Morbidity in alcoholics. Evidence for accelerated development of physical disease in women

Ashley, Mary Jane

doi:10.1001/archinte.137.7.883

Cited by 139 publications

(76 citation statements)

References 27 publications

(3 reference statements)

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“…According to recent reports, proportions of women in patients with alcoholic liver disease are 41%, 27%, and 23% in England (Hodgson and Thomspon 1976; Krasner et al 1977;Morgan and Sherlock 1977), and 10% in Canada (Ashley et al 1977). As compared with these figures the percentage of 5 in the present study is remarkably low.…”

Section: Discussioncontrasting

confidence: 63%

“…Smaller daily consump tion of alcohol (Wilkinson et al 1969;Pequignot et al 1974;Krasner et al 1977) , shorter duration of excessive drinking (Wilkinson et al 1969;Ashley et al 1977) , and younger age (Hallen and Linne 1970) are pointed out. In the present study, however, the daily consumption of alcohol in the women was almost the same as in the men.…”

Section: Discussionmentioning

confidence: 99%

“…Characteristics of the disease in women were pointed out as follows : shorter duration of excessive drinking (Wilkinson et al 1969;Ashley et al 1977), younger age (Hallen and Linne 1970), smaller daily consumption of alcohol (Wilkinson et al 1969;Pequignot et al 1974;Krasner et al 1977), higher incidence of alcoholic hepatitis (Krasner et al 1977;Morgan and Sherlock 1977), and worse prognosis (Phillips and Davidson 1954;Krasner et al 1977). However, some of these differences were not confirmed by other workers (Rankin et al 1970;Morgan and Sherlock 1977).…”

mentioning

confidence: 99%

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Alcoholic Liver Disease in Women

Nakamura

Takezawa

Sato

et al. 1979

Tohoku J. Exp. Med.

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patients with alcoholic liver disease (123 men and 7 women) were admitted.A half of the women had occupations which are related with alcohol consumption and a half were housewives.Daily consumption of alcohol in the women was the same as in the men. Duration of excessive drinking was 11.4 years in the women and 17.1 years in the men, but the difference was not statist ically significant. Though the difference of the incidence of alcoholic hepatitis in the women (57%) and in the men (27%) was not statistically significant, fre quency of ascites was significantly higher in the women (43%) than in the men (7%). Women seem to be more susceptible to severe form of alcoholic liver damage.sex difference in alcoholic liver disease; alcoholic hepatitis

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Alcoholic Liver Disease in Women

Nakamura

Takezawa

Sato

et al. 1979

Tohoku J. Exp. Med.

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“…Several clinical studies have found sex differences in the expression of EW behaviors and ethanol-induced diseases that have important ramifications for treatment (Ashley et al, 1977;Brown et al, 1988;Schenker, 1997;Deshmukh et al, 2003). These differences support a growing body of evidence showing that males and females have significant differences in inherent neurobiology expressed as varying risks for a number of neuronal-based diseases and responses to stressors, including alcohol (Brathen et al, 1999;Blanchard et al, 2001;Figueiredo et al, 2002;Webb et al, 2002).…”

mentioning

confidence: 91%

Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats

Alele

Devaud²

2006

J Pharmacol Exp Ther

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We investigated the actions of the neuroactive steroid, pregnanolone, and the ovarian steroid, 17␤-estradiol, on seizure expression during two time points of ethanol withdrawal (EW). Both steroids can exert rapid, nongenomic actions on the brain that include modulation of seizure activity. Because their basal levels differ in adult males and females and a major symptom of EW is increased seizure risk, we wanted to determine whether these steroids were anticonvulsant during EW. Rats were made ethanol-dependent by administration of 6% ethanol in a nutritionally complete liquid diet for 14 days. After removal of the ethanol-containing diet, EW and paired control rats were tested at 1 or 3 days for seizure responses to pentylenetetrazol. Consistent with previous reports, females seemed to have recovered from EW more quickly than males. We observed significant sex differences in responses to the steroids, primarily at 3 days EW. Pregnanolone afforded protection against seizures with larger effects during EW than in control conditions and greater effects in female than male rats. In contrast, effects of estradiol were mixed. Some responses of ovariectomized female rats were similar to intact females, whereas other responses were more similar to males. Our behavioral findings are consistent with observed EW-induced changes in plasma corticosterone levels, showing persistent elevations in male but not female rats. These results support and extend earlier findings suggesting that although the hormonal milieu influences EW, innate differences in brain structure between the sexes also contribute to sex differences in EW.Ethanol dependence develops from prolonged intake, is often disruptive to the social, occupational, and physical well being of the individual, and poses significant health and economic burdens. Withdrawal-induced seizures are a significant consequence of ethanol dependence and include risk of injury, even death. Treatment of ethanol withdrawal (EW) remains problematic because of the reduced effectiveness of anticonvulsant drugs due to cross-tolerance with ethanol. The distress and dysphoria of ethanol EW, including enhanced seizure risk, probably contribute to the high risk for relapse.Several clinical studies have found sex differences in the expression of EW behaviors and ethanol-induced diseases that have important ramifications for treatment (Ashley et al., 1977;Brown et al., 1988;Schenker, 1997;Deshmukh et al., 2003). These differences support a growing body of evidence showing that males and females have significant differences in inherent neurobiology expressed as varying risks for a number of neuronal-based diseases and responses to stressors, including alcohol (Brathen et al

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“…1,2 In addition, sex-related differences have also been found in alcoholic fatty liver disease, non-alcoholic steatohepatitis (NASH), and other kinds of chronic hepatitis. [7][8][9] Nonetheless, the mechanisms that account for this gender disparity are unknown. With increasing reports of occurrence of NASH, there is an urgent need to study the molecular mechanism underlying sex-specific differences in disease manifestation and pathology.…”

Section: Introductionmentioning

confidence: 99%

Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway

Xin

Qin

Wang

et al. 2015

Exp Biol Med (Maywood)

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Recent research has shown that the occurrence of gender disparity in liver cancer associated with sex differences in MyD88-dependent IL-6 production, but the role of this signaling pathway in sex differences of non-alcoholic steatohepatitis (NASH) remains unknown. To investigate the effects of sex hormone-specific intervention on pathology and progression of NASH, and on the inflammatory TLR-MyD88-IL-6 signaling pathway NASH was modeled in C57/BL6 mice by feeding a methionine and choline-deficient (MCD) diet for 4 weeks. Male mice were subjected to sex hormone-related interventions such as orchidectomy, and orchidectomy combined with administration of either testosterone propionate or estradiol benzoate. Next, the degree of nonalcoholic fatty liver disease activity score (NAS), serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and the expression level of MyD88 and IL-6, were compared between these groups. Males developed more serious inflammatory problems and had a higher NAS than the females. Sex-specific intervention in male mice by orchidectomy reduced NAS, ALT, and AST, and the expression level of MyD88 and IL-6. But administration of exogenous androgen had no influence on either NAS or the expression of ALT, AST, MyD88, and IL-6. On the other hand, exogenous estrogen could alleviate the pathological damage caused by NASH, as well as reduce NAS, ALT and AST, and the expression of MyD88 and IL-6. The result show different sex hormone-related interventions affected the severity of NASH, possibly by modulating the level of sex hormones and regulating the TLR-MyD88-IL-6 signaling pathway.

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Morbidity in alcoholics. Evidence for accelerated development of physical disease in women

Cited by 139 publications

References 27 publications

Alcoholic Liver Disease in Women

Alcoholic Liver Disease in Women

Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats

Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway

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