Morbidity and Mortality of Unintentional Carbon Monoxide Poisoning: United States 2005 to 2018

Shin, Mikyong; Bronstein, Alvin C.; Glidden, Emily; Malone, Mackenzie; Chang, Arthur; Law, Royal; Boehmer, Tegan K.; Strosnider, Heather; Yip, Fuyuen

doi:10.1016/j.annemergmed.2022.10.011

Cited by 12 publications

(11 citation statements)

References 19 publications

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“…In laboratory tests, the median COHb level in blood gas analysis was 10.1% (IQR, 4.6-19.5). The median COHb level in multiwave pulse oximetry was 11% (IQR, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The median Troponin I level was 0.01 ng/mdL (IQR, 1-3.1).…”

Section: Resultsmentioning

confidence: 99%

“…Analysis of aggregated national data from the United States supports an overall mortality of 1 to 3 percent, with a mortality rate that is higher for intentional poisoning than for inadvertent exposure [11]. There are approximately 1000 to 1300 deaths from CO poisoning annually [8,10].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast with intentional poisoning, unintended poisoning demonstrates both seasonal and regional variation, and occurs more frequently during the winter months in cold climates, most commonly from faulty furnaces [9]. CO is a leading cause of poisoning and is associated with high morbidity and mortality rates [10][11][12]. Data from the United States show approximately 20,000 exposure cases and 439 deaths each year, with a particular focus on unintentional exposure and non-fire-related incidents due to CO poisoning [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry

Yu,

Lee,

Cho

et al. 2024

JPM

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Carbon monoxide (CO) poisoning is difficult to diagnose owing to its nonspecific symptoms. Multiwave pulse oximetry can be used to quickly screen patients for CO poisoning. However, few studies have analyzed patients with CO poisoning who presented to the emergency department (ED). The primary aim of our study was to determine the correlation between COHb levels measured in blood gas analysis and COHb levels measured in multiwave pulse oximetry. Secondary aims were the sensitivity and specificity of the COHb level cutoff value using multiwave pulse oximetry to predict a 25% COHb level in blood gas analysis. This single-center retrospective observational study included patients with CO poisoning who visited the ED of a university-affiliated hospital in Seoul, Korea between July 2021 and June 2023. COHb poisoning was determined using blood gas analysis and multiwave pulse oximetry. The correlation of COHb levels between the two tests was evaluated using correlation analysis. The area under the receiver operating characteristic curve (AUC) of multiwave pulse oximetry was calculated to predict COHb levels from the blood gas analysis. The optimal cutoff values, sensitivity, and specificity of COHb were determined. A total of 224 patients who had COHb levels measured using both multiwave pulse oximetry and blood gas analysis were included in the analysis. In the correlation analysis, COHb showed a high positive correlation with COHb measured using blood gas analysis (Spearman correlation coefficient = 0.86, p < 0.001). The AUC of COHb measured by multiwave pulse oximetry to predict 25% of the COHb level (which can be an indication of hyperbaric oxygen treatment) measured by blood gas analysis was 0.916. When the COHb levels measured with multiwave pulse oximetry were 20% the sensitivity was 81% and the specificity was 83%, and when the COHb levels were 25% the sensitivity was 50% and the specificity was 95%. The COHb value measured using multiwave pulse oximetry blood gas analysis showed a high correlation. However, additional research using large-scale studies is required for validation.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry

Yu,

Lee,

Cho

et al. 2024

JPM

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“…CO is usually produced from the partial combustion of fuel and is classified as one of the most toxic gases. 170 The chemical transformation of CO is based on the gas-phase CO oxidation.…”

Section: Carbon Monoxidementioning

confidence: 99%

MOF-based catalysts: insights into the chemical transformation of greenhouse and toxic gases

Obeso

Flores

et al. 2023

Chem. Commun.

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“…Carbon monoxide (CO) is an odorless, colorless, tasteless, and non-irritating toxic gas, which is primarily produced due to the incomplete combustion of organic compounds. CO poisoning is estimated to occur in 50000 people annually in the United States and the vast majority are non-fire-related smoke inhalation with annual deaths incidence between 1000 and 1300 people per year [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Cardiomyopathy and Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report

Alarbi,

Baghi,

Varikkodan

et al. 2023

Cureus

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Carbon monoxide (CO) is an odorless and colorless gas that is formed by the combustion of hydrocarbon. CO poisoning is not an uncommon phenomenon that can have serious consequences for morbidity and mortality. The most frequent causes of accidental poisoning include smoke inhalation from fires, malfunctioning heating devices, smoke from motor vehicles in a poorly ventilated or enclosed space, and electrical cable fires. CO has a higher affinity to hemoglobin than oxygen leading to the formation of carboxyhemoglobin. It impairs the oxygen transport and cytochrome chain which, therefore, leads to further cellular and immunological changes. Here, we present a case of CO poisoning resulting in combined cardiac and neuropsychiatric complications.

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Morbidity and Mortality of Unintentional Carbon Monoxide Poisoning: United States 2005 to 2018

Cited by 12 publications

References 19 publications

Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry

Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry

MOF-based catalysts: insights into the chemical transformation of greenhouse and toxic gases

Acute Cardiomyopathy and Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report

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