Morbidity at the iliac crest donor site following bone grafting of the cleft alveolus

Swan, Marc C.; Goodacre, Tim

doi:10.1016/j.bjoms.2005.04.015

Cited by 155 publications

(113 citation statements)

References 14 publications

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“…Ethical committee approval was taken from the institute and after obtaining informed consent from the patients, the post-operative complications were assessed periodically, according to the questionnaire given by Swan et al, [9] which was administered in the local language [Table/ Fig-1]. The study was blinded to the observer who evaluated the patients and was unaware of the outcome of the study.…”

Section: Methodsmentioning

confidence: 99%

Donor Site Evaluation: Anterior Iliac Crest Following Secondary Alveolar Bone Grafting

Vura

Reddy

2013

JCDR

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Section: Methodsmentioning

confidence: 99%

Donor Site Evaluation: Anterior Iliac Crest Following Secondary Alveolar Bone Grafting

Vura

Reddy

2013

JCDR

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“…Bone grafting, as a common form of bone treatment, is done by transferring bone tissue from the donor site to the fractured site before adequate physiological treatment facilitates bone healing. For autologous bone treatment, the bone tissues are usually transferred from the iliac crest of the patient's pelvis (Swan and Goodarce, 2006). While the advantages of autologous bone treatment may include easy access of donor site without requiring the reposition of the patient as well as very low risks of infectious diseases, post-operation complications have been reported to be as high as 15% (Mischkowski et al, 2006;Swan and Goodarce, 2006).…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional fibrous PLGA/HAp composite scaffold for BMP‐2 delivery

Nie

Soh

et al. 2007

Biotech & Bioengineering

194

128

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A protein loaded three-dimensional scaffold can be used for protein delivery and bone tissue regeneration. The main objective of this project was to develop recombinant human bone morphogenetic protein-2 (rhBMP-2) loaded poly(D,L-lactide-co-glycolide)/hydroxylapatite (PLGA/HAp) composite fibrous scaffolds through a promising fabrication technique, electrospinning. In vitro release of BMP-2 from these scaffolds, and the attachment ability and viability of marrow derived messenchymal stem cells (MSCs) in the presence of the scaffolds were investigated. The PLGA/HAp composite scaffolds developed in this study exhibit good morphology and it was observed that HAp nanoparticles were homogeneously dispersed inside PLGA matrix within the scaffold. The composite scaffolds allowed sustained (2-8 weeks) release of BMP-2 whose release rate was accelerated with increasing HAp content. It was also shown that BMP-2 protein successfully maintained its integrity and natural conformations after undergoing the process of electrospinning. Cell culture experiments showed that the encapsulation of HAp could enhance cell attachment to scaffolds and lower cytotoxicity.

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“…5 Procedures involving the application of bone grafts harvested from the iliac crest reportedly lead to adverse complications in 10%-35% of cases. 6,7 Another widely used treatment includes the implantation of metal cages containing recombinant bone morphogenetic protein-2 (BMP-2). Highdose recombinant human BMP-2 (rhBMP2) has been found to cause pseudarthroses, 8,9 various infections, 10 ectopic bone formation that cause neural compression, 11 and abdominal bone growth.…”

Section: Introductionmentioning

confidence: 99%

Genetically Modified Mesenchymal Stem Cells Induce Mechanically Stable Posterior Spine Fusion

Sheyn

Rüthemann

Mizrahi

et al. 2010

Tissue Engineering Part A

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Most spine fusion procedures involve the use of prosthetic fixation devices combined with autologous bone grafts rather than biological treatment. We had shown that spine fusion could be achieved by injection of bone morphogenetic protein-2 (BMP-2)-expressing mesenchymal stem cells (MSCs) into the paraspinal muscle. In this study, we hypothesized that posterior spinal fusion achieved using genetically modified MSCs would be mechanically comparable to that realized using a mechanical fixation. BMP-2-expressing MSCs were injected bilaterally into paravertebral muscles of the mouse lumbar spine. In one control group BMP-2 expression was inhibited. Microcomputed tomography and histological analyses were used to evaluate bone formation. For comparison, a group of mouse spines were bilaterally fused with stainless steel pins. The harvested spines were later tested using a custom four-point bending apparatus and structural bending stiffness was estimated. To assess the degree to which MSC vertebral fusion was targeted and to quantify the effects of fusion on adjacent spinal segments, images of the loaded spine curvature were analyzed to extract rigidity of the individual spinal segments. Bone bridging of the targeted vertebrae was observed in the BMP-2-expressing MSC group, whereas no bone formation was noted in any control group. The biomechanical tests showed that MSC-mediated spinal fusion was as effective as stainless steel pin-based fusion and significantly more rigid than the control groups. Local analysis showed that the distribution of stiffness in the MSC-based fusion group was similar to that in the steel pin fusion group, with the majority of spinal stiffness contributed by the targeted fusion at L3-L5. Our findings demonstrate that MSC-induced spinal fusion can convey biomechanical rigidity to a targeted segment that is comparable to that achieved using an instrumental fixation.

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Morbidity at the iliac crest donor site following bone grafting of the cleft alveolus

Cited by 155 publications

References 14 publications

Donor Site Evaluation: Anterior Iliac Crest Following Secondary Alveolar Bone Grafting

Donor Site Evaluation: Anterior Iliac Crest Following Secondary Alveolar Bone Grafting

Three‐dimensional fibrous PLGA/HAp composite scaffold for BMP‐2 delivery

Genetically Modified Mesenchymal Stem Cells Induce Mechanically Stable Posterior Spine Fusion

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