Morbidity Associated with Schistosoma Mansoni Infection as Determined by Ultrasound: A Study in Gezira, Sudan

Homeida, M; Ahmed, Samia A.; Dafalla, A.A.; Suliman, Salwa; Eltom, I; Nash, Theodore E.; Bennett, J.L.

doi:10.4269/ajtmh.1988.39.196

Cited by 112 publications

(90 citation statements)

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“…This means that these patients with severe schistosomiasis have not been included in previous studies of morbidity in field-based studies on schistosomiasis. A similar observation has been made before in Sudan (Homeida et al 1988). The development of spontaneous shunts may well explain some cases of portal hypertension without an enlarged spleen.…”

Section: Discussionsupporting

confidence: 68%

Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition

Lambertucci

Cota

Pinto-Silva

et al. 2001

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 68%

Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition

Lambertucci

Cota

Pinto-Silva

et al. 2001

Mem. Inst. Oswaldo Cruz

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“…Other studies using MR contained case reports or series of cases and they did not include liver biopsy to confirm the diagnosis and intensity of Symmers' fibrosis. However, using US, Homeida et al (1988b) found results comparable to ours: the diagnosis of LF by US coincided with histology, but they presented poor agreement on fibrosis intensity.…”

Section: Discussionsupporting

confidence: 57%

Imaging techniques and histology in the evaluation of liver fibrosis in hepatosplenic schistosomiasis mansoni in Brazil: a comparative study

Voieta

Queiroz

Andrade

et al. 2010

Mem. Inst. Oswaldo Cruz

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Few publications have compared ultrasound (US) to histology in diagnosing schistosomiasis-induced liver fibrosis (LF); none has used magnetic resonance (MR). The aim of this study was to evaluate schistosomal LF using these three methods. Fourteen patients with hepatosplenic schistosomiasis admitted to hospital for surgical treatment of variceal bleeding were investigated. They were submitted to upper digestive endoscopy, US, MR and wedge liver biopsy. The World Health Organization protocol for US in schistosomiasis was used. Hepatic fibrosis was classified as absent, slight, moderate or intense. Histology and MR confirmed Symmers' fibrosis in all cases. US failed to detect it in one patient. Moderate agreement was found comparing US to MR; poor agreement was found when US or MR were compared to histology. Re-classifying LF as only slight or intense created moderate agreement between imaging techniques and histology. Histomorphometry did not separate slight from intense LF. Two patients with advanced hepatosplenic schistosomiasis presented slight LF. Our data suggest that the presence of the characteristic periportal fibrosis, diagnosed by US, MR or histology, associated with a sign of portal hypertension, defines the severity of the disease. We conclude that imaging techniques are reliable to define the presence of LF but fail in grading its intensity

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“…The suggestion by Egyptian researchers 35 that immunoglobulin A plays an important role in the aggravation of renal lesion in schistosomiasis, mediated by IL-6 and IL-10, was not confirmed in here. Serum levels of IgA were within normal range in all patients.…”

Section: Discussioncontrasting

confidence: 50%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. Methods: Sixty three patients (mean age 45.5±11 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosis of hepatosplenic schistosomiasis was based on epidemiological, clinical and parasitological data and imaging techniques. Eight patients, who presented >30mg/day albuminuria, were submitted to percutaneous ultrasound guided renal biopsy. Kidney tissue fragments were examined under light, direct immunofluorescence and electron microscopy. Results: All patients showed mesangial enlargement. In five, mesangial hypercellularity was observed and four presented duplication of the glomerular basement membrane. Areas of glomerular sclerosis were diagnosed in four. Deposits of immunoglobulin M and C3 were present in six samples; deposits of IgG in four, IgA in three and C1q in two samples. In all patients, immunoglobulin A was reported in the lumen of renal tubules. Deposits of kappa and lambda were observed in six samples. Electron microscopy revealed dense deposits in the glomerular tissue of three patients. Arterial hypertension, small esophageal varices, slight increases in serum creatinine and decreases in serum albumin were associated with glomerular disease. Conclusions: Renal disease associated with hepatosplenic schistosomiasis was verified in 12.7% of patients and type I membranoproliferative glomerulonephritis was observed in 50% of them. Schistosomal glomerulopathy still is an important problem in patients with hepatosplenic schistosomiasis in Brazil.

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Morbidity Associated with Schistosoma Mansoni Infection as Determined by Ultrasound: A Study in Gezira, Sudan

Cited by 112 publications

References 0 publications

Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition

Hepatosplenic schistosomiasis in field-based studies: a combined clinical and sonographic definition

Imaging techniques and histology in the evaluation of liver fibrosis in hepatosplenic schistosomiasis mansoni in Brazil: a comparative study

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

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