Mooren's ulcer in China: a study of clinical characteristics and treatment

Chen, Jiaqi; Xie, Hao; Zhen, Wang; Yang, Bing-Shiang; Liu, Zuguo; Chen, Longshan; Gong, X; Yang, Lin

doi:10.1136/bjo.84.11.1244

Cited by 61 publications

(39 citation statements)

References 8 publications

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“…Mooren's ulcer was defined clinically as acute, painful ulceration of the cornea up to, but not involving, the sclera 6 in the absence of evidence of current ocular infection or systemic rheumatological diagnoses or symptoms based on history, review of systems and directed laboratory testing. 32 In patients with peripheral or partial corneal involvement, characteristic findings included deep vessels extending into the ulcer bed from the limbus, and an overhanging, and often opacified, corneal edge ( fig 1A). In some patients, complete peripheral ulceration, leaving only a central island of cornea, had occurred by the time of the first visit ( fig 1B).…”

Section: Institutional Review Board Approval From the Aravind Eyementioning

confidence: 99%

Clinical characteristics of Mooren's ulcer in South India

Srinivasan

Zegans

Zelefsky

et al. 2006

British Journal of Ophthalmology

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Aim: To describe the clinical characteristics at presentation of a large cohort of patients with Mooren's ulcer in South India. Methods: The medical records of patients with Mooren's ulcer examined in the cornea clinic at Aravind Eye Hospital Madurai, Tamil Nadu, India, over a 10-year period were reviewed in this retrospective observational case series. Results: The cohort contained 242 eyes of 166 patients. All patients were from South India, and men outnumbered women by a ratio of 4.7:1. The median and mean ages at presentation were 65 and 61 years, respectively, with a range of 13-95 years. One eye was affected in 90 of 166 (54%) patients. Visual acuity in the affected eye at presentation ranged from 6/6 to light perception, and was 6/12 or better in 34 of 242 (14%) eyes, between 6/12 and 3/60 in 168 (69%) eyes, and worse than 3/60 in 40 (17%) eyes. Partial peripheral corneal ulceration was observed in 222 (92%) eyes, complete peripheral corneal ulceration was observed in 15 (6%) eyes and total corneal ulceration was observed in 5 (2%) eyes. For those 222 eyes with partial peripheral ulceration, 152 (68%) showed temporal involvement, 129 (58%) showed nasal involvement, 116 (52%) showed inferior involvement and 30 (14%) showed superior involvement. Perforation was observed in 26 (11%) eyes, and was more common in eyes with peripheral as compared with total ulceration (p,0.001). Identified risk factors in the cohort included evidence of prior corneal surgery (22%), corneal trauma (17%) and corneal infection (2%). Conclusions: Mooren's ulcer is a rare and potentially blinding eye condition observed not infrequently in the cornea clinic at Aravind Eye Hospital. Men are affected more often than women and may present with either unilateral or bilateral disease. Perforation is observed in approximately 1 in 10 affected eyes at presentation and occurs most often in the setting of peripheral ulceration. The occurrence of prior corneal surgery, trauma or infection in nearly one third of patients supports theories of exposure to corneal antigen in the pathogenesis of this disorder.

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Section: Institutional Review Board Approval From the Aravind Eyementioning

confidence: 99%

Clinical characteristics of Mooren's ulcer in South India

Srinivasan

Zegans

Zelefsky

et al. 2006

British Journal of Ophthalmology

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“…Mooren's ulcer is a rare disease; a study approximated the incidence to be 0.03% in China [2] . In our tertiary health center, we came across only 4 cases of bilateral atypical Mooren's ulcer in last 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Medical treatment of Mooren's ulcer consists of oral and topical corticosteroid, cyclosporine eye drops [2,1] and autologous serum [20,21] . If medical treatment does not control the inflammation, conjunctival resection can be performed.…”

Section: Discussionmentioning

confidence: 99%

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Atypical Mooren’s Ulcer: Our experience

Bamotra¹

2017

JMSCR

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“…1 Our previous work described the clinical characteristics of patients with Mooren's corneal ulcer in China and demonstrated the effectiveness of treatment with lamellar keratoplasty plus 1% cyclosporine A eye drops. 2 The etiology of Mooren's ulcer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis C virus infection is not associated with Mooren's ulcer

Yuan

et al. 2007

Eye

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Aim To investigate the association between chronic hepatitis C virus (HCV) infection and Mooren's ulcer. Methods Eight patients from different parts of China who were diagnosed with Mooren's ulcer at the Zhongshan Ophthalmic Center, Guangzhou (China) were screened for chronic HCV infection. Mooren's ulcer was diagnosed by the typical ulcer morphology, detailed case history, physical examination, and comprehensive laboratory tests. All patients had serological screening for HCV infection. Results Six male and two female patients were enrolled in the study. Their ages ranged from 31 to 65 years (mean 43.6713.7). None of them was reported to have any clinical evidence of chronic HCV infection before enrolment and all were negative for HCV serology. Conclusion There was no association between chronic HCV infection and Mooren's ulcer in this limited case series study.

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Mooren's ulcer in China: a study of clinical characteristics and treatment

Abstract: Aims-To

Cited by 61 publications

References 8 publications

Clinical characteristics of Mooren's ulcer in South India

Clinical characteristics of Mooren's ulcer in South India

Atypical Mooren’s Ulcer: Our experience

Chronic hepatitis C virus infection is not associated with Mooren's ulcer

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