Morbidity of patients with analgesic-associated nephropathy on regular dialysis treatment and after renal transplantation

Balle, C.; Schollmeyer, P.

doi:10.1007/bf01648889

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…Seventy studies reported on the frequency of HK , 25 studies reported on the associated mortality [21,22,34,41,44,45,48,68,70,[86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101] in HD patients with CKD or acute renal failure, and nine studies [21,22,34,41,44,45,48,68,70] reported on both frequency of HK and associated mortality.…”

Section: Hk In Patients With Ckd or Acute Renal Failure Receiving Hdmentioning

confidence: 99%

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The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review

et al. 2021

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Background Patients with chronic kidney disease, especially those receiving hemodialysis (HD), are at risk of hyperkalemia (HK). This systematic review aimed to evaluate the prevalence of HK in patients with renal disease receiving HD and collate evidence on the effect of HK and differing HD patterns (i.e., long vs. short inter-dialytic intervals [LIDI and SIDI, respectively] in a thrice weekly schedule) on mortality. Methods Comprehensive searches were conducted across six databases and selected conference proceedings by two independent reviewers up to September 2020. A hundred and two studies reporting frequency of HK, mortality, or cardiovascular (CV) outcomes in adult patients with acute, chronic or end-stage renal disease in receipt of HD were included. Narrative synthesis of results was undertaken with key findings presented in tables and figures. Results Median prevalence of HK in patients with renal disease receiving HD was 21.6% and increased in patients receiving concomitant medications – mainly renin–angiotensin–aldosterone system inhibitors and potassium-sparing diuretics. Associations between elevated potassium levels and increased risk of both all-cause and CV mortality in the HD population were consistent across the included studies. In addition, there was a rise in all-cause and CV mortality on the day following LIDI compared with the day after the two SIDIs in patients on HD. Conclusions Evidence identified in this systematic review indicates a relationship between HK and LIDI with mortality in patients with renal disease receiving HD, emphasizing the need for effective monitoring and management to control potassium levels both in emergency and chronic HD settings.

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Section: Hk In Patients With Ckd or Acute Renal Failure Receiving Hdmentioning

confidence: 99%

“…Studies varied in the outcome measure used to report mortality. Twelve studies [22,87,88,[91][92][93][94][95][96][97][98][99] reported the proportion of patients that died due to HK in the overall HD population ranging from 0-12.5% (follow-up range: 3-66 months, where reported) (Table 3).…”

Section: Mortality In Hd Patients With Hkmentioning

confidence: 99%

The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review

et al. 2021

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High mortality from urothelial carcinoma despite regular tumor screening in patients with analgesic nephropathy after renal transplantation

Kliem¹,

Thon²,

Krautzig³

et al. 1996

Transpl Int

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Patients with end-stage renal failure due to analgesic nephropathy have an increased risk of developing a urothelial carcinoma. To determine the impact of renal transplantation on the frequency of urothelial carcinomas, we analyzed 2072 patients who underwent 2371 renal transplantation between 1968 and 1993, including 78 (3.8%) with clinically proven analgesic nephropathy. Before and after transplantation a regular tumor screening was performed in patients with analgesic nephropathy by urine cytology and abdominal sonography. In 11 of the 78 patients with analgesic nephropathy (14.1%; age 51-66 years, 40-108 months after initiation of dialysis treatment, 5-77 months after transplantation), a urothelial carcinoma of the native urinary tract, especially the kidneys, was diagnosed. Therapy comprised nephroureterectomy (n = 6), transurethral resection (n = 6) and/or cystectomy (n = 2). Seven patients died due to tumor progression 16.3 (4-33) months postoperatively and one patient died due to a perioperative complication. Despite regular tumor screening after transplantation, the diagnosis of a urothelial carcinoma was made very late, leading to a high tumor-related mortality. As a consequence, we suggest that a bilateral nephroureterectomy should be performed prophylactically in patients with proven analgesic nephropathy. In addition, a cystoscopy with lavage cytology testing of the bladder should be performed twice a year.

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Thermolabile hemoglobin formation by 2-cyanaziridine derivatives

et al. 1995

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Morbidity of patients with analgesic-associated nephropathy on regular dialysis treatment and after renal transplantation

Cited by 6 publications

References 21 publications

The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review

The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review

High mortality from urothelial carcinoma despite regular tumor screening in patients with analgesic nephropathy after renal transplantation

Thermolabile hemoglobin formation by 2-cyanaziridine derivatives

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