Morbid Changes of the Mandible in Familial Polyposis of the Colon

Shoji, Kenichi; Watanabe, Hikaru; Gotō, Yoshio; Yamada, Naoyuki

doi:10.1620/tjem.126.289

Cited by 7 publications

(3 citation statements)

References 3 publications

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“…The presence of multiple small mandibular osteomas in the great majority of FPC patients has been known during the past decade (1)(2)(3)(4)(5)(6). Clinically evident osteomas often occur years before the first rectal adenomas can be found by proctosigmoidoscopy (12), and the detection of even subclinical osteomas therefore probably predicts the development of FPC.…”

Section: Discussionmentioning

confidence: 99%

Mandibular Osteomas in Unaffected Sibs and Children of Patients with Familial Polyposis Coli

Bülow¹,

Holm²,

Søndergaard³

et al. 1986

Scandinavian Journal of Gastroenterology

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Orthopantomography of the mandible (OTM) showed osteomas in 3 of 34 non-affected sibs and children of the probands in 14 families with polyposis coli. The observed to expected ratio with osteomas was 0.35, which is not significantly lower than 1.0 and in accordance with the frequency in the normal population. Although the result does not enable a definite evaluation of the diagnostic value of OTM, the finding suggests that this method may be used as a supplement to regular proctosigmoidoscopic screening of first-degree relatives of polyposis patients.

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Section: Discussionmentioning

confidence: 99%

Mandibular Osteomas in Unaffected Sibs and Children of Patients with Familial Polyposis Coli

Bülow¹,

Holm²,

Søndergaard³

et al. 1986

Scandinavian Journal of Gastroenterology

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“…It was found that 3 of 5 CFS patients studied had osteomas. Earlier we published studies showing that 76% of FPC patients and 24% of patients with colorectal cancer without known familial predisposition also had osteomas compared to -5% in the normal population (Billow et al, 1984;S0ndergaard et al, 1985). Figure 1 Pedigrees of the two cancer families.…”

mentioning

confidence: 96%

“…Orthopantomography of the mandible (OTM) has shown small mandibular osteomas in 76 to 93% of patients with familial polyposis coli (FPC) (Utsunomiya & Nakamura, 1975;Ushio et al, 1976;Shoji et al, 1978;Bulow et al, 1984). Consequently Gardner's syndrome is considered as a clinical variation of FPC (Billow et al, 1984).…”

mentioning

confidence: 99%

Mandibular osteomas in the Cancer Family Syndrome

Søndergaard¹,

Svendsen²,

Witt³

et al. 1985

Br J Cancer

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Mandibular osteomas in familial polyposis coli

Bülow

Søndergaard

Witt

et al. 1984

Diseases of the Colon &Amp; Rectum

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Orthopantomograms of the mandible were performed on 46 patients with familial polyposis coli having no clinical signs of Gardner's syndrome and on 46 control patients matched according to age and sex. Thirty-five patients (76.1 per cent) and two (4.3 per cent) controls had osteomas (P less than 0.0005). It is concluded that orthopantomography of the mandible is a valuable diagnostic supplement to prophylactic proctosigmoidoscopic examination of first-degree relatives of polyposis patients. Due to the frequent occurrence of mandibular osteomas in polyposis patients without clinically detectable extracolonic manifestations, it is suggested that "Gardner's syndrome" is no longer considered a clinical entity.

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Morbid Changes of the Mandible in Familial Polyposis of the Colon

Cited by 7 publications

References 3 publications

Mandibular Osteomas in Unaffected Sibs and Children of Patients with Familial Polyposis Coli

Mandibular Osteomas in Unaffected Sibs and Children of Patients with Familial Polyposis Coli

Mandibular osteomas in the Cancer Family Syndrome

Mandibular osteomas in familial polyposis coli

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