Morbidity and Mortality Factors in Twins

Ghai, Vivek; Vidyasagar, Dharmapuri

doi:10.1016/s0095-5108(18)30730-9

Cited by 113 publications

(72 citation statements)

References 43 publications

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“…Table 3. Morbidity among the multiple and the singleton very low birth weight infants (VLBWI) differences in perinatal mortality and major morbidity were observed (11,(13)(14)(15)23). In this study, no significant differences were observed in perinatal mortality and major morbidity between the multiple and the singleton VLBWI.…”

Section: Discussionmentioning

confidence: 58%

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Comparison of Mortality and Morbidity in Multiple versus Singleton Very Low Birth Weight Infants in A Neonatal Intensive Care Unit

et al. 2003

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Multiple births in Korea have been increased recently as a consequence of increased infertility due to advancing maternal age at first birth, and increased use of assisted reproductive technology. Multiples suffer higher mortality and morbidity than singletons. However, it is not clear whether preterm multiple very low birth weight infants (VLBWI) suffer higher mortality and morbidity than comparable singletons. We evaluated 266 singleton and 113 multiple VLBWI to determine whether mortality and morbidity in multiple VLBWI were higher than those in comparable singletons. The rate of in vitro fertilization and cesarean section were significantly higher in multiples than singletons. The total and the adjusted mortality with gestational age and birth weight were not significantly different between the two groups. Maternal age and the incidence of respiratory distress syndrome, patent ductus arteriosus, bronchopulmonary dysplasia, intracranial hemorrhage (grade≥3), cystic periventricular leukomalacia, and retinopathy of prematurity (stage≥3) were not significantly different between the two groups, and the incidence of abnormal brainstem auditory evoked potential was higher among the singletons. These results suggest that multiple VLBWI do not suffer higher mortality or morbidity than comparable singletons.

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Section: Discussionmentioning

confidence: 58%

“…Some authors noted multiple very low birth weight infant (VLBWI) had higher mortality and morbidity than singleton (3)(4)(5)(6)(7)(8)(9)(10), while others found no differences between two groups (11)(12)(13)(14)(15). So, it is not clear whether multiple VLBWI suffer higher mortality and morbidity than comparable singletons.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Mortality and Morbidity in Multiple versus Singleton Very Low Birth Weight Infants in A Neonatal Intensive Care Unit

et al. 2003

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“…Genetic factors can be separated from early environmental influences both in term and preterm infants, not the least because twin pregnancies, more often than singletons, end before term [6,13]. However, the twin approach is also challenging because outcomes are different for same-sex (mono-and dizygous) and sexmixed (dizygous only) twins.…”

Section: Introductionmentioning

confidence: 99%

Impact of sex on perinatal mortality and morbidity in twins

Steen¹,

Källén

Maršál

et al. 2013

Journal of Perinatal Medicine

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Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies -32,090 twins -was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. Conclusion: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin.

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“…Gender and birth order are the other major factors which may also affect the risk of neonatal respiratory illness. Male infants are slightly larger on average and more susceptible to respiratory distress (Ghai & Vidyasagar, 1988), and the second-born twin is at higher risk of intrapartum hypoxia and abnormal delivery (Chen et al, 1993). We found that although the risk of serious respiratory illness is unlikely in the heavier twin, there is an increased risk of RDS over the smaller twin.…”

Section: Discussionmentioning

confidence: 61%

“…The increasing twin rate is partly due to a higher incidence of assisted reproduction and an increase in maternal age at conception (Spellacy et al, 1990). Twins are known to be at increased risk of intrauterine morbidity and of premature delivery (Ghai & Vidyasagar, 1988) therefore multiple pregnancies are usually monitored closely. Several studies have shown that the smaller twin of a pair is at greater risk of intrauterine death, especially as growth discrepancy increases (Chen et al, 1993).…”

mentioning

confidence: 99%