Morbidity, mortality, and survival in elderly patients undergoing pulmonary metastasectomy for colorectal cancer

Sponholz, Stefan; Schirren, Moritz; Oguzhan, S.; Schirren, J.

doi:10.1007/s00384-018-3136-1

Cited by 19 publications

(30 citation statements)

References 24 publications

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“…Specifically, they observed that patients with no lymph node involvement survived twice as long as those with lymph node involvement (median survival 94 months versus 42 months in patients with positive lymph node involvement). On the other hand, we have also found studies that did not find significant differences, such as those of Sponholz et al (15) and Kumar et al (16). Sponholz studied 54 over-70-year-old who underwent surgery in Germany, and the only factors that reached significance were disease-free interval and anatomic resection (15), while Kumar analysed 71 patients who underwent surgery in India, and concluded that in their series, the only variables with an impact on survival were a history of extra-pulmonary metastasis and local lymph node invasion at the time of the primary tumour surgery (16).…”

Section: Impact Of Thoracic Lymph Node Involvement On Survival Following Lung Metastasectomysupporting

confidence: 58%

“…On the other hand, we have also found studies that did not find significant differences, such as those of Sponholz et al (15) and Kumar et al (16). Sponholz studied 54 over-70-year-old who underwent surgery in Germany, and the only factors that reached significance were disease-free interval and anatomic resection (15), while Kumar analysed 71 patients who underwent surgery in India, and concluded that in their series, the only variables with an impact on survival were a history of extra-pulmonary metastasis and local lymph node invasion at the time of the primary tumour surgery (16). Taking broader view, we found research analysing metastases from kidney cancer (17), which observed a clear tendency towards a poorer survival rates with increasing lymph node stage, with mean survival times of 71.9, 50.7 and 36 months in patients with N0, N1 and N2 disease, respectively (17).…”

Section: Impact Of Thoracic Lymph Node Involvement On Survival Following Lung Metastasectomysupporting

confidence: 58%

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The role of lymphadenectomy during lung metastasectomy

Zabaleta¹,

Aguinagalde²,

López³

et al. 2019

J. Vis. Surg

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Lymph node involvement implies the presence of two routes of dissemination in patients with lung metastasis. For this reason, we assessed its impact on patients undergoing surgery for lung metastasis.In this review, we have sought to summarise the results of studies analysing the presence of thoracic lymph node involvement in patients who have undergone surgery for lung metastasis from different points of view: its impact on survival, the risk factors for developing lymph node metastasis, the attitude of surgeons towards lymphadenectomy in this population, the safety of systematic lymphadenectomy and the impact of systematic lymphadenectomy on survival.

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Section: Impact Of Thoracic Lymph Node Involvement On Survival Following Lung Metastasectomysupporting

confidence: 58%

Section: Impact Of Thoracic Lymph Node Involvement On Survival Following Lung Metastasectomysupporting

confidence: 58%

The role of lymphadenectomy during lung metastasectomy

Zabaleta¹,

Aguinagalde²,

López³

et al. 2019

J. Vis. Surg

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“…In metastases resections for colorectal metastases, minor morbidity, major morbidity, and mortality were 17, 5.8, and 0%, respectively. 9 Other authors demonstrated a comparable morbidity for metastatic surgery. A video-assisted surgery was associated with lower morbidity.…”

Section: Discussionmentioning

confidence: 92%

Metastases of Urothelium Carcinoma: Differential Diagnosis, Resection, and Survival

Oguzhan

Sponholz

Schirren

et al. 2021

Thorac Cardiovasc Surg

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Background Due to its very aggressive nature and low survival chances, the metastasized urothelium carcinoma poses a challenge in regard to therapy. The gold-standard chemotherapy is platinum based. The therapy options are considered controversial, including new systemic therapies. In this respect, surgical therapies, as already established for pulmonary metastases of other tumor entities play an increasingly important role. The consumption of nicotine is a risk factor not only for urothelium carcinoma but also for a pulmonary carcinoma. Thus, we examined the frequency of a second carcinoma in this cohort. Methods We retrospectively examined patients who had a differential diagnosis of pulmonary metastases, as well as those patients who underwent a surgery due to pulmonary metastases of a urothelium carcinoma between 1999 and 2015. Results A total of 139 patients came to our clinic with the differential diagnosis of pulmonary metastases of a urothelium carcinoma. The most common diagnosis was pulmonary carcinoma (53%). Thirty-one patients underwent surgeries due to pulmonary metastases of a urothelium carcinoma. The median survival was 53 months and the 5-year survival was 51%. With the univariate analysis, only the relapse-free interval of more than 10 months was statistically significant (p < 0.001). Conclusion There is a high coincidence of urothelial carcinoma and lung carcinoma. A histological confirmation should be endeavored. Selected patients undergoing a pulmonary metastasis resection have a survival advantage during the multimodal treatment of pulmonary metastasized urothelial carcinomas. For a definitive recommendation, randomized trials including a uniform multimodal therapy regimen and higher numbers of patients are necessary.

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“…Other prerequisites for an operation are low perioperative and postoperative morbidity and mortality rates, which we have already demonstrated for pulmonary metastasectomy with complete systematic lymph node dissection in previous studies. 18,32 However, because of their proximity to the trachea, the esophagus, the thoracic duct, the superior vena cava, and the recurrent laryngeal nerve, ITLNM resection might be associated with a high risk of morbidity, and resection can be challenging. However, with a morbidity rate of 13% and without any mortality, we have now demonstrated that the resection of these metastases is feasible with good perioperative and postoperative results.…”

Section: Commentmentioning

confidence: 99%