Morbidity and mortality of pneumonia in adults in six Latin American countries

Buzzo, Alfonso Rosado; Roberts, C.S.; Mollinedo, Lourdes García; Quevedo, Joaquin Mould; Casas, Gerardo Luna; Soldevilla, José Manuel Sobrino

doi:10.1016/j.ijid.2013.02.006

Cited by 35 publications

(38 citation statements)

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“…Our results showed a sex gap, with men presenting higher numbers of CAP hospitalizations, mortality and a higher risk of death during hospitalization. These results are in accordance with other studies that show a sex inequality in health indicators associated with hospitalizations [3,4,12,29], with men presenting consistently higher hospitalization rates for CAP, which may be related to a great number of risk factors, such as smoking, alcoholism, and exposure to toxic occupational exposure [3,29]. The greater ratio of male to female mortality may also reflect higher rates of smoking in males predisposing to respiratory disease [3,16].…”

Section: Discussionsupporting

confidence: 90%

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Factors associated with in-hospital mortality from community-acquired pneumonia in Portugal: 2000–2014

et al. 2020

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Background: Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality worldwide, often leading to hospital admissions. In Portugal, the factors associated with in-hospital mortality due to CAP are not fully documented. The aim of this study was to characterize the trends of CAP hospitalization in all age groups and the factors associated with their mortality between 2000 and 2014. Methods: We conducted a cross-sectional study using CAP hospitalization data in all age groups, in Portugal Mainland. Logistic regression was used to identify the factors associated with in-hospital mortality. Results: Between 2001 and 2011, CAP hospitalization rate increased from 2.8 to 4.3 per 1000 population. Hospitalization rates were higher in the extreme ages (≤ 4 and ≥ 75 years). However, a decrease in the hospitalization rate and its mortality was observed, in the younger ages. A total of 548,699 hospitalization CAP episodes, between 2000 and 2014, were analyzed, with male (56.2%) and elderly ≥65 years (91.7%) predominance, resulting in 101,740 deaths (18.5%). Men had a significantly lower mean age (64.3 ± 26.4 years versus 67.9 ± 27.5 years; p < 0.001). During the studied 15 years, there was an increase of 45.2% in the number of annual hospitalizations, concomitant with the admission increase of individuals aged over 75 years. Since 2012 a decrease in hospitalizations and associated deaths were detected. The increase in age represented a progressive and significant rise in the probability of death, except for the age group 1-4 years. The age group ≥85 years old (Adjusted OR = 124.256; 95%CI: 97.838-157.807) and males (Adjusted OR = 1.261; 95%CI: 1.243-1.280) were significantly associated with death risk for CAP hospitalization. After 2010, this risk decreased (Adjusted OR = 0.961; 95%CI: 0.940-0.982). The main factors affecting mortality were age, sex, unemployment rate, number of performed procedures and admission quinquennia. Conclusions: Despite a trend of decrease in CAP hospitalizations and associated death since 2012, the numbers of in-hospital mortality showed, in the 15 years under analysis, an overall increase over time, mainly associated with age, in particular very old people (≥ 75 years), males and a higher parish unemployment rate. Therefore, the implementation of CAP preventive measures should be reinforced in these vulnerable groups.

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Section: Discussionsupporting

confidence: 90%

“…Despite many studies carried out, in Europe, it remains difficult to understand discrepancies between countries and geographic regions [4,[12][13][14][15][16]. The analyses of data from one or a few hospitals have the potential of introducing bias.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with in-hospital mortality from community-acquired pneumonia in Portugal: 2000–2014

et al. 2020

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“…A study in Latin America (including Argentina, Paraguay and Uruguay) reported incidence varying between 4.8 and 110/10,000 person-years in people aged 18--64 years and 109-294/10,000 person-years in those over 65 years [11]. Another study in Latin America (Argentina, Brazil, Chile, Colombia, Mexico and Venezuela) reported CAP incidence varying between 32.6 and 80.4/10,000 personyears in a population over 50 years [12].…”

Section: Cap Incidencementioning

confidence: 99%

Burden of Community-Acquired Pneumonia and Unmet Clinical Needs

2020

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Community-acquired pneumonia (CAP) is the leading cause of death among infectious diseases and an important health problem, having considerable implications for healthcare systems worldwide. Despite important advances in prevention through vaccines, new rapid diagnostic tests and antibiotics, CAP management still has significant drawbacks. Mortality remains very high in severely ill patients presenting with respiratory failure or shock but is Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.11673588. J. Ferreira-Coimbra (

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“…Venezuela tuvo una tasa de muerte de 35,1%, Brasil 20,9%, México 16,2%, Argentina 12,9%, Colombia 11,0 % y Chile 10,1%. La mayor parte de las muertes ocurrió en adultos sobre 75 años, representando 69,2% del total de fallecimientos 4 .…”

Section: Introductionunclassified

Duración del tratamiento y administración oral de antimicrobianos en neumonía adquirida en la comunidad

Bernal-Vargas

Cortés

2016

Rev. chil. infectol.

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Community acquired pneumonia (CAP) is an important cause of morbidity and mortality around the world, with high treatment costs due to hospitalization and complications (adverse events due to medications, antibiotic resistance, healthcare associated infections, etc.). It has been proposed administration of short courses and early switch of intravenous administration to oral therapy to avoid costs and complications. There are recommendations about these topics in national and intemational guidelines, based on clinical trials which do not demónstrate diffe-rences in mortality and complications when there is an early change from intravenous administration to the oral route. There are no statistically significant differences in safety and resolution of the disease when short and long treatment schemes were compared. In this review we present the most important guidelines and clinical studies, taking into account the pharmacological differences between different medications. It is considered that early switch from intravenous to oral administration route and use of short cycles in CAP is safe and brings benefits to patients and institutions.

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Morbidity and mortality of pneumonia in adults in six Latin American countries

Abstract: Pneumonia is a common cause of hospitalization and mortality in adults in Latin America. Incidence increases substantially with increasing age, as does the likelihood of hospitalization and mortality.

Cited by 35 publications

References 28 publications

Factors associated with in-hospital mortality from community-acquired pneumonia in Portugal: 2000–2014

Factors associated with in-hospital mortality from community-acquired pneumonia in Portugal: 2000–2014

Burden of Community-Acquired Pneumonia and Unmet Clinical Needs

Duración del tratamiento y administración oral de antimicrobianos en neumonía adquirida en la comunidad

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