We report a case of Moraxella lacunata bacteremia and sepsis associated with ecthyma gangrenosum in a patient with a hematologic malignancy and successful treatment with antimicrobial therapy. Ecthyma gangrenosum, although classically associated with Pseudomonas aeruginosa, can occur with any bacterial, viral, or fungal infection. In this case report, we review the literature on Moraxella lacunata infections and conclude that it should be considered as a viable contender as a cause of ecthyma gangrenosum in any immunocompromised patient who presents with skin lesions and gram-negative rod bacteremia.