Moraxella catarrhalis Lgt2, a galactosyltransferase with broad acceptor substrate specificity

Faglin, Isabelle; Wilson, Jennifer C.; Tiralongo, Joe; Peak, Ian R.

doi:10.1016/j.carres.2010.07.042

Cited by 2 publications

(2 citation statements)

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“…The LOS of M catarrhalis has 3 serotypes, A, B, and C, that are based on the composition and linkage of oligosaccharide chains. Construction of LOS mutants and biochemical analysis of structures contributed new data on the biosynthetic pathways of LOS, which are now characterized for all 3 serotypes 160‐164 . Various mutants were used to show that the oligosaccharide is important in adherence to epithelial cells and in mediating serum resistance 165 .…”

Section: Discussionmentioning

confidence: 99%

“…Construction of LOS mutants and biochemical analysis of structures contributed new data on the biosynthetic pathways of LOS, which are now characterized for all 3 serotypes. [160][161][162][163][164] Various mutants were used to show that the oligosaccharide is important in adherence to epithelial cells and in mediating serum resistance. 165 In addition, human serum antibodies are directed at both core and side chain structures of the LOS molecule.…”

Section: Moraxella Catarrhalismentioning

confidence: 99%

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Panel 5: Microbiology and Immunology Panel

Murphy

Chonmaitree

Barenkamp

et al. 2013

Otolaryngol.--head neck surg.

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Objective The objective is to perform a comprehensive review of the literature from January 2007 through June 2011 on the virology, bacteriology, and immunology related to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Three subpanels with co-chairs comprising experts in the virology, bacteriology, and immunology of otitis media were formed. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a second draft was created. The entire panel met at the 10th International Symposium on Recent Advances in Otitis Media in June 2011 and discussed the review and refined the content further. A final draft was created, circulated, and approved by the panel. Conclusion Excellent progress has been made in the past 4 years in advancing an understanding of the microbiology and immunology of otitis media. Advances include laboratory-based basic studies, cell-based assays, work in animal models, and clinical studies. Implications for Practice The advances of the past 4 years formed the basis of a series of short-term and long-term research goals in an effort to guide the field. Accomplishing these goals will provide opportunities for the development of novel interventions, including new ways to better treat and prevent otitis media.

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Section: Discussionmentioning

confidence: 99%