Moonlighting proteins: beacon of hope in era of drug resistance in bacteria

Yadav, Pramod; Singh, Rashmi; Sur, Souvik; Bansal, Sandhya; Chaudhry, Uma; Tandon, Vibha

doi:10.1080/1040841x.2022.2036695

Cited by 5 publications

(8 citation statements)

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“…For practical purposes, not all MLPs are described in this article. Therefore, for more information, Table 3 presents the databases that track the increasing number of MLPs discovered [ 44 ].…”

Section: Moonlighting Proteinsmentioning

confidence: 99%

“…Second, it has been hypothesized that gene duplication promotes the development of the MLP function. Third, MLPs increase mutational robustness by enabling biological systems to traverse new landscapes not predicted in natural selection [ 43 , 44 ].…”

Section: Moonlighting Proteinsmentioning

confidence: 99%

“…MLPs conserve energy, which is a limited resource in any system, by delegating two functions to a single protein. In addition, the two functions are typically related [ 44 ].…”

Section: Moonlighting Proteinsmentioning

confidence: 99%

“…The general structure and physical properties of proteins are appropriate to allow them to carry out their primary function and bind to a substrate and catalyze a reaction. During the evolution of proteins over the years, no significant changes in their structure were required to allow the protein to adapt to perform different functions [ 44 ]. However, it has been found that some MLPs change their function by undergoing large conformational changes or transitions between intrinsically unfolded domains and multiple folded structures, so that different conformations of the protein structure can perform different functions.…”

Section: Moonlighting Proteinsmentioning

confidence: 99%

“…Hundreds of MLPs have been discovered in several prokaryotes and eukaryotes; prokaryotes are involved in virulence, whereas eukaryotes are involved in pathogen virulence and attachment. Bacterial MLPs have also been observed as homologs to human proteins, such as chaperonins, aldolases, GAPDH, and enolases [ 43 , 44 ]. In 1996, Wool [ 50 ] proposed the hypothesis that many RPs have a second function in addition to their main role.…”

Section: Moonlighting Proteinsmentioning

confidence: 99%

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Ribosomes: The New Role of Ribosomal Proteins as Natural Antimicrobials

Hurtado-Rios

Carrasco-Navarro

Almanza-Perez

et al. 2022

IJMS

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Moonlighting proteins are those capable of performing more than one biochemical or biophysical function within the same polypeptide chain. They have been a recent focus of research due to their potential applications in the health, pharmacological, and nutritional sciences. Among them, some ribosomal proteins involved in assembly and protein translation have also shown other functionalities, including inhibiting infectious bacteria, viruses, parasites, fungi, and tumor cells. Therefore, they may be considered antimicrobial peptides (AMPs). However, information regarding the mechanism of action of ribosomal proteins as AMPs is not yet fully understood. Researchers have suggested that the antimicrobial activity of ribosomal proteins may be associated with an increase in intracellular reactive oxidative species (ROS) in target cells, which, in turn, could affect membrane integrity and cause their inactivation and death. Moreover, the global overuse of antibiotics has resulted in an increase in pathogenic bacteria resistant to common antibiotics. Therefore, AMPs such as ribosomal proteins may have potential applications in the pharmaceutical and food industries in the place of antibiotics. This article provides an overview of the potential roles of ribosomes and AMP ribosomal proteins in conjunction with their potential applications.

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Section: Moonlighting Proteinsmentioning

confidence: 99%

Section: Moonlighting Proteinsmentioning

confidence: 99%

“…MLPs conserve energy, which is a limited resource in any system, by delegating two functions to a single protein. In addition, the two functions are typically related [ 44 ].…”

Section: Moonlighting Proteinsmentioning

confidence: 99%

Section: Moonlighting Proteinsmentioning

confidence: 99%