed both 10 days and 1 month after the biopsy. Results:The mean age, serum total PSA level and prostate volume of the patients were 65.4±9.6 years, 18.6±22.4 ng/mL and 51.3±22.4 cc, respectively. From these 2.042 biopsies, 596 cases (29.1%) were histopathologically diagnosed as prostate adenocarcinoma. Minor complications, such as hematuria (66.3%), hematospermia (38.8%), rectal bleeding (28.4%), mild to moderate degrees of vasovagal episodes (7.7%), and genitourinary tract infection (6.1%) were noted frequently. Major complications were rare and included urosepsis (0.5%), rectal bleeding requiring intervention (0.3%), acute urinary retention (0.3%), hematuria necessitating transfusion (0.05%), Fournier's gangrene (0.05%), and myocardial infarction (0.05%).Conclusion: TRUS-guided prostate biopsy is safe for diagnosing prostate cancer with few major but frequent minor complications. However, patients should be informed and followed-up after biopsy regarding possible complications.

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“…27 To achieve accurate findings of biopsy samples, increasing the number of biopsy cores has been discussed. 28,29 At present, it is stressed that the use of biopsy findings for clinical management needs careful consideration, since a certain discrepancy in Gleason score between biopsy and whole tumor specimens may occur.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Gleason grade and score between preoperative biopsy and prostatectomy specimens in prostate cancer

et al. 2006

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Aim: Although the histopathological findings obtained from biopsy specimens are important for choosing the appropriate management of prostate cancer, there have been some discrepancies in Gleason grade and consequently, score between biopsy and surgical specimens. A comparison of findings between these two kinds of specimens was performed. Methods: Radical prostatectomy was performed at Asahi General Hospital on 223 cases of T1b-T3 without previous cancer treatment, and the Gleason grade and score of the biopsy and surgical specimens were compared. Results: A 37% coincidence in Gleason score was obtained between biopsy and surgical specimens; coincidence including one digit difference in score was approximately 70%. Upgrading was more than downgrading. Disagreement in secondary grade was greater than that in primary grade. Disagreement in Gleason score was roughly similar among different score items and was not influenced by level of prostate-specific antigen, however, the small volume of the cancer tissues more affected the discrepancy in score. Conclusion:The use of biopsy findings is required to be taken into account regarding the discrepancy.

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Morbidity of Prostatic Biopsy for Different Biopsy Strategies: Is There a Relation to Core Number and Sampling Region?

Cited by 39 publications

References 17 publications

Factors influencing pain during transrectal ultrasonography-guided prostate biopsy

Factors influencing pain during transrectal ultrasonography-guided prostate biopsy

Complications of transrectal ultrasound-guided 12-core prostate biopsy: a single center experience with 2049 patients

Comparison of Gleason grade and score between preoperative biopsy and prostatectomy specimens in prostate cancer

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