Morbidity of immediate breast reconstruction (IBR) after mastectomy by a subpectorally placed silicone prosthesis:the adverse effect of radiotherapy

Contant, Caroline M. E.; Geel, A.N. van; Holt, Bronno van der; Griep, C.; Wai, R. Tjong Joe; Wiggers, Th.

doi:10.1053/ejso.1999.0896

Cited by 120 publications

(59 citation statements)

References 41 publications

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“…According to other studies, the main complications are infection and capsular contracture. 11,15 In our series, LD group events represented 54,5% of all complications but only 9,8% required surgical revision. Complications occurred more frequently in the LDI group (44,6%), related to implant complications.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 54%

“…There was no difference between the two cohorts (p=0,23). There were more delayed complications and more surgical revisions in the group RI (27,3%, RR RI vs. others = 6,4 [2,[6][7][8][9][10][11][12][13][14][15]6]; p=0,0005). Considering all complications, TRAM and RI reconstructions required more surgical revisions than LD reconstructions (RR TRAM vs. LD = 2,7 [1,[4][5]3] and RR RI vs. LD = 4,2 [2,[0][1][2][3][4][5][6][7][8]6]; p=0,0006).…”

Section: Resultsmentioning

confidence: 93%

“…The mean follow-up was 8 years (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Five patients were lost to follow-up.…”

Section: Resultsmentioning

confidence: 99%

“…Constant et al published similar results for RI reconstructions. 15 Whilst it is acknowledged that RT is not always comparable when considering doses, timing and patient tolerance, it is accepted that RT increases reconstruction complications. However, it appears that the complication rate may not be related to the timing of RT/surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it is known that the aesthetic evaluation depends upon various scales used and patient satisfaction has been proven to be high with IBR. 1,14,15 There are several arguments in favor of delivering RT before breast reconstruction. First, a M A N U S C R I P T…”

Section: Discussionmentioning

confidence: 99%

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Mastectomy with immediate breast reconstruction after neoadjuvant chemotherapy and radiation therapy. A new option for patients with operable invasive breast cancer. Results of a 20 years single institution study

Monrigal

Dauplat

Gimbergues

et al. 2011

European Journal of Surgical Oncology (EJSO)

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PurposeTo evaluate the feasability of immediate breast reconstruction (IBR) following mastectomy after neoadjuvant chemotherapy (NACT) and radiation therapy (RT) for operable invasive breast cancer (OIBC), in terms of incidence of local complications, locoregional control and survival. Patients and methodsFrom 1990 to 2008, 210 patients were treated by NACT, RT and mastectomy with IBR for OIBC. One hundred and seven patients underwent a latissimus dorsi flap with implant (LDI), 56 patients a transverse rectus abdominis musculocutaneous (TRAM) flap, 25 an autologous latissimus dorsi flap (ALD) and 22, a retropectoral implant (RI) reconstruction. ResultsForty-six (21,9%) early events were recorded: 20 necrosis, 9 surgical site infections and 6 haematomas, requiring further surgery in 23 patients. More necrosis were observed with TRAM flap reconstructions (p=0,000004), requiring more surgical revision than LD reconstructions. Seromas represented 42% of early complications in LD reconstructions. Fifty-five patients presented with late complications (26,2%) with mainly implant complications (capsular contracture, infection, dislocation, deflation) (23,6%), requiring reintervention in 14 cases. There were more delayed surgical revisions in RI reconstructions (p=0,0005). The 5 years overall and disease-free survival rates were respectively 86,7% and 75,6%. Sixty-four patients presented at least one recurrence (30,5%) with 5 local , 9 locoregional and 54 distant relapses. ConclusionThis therapeutic sequence does not seem to increase the IBR morbidity nor alter disease-free and overall survival.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 93%

“…The mean follow-up was 8 years (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Five patients were lost to follow-up.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Mastectomy with immediate breast reconstruction after neoadjuvant chemotherapy and radiation therapy. A new option for patients with operable invasive breast cancer. Results of a 20 years single institution study

Monrigal

Dauplat

Gimbergues

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Breast reconstruction with alloplastic implants

Agha-Mohammadi

Cruz

Hurwitz

2006

Journal of Surgical Oncology

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This article reviews immediate and delayed breast reconstruction with prosthetic implants, and the effect of irradiation therapy. Despite widespread use of breast conserving surgery for early breast cancer, many breast cancer patients still undergo mastectomy. Some of these patients choose breast reconstruction. Over the last 30 years, techniques for breast reconstruction have evolved significantly with new alternative techniques and improved surgical devises. Immediate or delayed breast reconstruction with silicone prosthesis can be an excellent option. Implant reconstruction may be single or two stage procedures. Traditionally, small breasts with minimal ptosis are suited for single-stage reconstruction. Large breasts or inadequate skin require expanders followed by implants. Minimal excision mastectomy and biological spacers are allowing larger breast single stage reconstruction and improved aesthetics for two stage procedures. With recent studies suggesting survival advantage of post-mastectomy irradiation, many candidates for breast reconstruction are receiving radiotherapy, which complicates healing after breast reconstruction.

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Prosthetic breast reconstruction in previously irradiated breasts: A meta‐analysis

Lee

Mun

2015

Journal of Surgical Oncology

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Morbidity of immediate breast reconstruction (IBR) after mastectomy by a subpectorally placed silicone prosthesis:the adverse effect of radiotherapy

Cited by 120 publications

References 41 publications

Mastectomy with immediate breast reconstruction after neoadjuvant chemotherapy and radiation therapy. A new option for patients with operable invasive breast cancer. Results of a 20 years single institution study

Mastectomy with immediate breast reconstruction after neoadjuvant chemotherapy and radiation therapy. A new option for patients with operable invasive breast cancer. Results of a 20 years single institution study

Breast reconstruction with alloplastic implants

Prosthetic breast reconstruction in previously irradiated breasts: A meta‐analysis

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