Morbidity From Anterior Iliac Crest Bone Harvesting for Secondary Alveolar Bone Grafting: An Outcome Assessment Study

Baqain, Zaid H.; Anabtawi, Mohammed; Karaky, Ashraf Abu; Malkawi, Ziad

doi:10.1016/j.joms.2008.09.023

Cited by 94 publications

(63 citation statements)

References 19 publications

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“…Baqain et al (2009) report neurapraxia of the lateral femoral cutaneous nerve in 8% (2 out of 24) of their patients, while Grossman et al (2001) described the clinical syndrome of ''meralgia paraesthetica'', likely to occur after iatrogenic damage to this nerve during procedures such as anterior iliac crest bone harvesting. Bents (2002) has also reported a case of ilioinguinal neuralgia after anterior iliac crest bone harvesting.…”

Section: Discussionmentioning

confidence: 99%

“…Although conspicuous scarring is considered one of the minor side effects of bone graft harvesting from the anterior iliac crest, the aesthetic appearance of the donor site has been sporadically evaluated in the literature (Laurie et al, 1984;Cohen et al, 1991;Eufinger and Leppänen, 2000;Swan and Goodacre, 2006;Rawashdeh, 2008;Baqain et al, 2009). In our series of patients no keloids were noted and only two hypertrophic scars occurred.…”

Section: Discussionmentioning

confidence: 99%

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Iliac crest morbidity following maxillofacial bone grafting in children: A clinical and radiographic prospective study

Kolomvos

Iatrou

Theologie-Lygidakis

et al. 2010

Journal of Cranio-Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Iliac crest morbidity following maxillofacial bone grafting in children: A clinical and radiographic prospective study

Kolomvos

Iatrou

Theologie-Lygidakis

et al. 2010

Journal of Cranio-Maxillofacial Surgery

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“…1 Although autologous bone grafts have been considered the gold standard for craniofacial reconstruction, they are limited by availability and donor site morbidity and variations in their osteogenic potential. 2,3 Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor that has been extensively used for the treatment of many bone fractures and bone defects. 4 However, supra-physiological milligram-level doses of BMP-2 are required for effective bone repair in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Delivery of Phenamil Enhances BMP-2-Induced Osteogenic Differentiation of Adipose-Derived Stem Cells and Bone Formation in Calvarial Defects

Fan

Cui

et al. 2015

Tissue Engineering Part A

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Bone morphogenetic proteins (BMPs) have been widely used for bone repair in the craniofacial region. However, its high dose requirement in clinical applications revealed adverse effects and inefficient bone formation, along with high cost. Here, we report a novel osteoinductive strategy to effectively complement the osteogenic activity of BMP-2 using phenamil, a small molecule that can induce osteogenic differentiation via stimulation of BMP signaling. Treatment of adipose-derived stem cells (ASCs) with BMP-2 in combination with phenamil significantly promoted the in vitro osteogenic differentiation of ASCs. The efficacy of the combination strategy of phenamil + BMP-2 was further confirmed in a mouse calvarial defect model using scaffolds consisting of poly(lactic-co-glycolic acid) and apatite layer on their surfaces designed to slowly release phenamil and BMP-2. Six weeks after implantation, the scaffolds treated with phenamil + BMP-2 significantly promoted mouse calvarial regeneration as demonstrated by micro-computerized tomography and histology, compared with the groups treated with phenamil or BMP-2 alone. Moreover, the combination treatment reduced the BMP-2 dose without compromising calvarial healing efficacy. These results suggest promising complementary therapeutic strategies for bone repair in more efficient and cost-effective manners.

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“…(Ersoy, 2015) There are many treatment protocols for alveolar cleft, and alveolar bone grafting constitutes the basis of these treatment protocols. (Baqain, Anabtawi, Karaky, & Malkawi, 2009) In addition to clinical evaluations, especially radiological assessments are needed in order to objectively evaluate the postoperative newly formed bone after alveolar bone grafting. Conventional or 3D radiological methods can be used for this purpose.…”

Section: Alveolar Cleft Iliac Bone Graft Gender Discussionmentioning

confidence: 99%

The Evaluation of Gender Effect in Treatment of Alveolar Cleft with Iliac Bone Graft By Means of Volumetric Analysis

Saruhan¹,

Ertaş

2017

Middle Black Sea Journal of Health Science

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Objective: The purpose of this study was to evaluate of gender effect in treatment of alveolar cleft with iliac bone graft by means of volumetric analysis. Methods: In this study; 22 patients with alveolar cleft including 13 unilateral, and 9 bilateral were treated with anterior iliac crest bone graft. Patients were divided into subgroups according to their gender. Cone Beam Computed Tomography scans were obtained preoperatively and postoperatively. 3D reconstruction of Cone Beam Computed Tomography images was made by using Mimics software. Preoperative alveolar cleft volume and postoperative newly formed bone volume was assessed volumetrically. Results and Conclusion: The percentage of preoperative alveolar cleft volume in female ranged from 0.51 to 1.45 cm3 with a mean volume of 0.89±0.27 cm3, in male ranged from 0.72 to 2.04 cm3 with a mean volume of 1.11±0.36 cm3. The percentage of newly formed bone in female ranged from 47.02% to 80.09% with a mean percentage of %68.23±%9.43, in male ranged from 50.70% to 77.49% with a mean percentage of 63.09%±10.72%. There is no statistically significant difference between the female and male for postoperative newly formed bone in treatment of alveolar cleft with iliac bone graft (p>0.05).

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Morbidity From Anterior Iliac Crest Bone Harvesting for Secondary Alveolar Bone Grafting: An Outcome Assessment Study

Cited by 94 publications

References 19 publications

Iliac crest morbidity following maxillofacial bone grafting in children: A clinical and radiographic prospective study

Iliac crest morbidity following maxillofacial bone grafting in children: A clinical and radiographic prospective study

Delivery of Phenamil Enhances BMP-2-Induced Osteogenic Differentiation of Adipose-Derived Stem Cells and Bone Formation in Calvarial Defects

The Evaluation of Gender Effect in Treatment of Alveolar Cleft with Iliac Bone Graft By Means of Volumetric Analysis

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