Moraxella occupied the largest proportion in the nasal microbiome in healthy children, which potential protect them from COVID-19

Xia, Yu; Wang, Li; Zheng, Xuemei; Wen, Yizhou; Zhang, Zhirong; Fan, Li; Zhou, Qin; Yang, Xiao Bing; Xue, Binqian; Lin, Yonghong

doi:10.1016/j.micpath.2022.105685

Cited by 5 publications

(7 citation statements)

References 34 publications

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“…Recent studies demonstrated alterations in the richness and diversity of gut microbiome of SARS-CoV-2 infected patients in follow-up studies [ 9 , 10 ]. Similarly, few studies explored the dynamics of nasal microbiome analysis of the COVID-19 patients [ 6 , [11] , [12] , [13] , [14] ]. The temporal association between healthy, infected and deceased patient's microbiomes is of greater significance in terms of the possible therapeutic interventions that might require additional medical treatments for complete recovery [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Kumar¹,

Pandit²,

Sharma³

et al. 2022

Microbial Pathogenesis

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Section: Introductionmentioning

confidence: 99%

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Kumar¹,

Pandit²,

Sharma³

et al. 2022

Microbial Pathogenesis

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“…Instead, in a pediatric cohort Moraxella was described as a specific signature of the nasal microbiota of CTRLs, suggesting its protective role against COVID-19 in childhood ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring nasopharyngeal microbiota profile in children affected by SARS-CoV-2 infection

Romani,

Del Chierico,

Pane

et al. 2024

Microbiol Spectr

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The relationship between COVID-19 and nasopharyngeal (NP) microbiota has been investigated mainly in the adult population. We explored the NP profile of children affected by COVID-19, compared to healthy controls (CTRLs). NP swabs of children with COVID-19, collected between March and September 2020, were investigated at the admission ( T 0 ), 72 h to 7 days ( T 1 ), and at the discharge ( T 2 ) of the patients. NP microbiota was analyzed by 16S rRNA targeted-metagenomics. Data from sequencing were investigated by QIIME 2.0 and PICRUSt 2. Multiple machine learning (ML) models were exploited to classify patients compared to CTRLs. The NP microbiota of COVID-19 patients ( N = 71) was characterized by reduction of α-diversity compared to CTRLs ( N = 59). The NP microbiota of COVID-19 cohort appeared significantly enriched in Streptococcus , Haemophilus , Staphylococcus , Veillonella , Enterococcus , Neisseria , Moraxella , Enterobacteriaceae, Gemella , Bacillus , and reduced in Faecalibacterium , Akkermansia , Blautia , Bifidobacterium , Ruminococcus , and Bacteroides, compared to CTRLs (FDR < 0.001). Exploiting ML models, Enterococcus, Pseudomonas, Streptococcus, Capnocytopagha, Tepidiphilus, Porphyromonas, Staphylococcus , and Veillonella resulted as NP microbiota biomarkers, in COVID-19 patients. No statistically significant differences were found comparing the NP microbiota profile of COVID-19 patients during the time-points or grouping patients on the basis of high, medium, and low viral load (VL). This evidence provides specific pathobiont signatures of the NP microbiota in pediatric COVID-19 patients, and the reduction of anaerobic protective commensals. Our data suggest that the NP microbiota may have a specific disease-related signature since infection onset without changes during disease progression, regardless of the SARS-CoV-2 VL. IMPORTANCE Since the beginning of pandemic, we know that children are less susceptible to severe COVID-19 disease. A potential role of the nasopharyngeal (NP) microbiota has been hypothesized but to date, most of the studies have been focused on adults. We studied the NP microbiota modifications in children affected by SARS-CoV-2 infection showing a specific NP microbiome profile, mainly composed by pathobionts and almost missing protective anaerobic commensals. Moreover, in our study, specific microbial signatures appear since the first days of infection independently from SARS-CoV-2 viral load.

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“…2 D). Studies have shown that Moraxellale and Psychrobacteriaceae are common on the mucous membranes of animals and humans [ 43 , 44 ]. However, their role in resisting Chlamydia l infection is unknown.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota changes in horses with Chlamydia

Jin,

Li,

et al. 2023

BMC Microbiol

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Background Zoonotic diseases pose a significant threat to public health. Chlamydia, as an intracellular pathogen, can colonize the intestinal tract of humans and animals, changing the gut microbiota. However, only a few studies have evaluated alterations in the gut microbiota of horses infected with Chlamydia. Therefore, this study aimed to investigate gut microbiota and serum biochemical indicators in horses with Chlamydial infection (IG) and healthy horses (HG). Fecal and blood samples were collected from 16 horses (IG: 10; HG: 6) before morning feeding for the determination of gut microbiota and serum biochemical parameters. Results The results showed that total globulin (GLB), alanine aminotransferase (ALT), and creatine kinase (CK) levels were significantly increased in IG compared with HG. Notably, the gut microbial diversity increased in IG compared with HG. Furthermore, Moraxellaceae and Akkermanisa abundance decreased in IG, while Streptococcus, Treponema, Prevotella, and Paraprevotella abundances (13 genera of bacterial species) increased. Compared with HG, carbohydrate metabolism increased in IG while amino acid metabolism decreased. In addition, the abundance of 18 genera of bacteria was associated with the level of five serum biochemical indicators. Conclusions In summary, this study elucidated the influence of Chlamydia infection in horses on the gut microbiota, unraveling consequential alterations in its composition and metabolic profile. Therefore, this study improves the understanding of Chlamydia-induced intestinal infections.

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Moraxella occupied the largest proportion in the nasal microbiome in healthy children, which potential protect them from COVID-19

Cited by 5 publications

References 34 publications

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Exploring nasopharyngeal microbiota profile in children affected by SARS-CoV-2 infection

Gut microbiota changes in horses with Chlamydia

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